Витамин К-зависимые белки: остеокальцин, матриксный Gla-белок и их внекостные эффекты

Витамин К - это жирорастворимый витамин, который играет значимую роль в обмене веществ в костях и в соединительной ткани, поддержании свертывающих свойств крови. Витамин K участвует в карбоксилировании остатков глутаминовой кислоты в полипептидных цепях 14 человеческих белков, что обеспечивает их необходимыми функциональными свойствами. Недостаточное витамин К-зависимое карбоксилирование данных белков, приводит к изменению их биологической активности. В данном обзоре литературы широко освещаются механизмы витамин К-зависимого карбоксилирования, механизм костного и внекостного действия различных по степени карбоксилирования форм остеокальцина и матриксного Gla-белка.

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