The potential of DNA methylation markers in the study of obesity
A. F. Nikolaeva,
K. O. Petrova,
O. V. Vasyukova,
R. M. Guseinova,
I. R. Minniakhmetov,
R. I. Khusainova,
N. G. Mokrysheva,
V. O. Sigin https://doi.org/10.14341/omet13058
Abstract
Obesity is a complex, heterogeneous, actively progressive disease manifested by excessive formation of adipose tissue in the body and usually has a high cardiometabolic risk and specific complications. Currently, new data are emerging that explain the pathogenesis of obesity not only by genetic variations and imbalance between energy intake and expenditure, but also by the influence of epigenetic mechanisms, such as DNA methylation. DNA methylation is the most studied epigenetic modification, whose status in the cell can be altered by various external and internal environmental factors, including diet, lifestyle, and hormones. These changes may lead to dysregulation of genes responsible for metabolic processes associated with the development of obesity. However, studies investigating epigenetic marks as potential mediators of obesity are heterogeneous in design, methodology, and results. This review discusses a conceptual framework analyzing the relationship between DNA methylation, obesity, inflammation, and response to weight loss, including after bariatric surgery, as well as material selection and methodology issues to consider when designing studies in this area.
About the Authors
A. F. Nikolaeva
Research Centre for Medical Genetics
Russian Federation
Competing Interests:
Russian Federation
Aleksandra F. Nikolaeva
1 Moskvorechye st., 115522 Moscow
Competing Interests:
Работа выполнена в соавторстве с членом редакционной коллегии журнала «Ожирение и метаболизм» Н.Г. Мокрышевой
K. O. Petrova
Research Centre for Medical Genetics
Russian Federation
Competing Interests:
Russian Federation
Kristina O. Petrova
Moscow
Competing Interests:
Работа выполнена в соавторстве с членом редакционной коллегии журнала «Ожирение и метаболизм» Н.Г. Мокрышевой
O. V. Vasyukova
Endocrinology Research Centre
Russian Federation
Competing Interests:
Russian Federation
Olga V. Vasyukova - MD, PhD.
Moscow
Competing Interests:
Работа выполнена в соавторстве с членом редакционной коллегии журнала «Ожирение и метаболизм» Н.Г. Мокрышевой
R. M. Guseinova
Endocrinology Research Centre
Russian Federation
Competing Interests:
Russian Federation
Raisat M. Guseinova - MD; Scopus Author ID: 58077013800; Researcher ID: HDO-1221-2022.
Moscow
Competing Interests:
Работа выполнена в соавторстве с членом редакционной коллегии журнала «Ожирение и метаболизм» Н.Г. Мокрышевой
I. R. Minniakhmetov
Endocrinology Research Centre
Russian Federation
Competing Interests:
Russian Federation
Ildar R. Minniakhmetov - PhD in biology.
Moscow
Competing Interests:
Работа выполнена в соавторстве с членом редакционной коллегии журнала «Ожирение и метаболизм» Н.Г. Мокрышевой
R. I. Khusainova
Endocrinology Research Centre
Russian Federation
Competing Interests:
Russian Federation
Rita I. Khusainova - MD, PhD in biology.
Moscow
Competing Interests:
Работа выполнена в соавторстве с членом редакционной коллегии журнала «Ожирение и метаболизм» Н.Г. Мокрышевой
N. G. Mokrysheva
Endocrinology Research Centre
Russian Federation
Competing Interests:
Russian Federation
Natalia G. Mokrysheva - MD, PhD, Professor.
Moscow
Competing Interests:
Работа выполнена в соавторстве с членом редакционной коллегии журнала «Ожирение и метаболизм» Н.Г. Мокрышевой
V. O. Sigin
Research Centre for Medical Genetics
Russian Federation
Competing Interests:
Russian Federation
Vladimir O. Sigin - PhD in biology.
Moscow
Competing Interests:
Работа выполнена в соавторстве с членом редакционной коллегии журнала «Ожирение и метаболизм» Н.Г. Мокрышевой
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1. Figure 1. Summary of whole genome/wide genome methods for DNA methylation studies (adapted from Stirzaker C. et al., 2014). | |
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Nikolaeva A.F., Petrova K.O., Vasyukova O.V., Guseinova R.M., Minniakhmetov I.R., Khusainova R.I., Mokrysheva N.G., Sigin V.O. The potential of DNA methylation markers in the study of obesity. Obesity and metabolism. 2023;20(4):301-308. (In Russ.) https://doi.org/10.14341/omet13058
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