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Challenges in differential diagnosis between primary and secondary forms of hyperparathyroidism

https://doi.org/10.14341/omet2017348-53

Abstract

Hyperparathyroidism is a disease characterized by excessive secretion of parathyroid hormone (PTH) in the chief cells of parathyroid glands. There are three types of hyperparathyroidism: primary, secondary, and tertiary depending on the cause of this disease. By the secondary hyperparathyroidism calcium-sensing receptors (CaSR) and vitamin D receptors (VDR) lead to disturbance of phosphorus-calcium exchange and to development of a parathyroid glands hyperplasia. Treatment of secondary hyperparathyroidism with vitamin D showed the efficiency not only in normalization of clinical laboratory indicators but also in involution of changes in parathyroid glands. We represent the clinical case of a patient with secondary hyperparathyroidism caused by hypovitaminosis D, parathyroid hyperplasia more than 1 cm. The long-term oral therapy with active vitamin D led to the positive dynamics of PTH levels, as well as complete reduction of parathyroid lesion.

About the Authors

Natalia G. Mokrysheva

Endocrinology Research Centre


Russian Federation

Sc.D.



Anna K. Eremkina

Endocrinology Research Centre


Russian Federation

PhD



Svetlana S. Mirnaya

Endocrinology Research Centre


Russian Federation

postgraduate student



Elena V. Kovaleva

Endocrinology Research Centre


Russian Federation

postgraduate student



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Supplementary files

1. Рис. 1. Развитие диффузной и узелковой гиперплазии ОЩЖ (по материалам [12])
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Type Исследовательские инструменты
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For citations:


Mokrysheva N.G., Eremkina A.K., Mirnaya S.S., Kovaleva E.V. Challenges in differential diagnosis between primary and secondary forms of hyperparathyroidism. Obesity and metabolism. 2017;14(3):48-53. (In Russ.) https://doi.org/10.14341/omet2017348-53

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