Mekhanizmy narusheniya obmena glyukozy u litss «prediabetom»
https://doi.org/10.14341/2071-8713-4874
Abstract
We have performed an estimation of metabolic disorders in 70 persons with various early glucose metabolism abnormalities
(IFG and IGT). Oral glucose tolerance test (ОGTT) and intravenous glucose tolerance test (IVGTT) were done in all subjects. HbA1с,
insulin and C-peptide levels were also determined. Further НОМА-R, QUICKI, MATSUDA indexes, speed of glucose elimination from
the blood (k), production of glucose (H) and a degree of glucose metabolism disorders (pN) were estimated. Glucose hyperproduction
and liver insulin resistance is more typical for IFG, than for isolated IGT. It was confirmed by higher parameter of liver glucose production
(H) and HOMA-R index in patients with IFG. On the contrary peripheral insulin resistance is more typical for isolated IGT. Index of insulin
sensitivity MATSUDA and speed of glucose elimination from the blood (k) were lower in IGT than in IFG patients. First phase
of insulin secretion was broken in patients with combination IGT and IFG, which can explain the high incidence of transformation in
2 type diabetes mellitus in patients with combination IGT and IFG. The lowest HbA1c levels was found among persons with IGT. It is
likely that ordinary life food intake (not glucose loading) in this group of patients does not result in chronic hyperglycemia and excessive
hemoglobin glycation.
(IFG and IGT). Oral glucose tolerance test (ОGTT) and intravenous glucose tolerance test (IVGTT) were done in all subjects. HbA1с,
insulin and C-peptide levels were also determined. Further НОМА-R, QUICKI, MATSUDA indexes, speed of glucose elimination from
the blood (k), production of glucose (H) and a degree of glucose metabolism disorders (pN) were estimated. Glucose hyperproduction
and liver insulin resistance is more typical for IFG, than for isolated IGT. It was confirmed by higher parameter of liver glucose production
(H) and HOMA-R index in patients with IFG. On the contrary peripheral insulin resistance is more typical for isolated IGT. Index of insulin
sensitivity MATSUDA and speed of glucose elimination from the blood (k) were lower in IGT than in IFG patients. First phase
of insulin secretion was broken in patients with combination IGT and IFG, which can explain the high incidence of transformation in
2 type diabetes mellitus in patients with combination IGT and IFG. The lowest HbA1c levels was found among persons with IGT. It is
likely that ordinary life food intake (not glucose loading) in this group of patients does not result in chronic hyperglycemia and excessive
hemoglobin glycation.
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, , , Mekhanizmy narusheniya obmena glyukozy u litss «prediabetom». Obesity and metabolism. 2009;6(4):23-27. (In Russ.) https://doi.org/10.14341/2071-8713-4874
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