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Ovarian reserve and autoimmune thyroid diseases

https://doi.org/10.14341/omet10037

Abstract

Present literature review provides information about clinical trials that evaluated the association of the carriage of antithyroid antibodies (ATA) and the reduction of the ovarian reserve, as well as the effectiveness of assisted reproductive technologies. The ambiguity and sometimes the opposite of the conclusions of different authors, makes it possible to recommend a balanced attitude to the advisability of screening for ATA in women with a reproductive dysfunction as well as the therapeutic measures proposed in some guidelines based on the results of such examination.

About the Authors

Olga R. Grigoryan
https://www.endocrincentr.ru/doctors/grigoryan-olga-rafaelevna

Endocrinology Research Centre


Russian Federation

MD, Professor


 



Natal'ya S. Krasnovskaya

City polyclinic №9 of the Moscow Health Department


Russian Federation

MD, Department of Endocrinology



Robert K. Mikheev

A.I. Yevdokimov Moscow State University of Medicine and Dentistry


Russian Federation

medical student


 



Irina S. Yarovaya
https://www.endocrincentr.ru/doctors/yarovaya-irina-sergeevna

Endocrinology Research Centre


Russian Federation

MD, PhD



Elena N. Andreeva
https://www.endocrincentr.ru/doctors/andreeva-elena-nikolaevna

Endocrinology Research Centre


Russian Federation

MD, Professor


 


 



Ivan I. Dedov
https://www.endocrincentr.ru/rukovodstvo/dedov-ivan-ivanovich

Endocrinology Research Centre


Russian Federation

MD, PhD, professor



References

1. Poppe K, Velkeniers B. Female infertility and the thyroid. Best Pract Res Clin Endocrinol Metab. 2004;18(2):153-165. doi: 10.1016/j.beem.2004.03.004

2. Mintziori G, Anagnostis P, Toulis KA, Goulis DG. Thyroid diseases and female reproduction. Minerva Med. 2012;103(1):47-62. PMID: 22278068

3. Reh A, Grifo J, Danoff A. What is a normal thyroid-stimulating hormone (TSH) level? Effects of stricter TSH thresholds on pregnancy outcomes after in vitro fertilization. Fertil Steril. 2010;94(7):2920-2922. doi: 10.1016/j.fertnstert.2010.06.041

4. Murto T, Bjuresten K, Landgren B-M, Stavreus-Evers A. Predictive value of hormonal parameters for live birth in women with unexplained infertility and male infertility. Reprod Biol Endocrinol. 2013;11(1):61. doi: 10.1186/1477-7827-11-61

5. Krassas GE, Perros P, Kaprara A. Thyroid autoimmunity, infertility and miscarriage. Expert Rev Endocrinol Metab. 2008;3(2):127-136. doi: 10.1586/17446651.3.2.127

6. Geva E, Lessing JB, Lerner-Geva L, et al. The Presence of Antithyroid Antibodies in Euthyroid Patients With Unexplained Infertility and Tubal Obstruction. Am J Reprod Immunol. 1997;37(2):184-186. doi: 10.1111/j.1600-0897.1997.tb00210.x

7. Janssen O, Mehlmauer N, Hahn S, et al. High prevalence of autoimmune thyroiditis in patients with polycystic ovary syndrome. Eur J Endocrinol. 2004;37(2):363-369. doi: 10.1530/eje.0.1500363

8. Боярский К.Ю., Гайдуков С.Н., Чинчаладзе А.С. Факторы, определяющие овариальный резерв женщины // Журнал акушерства и женских болезней. – 2009. – Т.58. – №2. – С.65-71. [Boyarsky CY, Gaidukov SN, Chinchaladze AS. Factors which can predict ovarian reserve. Journal of obstetrics and women's diseases. 2009;58(2):65-71. (In Russ.)]

9. Jamil Z, Fatima SS, Ahmed K, Malik R. Anti-Mullerian Hormone: Above and Beyond Conventional Ovarian Reserve Markers. Dis Markers. 2016;2016(2):1-9. doi: 10.1155/2016/5246217

10. Wilson C, Elstein M, Eade O., Lloyd R, Wright R. SMOOTH-MUSCLE ANTIBODIES IN INFERTILITY. Lancet. 1975;306(7947):1238-1239. doi: 10.1016/S0140-6736(75)92074-7

11. Roussev RG, Kaider BD, Price DE, Coulam CB. Laboratory Evaluation of Women Experiencing Reproductive Failure. Am J Reprod Immunol. 1996;35(4):415-420. doi: 10.1111/j.1600-0897.1996.tb00503.x

12. Geva E, Lessing JB, Lerner-Geva L, et al. The Presence of Antithyroid Antibodies in Euthyroid Patients With Unexplained Infertility and Tubal Obstruction. Am J Reprod Immunol. 1997;37(2):184-186. doi: 10.1111/j.1600-0897.1997.tb00210.x

13. Kutteh W. Increased prevalence of antithyroid antibodies identified in women with recurrent pregnancy loss but not in women undergoing assisted reproduction. Fertil Steril. 1999;71(5):843-848. doi: 10.1016/S0015-0282(99)00091-6

14. Reimand K, Talja I, Metsküla K, et al. Autoantibody studies of female patients with reproductive failure. J Reprod Immunol. 2001;51(2):167-176. doi: 10.1016/S0165-0378(01)00075-4

15. Poppe K, Glinoer D, Van Steirteghem A, et al. Thyroid Dysfunction and Autoimmunity in Infertile Women. Thyroid. 2002;12(11):997-1001. doi: 10.1089/105072502320908330

16. Abalovich M, Mitelberg L, Allami C, et al. Subclinical hypothyroidism and thyroid autoimmunity in women with infertility. Gynecol Endocrinol. 2007;23(5):279-283. doi: 10.1080/09513590701259542

17. Kachuei M, Jafari F, Kachuei A, Keshteli AH. Prevalence of autoimmune thyroiditis in patients with polycystic ovary syndrome. Arch Gynecol Obstet. 2012;285(3):853-856. doi: 10.1007/s00404-011-2040-5

18. Grassi G, Balsamo A, Ansaldi C, et al. Thyroid autoimmunity and infertility. Gynecol Endocrinol. 2001;15(5):389-396. doi: 10.1080/713602919

19. Muller A, Verhoeff A, Mantel M, Berghout A. Thyroid autoimmunity and abortion: a prospective study in women undergoing in vitro fertilization. Fertil Steril. 1999;71(1):30-34. doi: 10.1016/S0015-0282(98)00394-X

20. Kilic S, Tasdemir N, Yilmaz N, et al. The effect of anti-thyroid antibodies on endometrial volume, embryo grade and IVF outcome. Gynecol Endocrinol. 2008;24(11):649-655. doi: 10.1080/09513590802531112

21. Гурьева В.А., Куракина В.А. Оценка факторов, определяющих овариальный резерв у женщин с нарушенной репродуктивной функцией // Журнал акушерства и женских болезней. – 2012. – Т.61. – №6. – С.76-81. [Gur'eva VA, Kurakina VA. Evaluation factors, determining ovarian reserve in women with reproductive function disorders. Journal of obstetrics and women's diseases. 2012;61(6):76-81. (In Russ.)]

22. Pirgon O, Sivrice C, Demirtas H, Dundar B. Assessment of ovarian reserve in euthyroid adolescents with Hashimoto thyroiditis. Gynecol Endocrinol. 2016;32(4):306-310. doi: 10.3109/09513590.2015.1116510

23. Tuten A, Hatipoglu E, Oncul M, et al. Evaluation of ovarian reserve in Hashimoto’s thyroiditis. Gynecol Endocrinol. 2014;30(10):708-711. doi: 10.3109/09513590.2014.926324

24. Magri F, Schena L, Capelli V, et al. Anti-Mullerian hormone as a predictor of ovarian reserve in ART protocols: the hidden role of thyroid autoimmunity. Reprod Biol Endocrinol. 2015;13(1):106. doi: 10.1186/s12958-015-0103-3

25. Polyzos NP, Sakkas E, Vaiarelli A, et al. Thyroid autoimmunity, hypothyroidism and ovarian reserve: a cross-sectional study of 5000 women based on age-specific AMH values. Hum Reprod. 2015;30(7):1690-1696. doi: 10.1093/humrep/dev089

26. Saglam F, Onal ED, Ersoy R, et al. Anti-Müllerian hormone as a marker of premature ovarian aging in autoimmune thyroid disease. Gynecol Endocrinol. 2015;31(2):165-168. doi: 10.3109/09513590.2014.973391

27. Ayesha, Jha V, Goswami D. Premature Ovarian Failure: An Association with Autoimmune Diseases. J Clin Diagn Res. 2016;10(10):10-12. doi: 10.7860/JCDR/2016/22027.8671

28. Weghofer A, Barad DH, Darmon S, et al. What affects functional ovarian reserve, thyroid function or thyroid autoimmunity? Reprod Biol Endocrinol. 2016;14(1):26. doi: 10.1186/s12958-016-0162-0

29. Poppe K, Glinoer D, Tournaye H, et al. Impact of Ovarian Hyperstimulation on Thyroid Function in Women with and without Thyroid Autoimmunity. J Clin Endocrinol Metab. 2004;89(8):3808-3812. doi: 10.1210/jc.2004-0105

30. Lazzarin N, Moretti C, De Felice G, et al. Further Evidence on the Role of Thyroid Autoimmunity in Women with Recurrent Miscarriage. Int J Endocrinol. 2012;2012(8):1-4. doi: 10.1155/2012/717185

31. Monteleone P, Parrini D, Faviana P, et al. Female Infertility Related to Thyroid Autoimmunity: The Ovarian Follicle Hypothesis. Am J Reprod Immunol. 2011;66(2):108-114. doi: 10.1111/j.1600-0897.2010.00961.x

32. Kelkar RL, Meherji PK, Kadam SS, et al. Circulating auto-antibodies against the zona pellucida and thyroid microsomal antigen in women with premature ovarian failure. J Reprod Immunol. 2005;66(1):53-67. doi: 10.1016/j.jri.2005.02.003


Supplementary files

Review

For citations:


Grigoryan O.R., Krasnovskaya N.S., Mikheev R.K., Yarovaya I.S., Andreeva E.N., Dedov I.I. Ovarian reserve and autoimmune thyroid diseases. Obesity and metabolism. 2019;16(2):16-21. (In Russ.) https://doi.org/10.14341/omet10037

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ISSN 2071-8713 (Print)
ISSN 2306-5524 (Online)