Challenges in differential diagnosis between primary and secondary forms of hyperparathyroidism
https://doi.org/10.14341/omet2017348-53
Abstract
Hyperparathyroidism is a disease characterized by excessive secretion of parathyroid hormone (PTH) in the chief cells of parathyroid glands. There are three types of hyperparathyroidism: primary, secondary, and tertiary depending on the cause of this disease. By the secondary hyperparathyroidism calcium-sensing receptors (CaSR) and vitamin D receptors (VDR) lead to disturbance of phosphorus-calcium exchange and to development of a parathyroid glands hyperplasia. Treatment of secondary hyperparathyroidism with vitamin D showed the efficiency not only in normalization of clinical laboratory indicators but also in involution of changes in parathyroid glands. We represent the clinical case of a patient with secondary hyperparathyroidism caused by hypovitaminosis D, parathyroid hyperplasia more than 1 cm. The long-term oral therapy with active vitamin D led to the positive dynamics of PTH levels, as well as complete reduction of parathyroid lesion.
About the Authors
Natalia G. MokryshevaEndocrinology Research Centre
Russian Federation
Sc.D.
Anna K. Eremkina
Endocrinology Research Centre
Russian Federation
PhD
Svetlana S. Mirnaya
Endocrinology Research Centre
Russian Federation
postgraduate student
Elena V. Kovaleva
Endocrinology Research Centre
Russian Federation
postgraduate student
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1. Рис. 1. Развитие диффузной и узелковой гиперплазии ОЩЖ (по материалам [12]) | |
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For citations:
Mokrysheva N.G., Eremkina A.K., Mirnaya S.S., Kovaleva E.V. Challenges in differential diagnosis between primary and secondary forms of hyperparathyroidism. Obesity and metabolism. 2017;14(3):48-53. (In Russ.) https://doi.org/10.14341/omet2017348-53
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