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Associations of adupocutokine and metaboliv hormone level in young people aged 25-44 years with type 2 diabetes mellitus and abdominal obesity

https://doi.org/10.14341/omet12974

Abstract

BACKGROUND: Diabetes mellitus and obesity are two closely related diseases that are a global public health problem. Obesity is characterized by an increase in the volume of adipose tissue and a change in the production and function of adipocytokines, which leads to a violation of the regulation of insulin sensitivity and glucose metabolism, contributing to the development of insulin resistance and diabetic pathology.

AIM: The aim of this study was to evaluate the concentrations of individual adipocytokines and metabolic hormones in patients with DM2 and without diabetes, depending on the presence/absence of abdominal obesity (AO).

MATERIALS AND METHODS: A single-center observational cross-sectional study was conducted. A population subsample of men and women aged 25–44 years was examined. Socio-demographic data were collected, anthropometric measurements were performed. The levels of amylin, C-peptide, ghrelin, glucose-dependent insulinotropic polypeptide, glucagon-like peptide 1 (GLP-1), glucagon, were determined in blood serum by multiplex analysis using a set of reagents Human Metabolic Hormone V3 (USA) and Human Adipokine Panel 1 (USA) on a Luminex MAGPIX flow fluorimeter (USA). interleukin 6, insulin, leptin, monocytic chemotactic factor 1 (MCP-1), pancreatic polypeptide (PP), peptide YY (PYY), tumor necrosis factor alpha (TNF-α), adiponectin, adipsin, lipocalin-2, plasminogen activator inhibitor-1 (PAI-1) and resistin.

RESULTS: The study included 105 people. The main group consisted of 35 people with diabetes mellitus, 11 of them without AO and 24 with AO, the control group consisted of 70 people without diabetes mellitus (35 people with AO and 35 without AO), comparable in gender and age with the main group. In individuals with abdominal obesity, regardless of the presence of type 2 diabetes mellitus, the levels of C-peptide, GLP-1, insulin, leptin and TNF-alpha are higher than in individuals without abdominal obesity. The chance of having diabetes mellitus and AO is associated with an increase in leptin levels (OR=1.367, 95% CI: 1.050–1.779, p=0.020).

CONCLUSION: The results of our study show that the indicators of the adipocytokine profile differ significantly in individuals with the presence/absence of abdominal obesity. According to our data, leptin makes the greatest contribution to the development of SD2 against the background of AO. Further research is needed to identify causal relationships and determine whether treatment that regulates adipocytokine levels can help in personalized approaches to the prevention and treatment of type 2 diabetes mellitus.

About the Authors

E. V. Kashtanova
Research Institute of Internal and Preventive Medicine
Russian Federation

Elena V. Kashtanova - MD, PhD in biology.

Novosibirsk

Researcher ID: J-4675-2016; Scopus Author ID: 8645249000


Competing Interests:

None



Ya. V. Polonskaya
Research Institute of Internal and Preventive Medicine
Russian Federation

Yana V. Polonskaya - MD, PhD in biology.

Novosibirsk

Researcher ID: H-4397-2016; Scopus Author ID: 57216801775


Competing Interests:

None



L. V. Shcherbakova
Research Institute of Internal and Preventive Medicine
Russian Federation

Liliya V. Shcherbakova.

Novosibirsk

Researcher ID: ABA-9069-2021; Scopus Author ID: 15030341800


Competing Interests:

None



E. M. Stakhneva
Research Institute of Internal and Preventive Medicine
Russian Federation

Ekaterina M. Stakhneva - PhD in biology.

Novosibirsk

Researcher ID: R-1589-2016; Scopus Author ID: 24774022600


Competing Interests:

None



V. S. Shramko
Research Institute of Internal and Preventive Medicine
Russian Federation

Viktoriya S. Shramko - MD, PhD.

Novosibirsk

Researcher ID: ABG-9543-2020; Scopus Author ID: 57194556107


Competing Interests:

None



S. V. Mustafina
Research Institute of Internal and Preventive Medicine
Russian Federation

Svetlana V. Mustafina - MD, PhD.

Novosibirsk


Competing Interests:

None



A. D. Khudyakova
Research Institute of Internal and Preventive Medicine
Russian Federation

Alena D. Khudiakova - MD, PhD.

Novosibirsk

Researcher ID: AAC-7782-2019; Scopus Author ID: 57221943610


Competing Interests:

None



Yu. I. Ragino
Research Institute of Internal and Preventive Medicine
Russian Federation

Yulia I. Ragino - MD, PhD, Professor.

Novosibirsk

Researcher ID: E-9498-2015; Scopus Author ID: 6602418274


Competing Interests:

None



References

1. Qadir MI, Ahmed Z. lep Expression and Its Role in Obesity and Type-2 Diabetes. Crit Rev Eukaryot Gene Expr. 2017;27(1):47-51. doi: https://doi.org/10.1615/CritRevEukaryotGeneExpr.2017019386

2. Urbanavitius V, Abaliksta T, Brimas G, et al. Comparison of changes in blood glucose, insulin resistance indices, and adipokine levels in diabetic and nondiabetic subjects with morbid obesity after laparoscopic adjustable gastric banding. Medicina (Kaunas) 2013;49(1):9-14

3. Etemad A, Ramachandran V, Pishva SR, et al. Analysis of Gln223Agr polymorphism of Leptin Receptor Gene in type II diabetic mellitus subjects among Malaysians. Int J Mol Sci. 2013;14(9):19230-44. doi: https://doi.org/10.3390/ijms140919230

4. Isfort M, Stevens SC, Schaffer S, Jong CJ, Wold LE. Metabolic dysfunction in diabetic cardiomyopathy. Heart Fail Rev. 2014;19(1):35-48. doi: https://doi.org/10.1007/s10741-013-9377-8

5. Adeghate E, Singh J. Structural changes in the myocardium during diabetes-induced cardiomyopathy. Heart Fail Rev. 2014;19(1):15-23. doi: https://doi.org/10.1007/s10741-013-9388-5

6. Al-Hamodi Z, Al-Habori M, Al-Meeri A, Saif-Ali R. Association of adipokines, leptin/adiponectin ratio and C-reactive protein with obesity and type 2 diabetes mellitus. Diabetol Metab Syndr. 2014;6(1):99. doi: https://doi.org/10.1186/1758-5996-6-99

7. Picu A, Petcu L, §tefan S, et al. Markers of oxidative stress and antioxidant defense in romanian patients with type 2 diabetes mellitus and obesity. Molecules. 2017;22(5):714. doi: https://doi.org/10.3390/molecules22050714

8. Stepien M, Rosniak-Bak K, Paradowski M, et al. Waist circumference, ghrelin and selected adipose tissue-derived adipokines as predictors of insulin resistance in obese patients: Preliminary results. MedSciMonit. 2011;17(11):PR13-18. doi: https://doi.org/10.12659/msm.882030

9. Niu M, Xiang L, Liu Y, et al. Adiponectin induced AMP-activated protein kinase impairment mediates insulin resistance in Bama minipig fed high-fat and high-sucrose diet. Asian-Australas J Anim Sci. 2017;30(8):1190-1197. doi: https://doi.org/10.5713/ajas.17.0006

10. Reinehr T, Woelfle J, Wiegand S, et al. Leptin but not adiponectin is related to type 2 diabetes mellitus in obese adolescents. Pediatr Diabetes. 2016;17(4):281-8. doi: https://doi.org/10.1111/pedi.12276

11. World Health Organization. Definition, diagnosis and classification of diabetes mellitus and its complications: report of a WHO consultation. Part 1, Diagnosis and classification of diabetes mellitus. Geneva. 1999;59

12. Bidulescu A, Dinh PC Jr, Sarwary S, et al. Associations of leptin and adiponectin with incident type 2 diabetes and interactions among African Americans: the Jackson heart study. BMC Endocr Disord. 2020;20(1):31. doi: https://doi.org/10.1186/s12902-020-0511-z

13. Ghadge AA, Khaire AA. Leptin as a predictive marker for metabolic syndrome. Cytokine. 2019;121:154735. doi: https://doi.org/10.1016/j.cyto.2019.154735

14. Lee K.W, Shin D. Prospective Associations of Serum Adiponectin, Leptin, and Leptin-Adiponectin Ratio with Incidence of Metabolic Syndrome: The Korean Genome and Epidemiology Study. Int. J. Environ. Res. Public Health. 2020;17:3287. doi: https://doi.org/10.3390/ijerph17093287

15. Smirnova EN, Shulkina SG. Leptin, soluble leptin receptor and the free leptin index in patients with metabolic syndrome. Obesity and metabolism. 2017;14(1):30-34. (in Russ). doi: https://doi.org/10.14341/OMET2017130-34

16. Hansen D, Dendale P, Beelen M, et al. Plasma adipokine and inflammatory marker concentrations are altered in obese, as opposed to non-obese, type 2 diabetes patients. Eur J Appl Physiol. 2010;109(3):397-404. doi: https://doi.org/10.1007/s00421-010-1362-5

17. Chearskul S, Sriwijitkamol A, Kooptiwut S, et al. Cardiometabolic risk in Thai adults with type 2 diabetes mellitus: obese versus non-obese. J Med Assoc Thai. 2015;98(6):528-34

18. Gonzalez N, Moreno-Villegas Z, Gonzalez-Bris A, et al. Regulation of visceral and epicardial adipose tissue for preventing cardiovascular injuries associated to obesity and diabetes. Cardiovasc Diabetol. 2017;16(1):44. doi: https://doi.org/10.1186/s12933-017-0528-4

19. Mishra AK, Dubey V, Ghosh AR. Obesity: An overview of possible role(s) of gut hormones, lipid sensing and gut microbiota. Metabolism. 2016;65(1):48-65. doi: https://doi.org/10.1016/j.metabol.2015.10.008

20. Nauck MA, Meier JJ. Incretin hormones: Their role in health and disease. Diabetes Obes Metab. 2018;20 Suppl 1:5-21. doi: https://doi.org/10.1111/dom.13129

21. Opinto G, Natalicchio A, Marchetti P. Physiology of incretins and loss of incretin effect in type 2 diabetes and obesity. Arch Physiol Biochem. 2013;119(4):170-8. doi: https://doi.org/10.3109/13813455.2013.812664

22. Stinson SE, Jonsson AE, Lund MAV, et al. Fasting Plasma GLP-1 Is Associated With Overweight/Obesity and Cardiometabolic Risk Factors in Children and Adolescents. J Clin Endocrinol Metab. 2021;106(6):1718-1727. doi: https://doi.org/10.1210/clinem/dgab098

23. Seon MJ, Hwang SY, Son Y, Song J, Kim OY. Circulating GLP-1 Levels as a Potential Indicator of Metabolic Syndrome Risk in Adult Women. Nutrients. 2021;13(3):865. doi: https://doi.org/10.3390/nu13030865

24. Chia CW, Carlson OD, Liu DD, et al. Incretin secretion in humans is under the influence of cannabinoid receptors. Am J Physiol Endocrinol Metab. 2017;313(3):E359-E366. doi: https://doi.org/10.1152/ajpendo.00080.2017

25. Bulgakova SV, Romanchuk NP, Treneva EV. Glyukagonopodobnyj peptid 1, golovnoj mozg, nejrodegenerativnye zabolevaniya: sovremennyj vzglyad // Byulleten' nauki i praktiki. 2020;6(4):153-172. (in Russ). doi: https://doi.org/10.33619/2414-2948/53/19


Review

For citations:


Kashtanova E.V., Polonskaya Ya.V., Shcherbakova L.V., Stakhneva E.M., Shramko V.S., Mustafina S.V., Khudyakova A.D., Ragino Yu.I. Associations of adupocutokine and metaboliv hormone level in young people aged 25-44 years with type 2 diabetes mellitus and abdominal obesity. Obesity and metabolism. 2024;21(1):14-23. (In Russ.) https://doi.org/10.14341/omet12974

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