The evaluation of chromosome telomere length change as a criterion of life expectancy in bariatric practice
Farida K. Bekmurzinova,
Oral B. Ospanov,
Ainur R. Akilzhanova,
Ulan A. Kozhamkulov,
Saule E. Rakhimova 
Abstract
In recent decades, the prevalence of obesity has been steadily increasing in most countries of the world. Overweight is a risk factor for a wide range of endocrine, cardiovascular, gastrointestinal, metabolic, neoplastic and musculoskeletal disorders and diseases. As you know, obesity is a state of chronic inflammation and severe oxidative stress, which will certainly affect the length of the chromosome telomeres. The dynamics of telomere length changes plays a decisive role in the regulation of cellular processes and cellular changes. Damage to telomeres, chromatin structures that help maintain the stability of the genome, leads to cell death or aging. However, information on how telomere length changes after weight loss through bariatric surgery remains limited to date. There are several types of bariatric surgery, each of which has its advantages and disadvantages. Based on this, it is possible that the restoration of the telomere length will differ depending on the technique used. This review describes the mechanisms for shortening leukocyte telomeres, and how bariatric surgery can affect this. The review also includes an analysis of evidence linking obesity and accelerated aging processes, as they are regulated by telomeres.
About the Authors
Farida K. Bekmurzinova
Omsk State Medical University
Russian Federation
Russian Federation
resident
Oral B. Ospanov
Astana Medical University; Laboratory of Genomic and Personalized Medicine «National Laboratory Astana» Nazarbayev University
Kazakhstan
Kazakhstan
MD, PhD, Professor, Head of the Department of Laparoscopic and Bariatric Surgery
Ainur R. Akilzhanova
Laboratory of Genomic and Personalized Medicine «National Laboratory Astana» Nazarbayev University
Kazakhstan
Kazakhstan
MD, PhD, Professor
Ulan A. Kozhamkulov
Laboratory of Genomic and Personalized Medicine «National Laboratory Astana» Nazarbayev University
Kazakhstan
Kazakhstan
PhD, Leading Research Scientist Laboratory of Genomic and Personalized Medicine
Saule E. Rakhimova
Laboratory of Genomic and Personalized Medicine «National Laboratory Astana» Nazarbayev University
Kazakhstan
Kazakhstan
MD, C.B.Sc., Leading researcher Laboratory of Genomic and Personalized Medicine
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For citations:
Bekmurzinova F.K., Ospanov O.B., Akilzhanova A.R., Kozhamkulov U.A., Rakhimova S.E. The evaluation of chromosome telomere length change as a criterion of life expectancy in bariatric practice. Obesity and metabolism. 2020;17(2):125-129. (In Russ.)
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