Associations of sex hormones with components of insulin-glucose homeostasis
Abstract
In this literature review, an attempt is made to analyze the interrelationships of the main sex hormones with the processes of development and progression of insulin resistance as a fundamental pathogenetic component of insulin-glucose homeostasis. In the evaluation of sex steroids, a complex approach was used - the associations of both androgens and estrogens in males and females are described in detail, a great deal of attention is paid to the violation of the secretion and effectiveness of the main adipocytokines - leptin and adiponectin in the sex hormone-insulin-glucose interaction chain. At the end of the review, new data on the expression of sodium-dependent glucose cotransporter (SGLT) and glucose transporters (GLUT) in animals, depending on sex, are presented.
About the Authors
Oksana V. TsygankovaNovosibirsk State Medical University; Research Institute of therapy and preventive medicine" branch of Federal Research Institute of a Cytology and Genetics
Russian Federation
ScD, associate professor
Artur R. Badin
Novosibirsk State Medical University
Russian Federation
resident
Zoya G. Bondareva
Novosibirsk State Medical University
Russian Federation
ScD, professor
Natalya G. Lozhkina
Novosibirsk State Medical University
Russian Federation
ScD, associate professor
Dmitrii Y. Platonov
Tver State Medical University
Russian Federation
ScD, professor
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Tsygankova O.V., Badin A.R., Bondareva Z.G., Lozhkina N.G., Platonov D.Y. Associations of sex hormones with components of insulin-glucose homeostasis. Obesity and metabolism. 2018;15(2):3-10. (In Russ.)
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