T/A polymorphism of the FTO gene and lifestyle are associated with fat accumulation in different age groups of men
https://doi.org/10.14341/omet9798
Abstract
BACKGROUND: Adiposity development and its complications are determined by lifestyle, genetic mechanisms and their interactions. Among the obesity-related genes, polymorphisms in the fat mass and obesity associated (FTO) gene are strongly associated with body fat estimates in different populations.
AIMS: to examine the association between the FTO polymorphism (T/A, rs9939609) and fat accumulation in adult russian males.
MATERIALS AND METHODS: The study engaged 205 participants; the age ranged from 17 to 52 years. Samples of buccal smears were collected and genomic DNA was isolated for T/A polymorphism genotyping. Anthropometric measurements were conducted with caliperometry and body composition was estimated by bioimpedance analysis.
RESULTS: Genotype frequencies in the whole studied sample were as follows FTO*TT 14%, FTO*AT 52,6%, FTO*AA 33,4% (χ2HW = 1,65 p=0,193). The minor A allele was significantly associated with increased fat accumulation and abdominal adiposity.
CONCLUSIONS: Among different lifestyle modifications regular and consistent programmes of exercise are most efficient strategy to reduce abdominal fat deposits significantly, independent of FTO genotype.
Supporting agencies: Russian found of Fundamental Research 17-26-03004-OGN and 18-59-94015 MOKNM_a
About the Authors
Elvira A. BondarevaLomonosov Moscow State University
Russian Federation
PhD (Biology), Seniour scientific researcher
Ludmila V. Zadorozhnaya
Lomonosov Moscow State University
Russian Federation
PhD (Biology), Leading scientific reasearcher
Irina A. Khomyakova
Lomonosov Moscow State University
Russian Federation
PhD (Biology), Leading scientific reasearcher
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For citations:
Bondareva E.A., Zadorozhnaya L.V., Khomyakova I.A. T/A polymorphism of the FTO gene and lifestyle are associated with fat accumulation in different age groups of men. Obesity and metabolism. 2019;16(2):49-53. (In Russ.) https://doi.org/10.14341/omet9798
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