Influence of obesity on the formation and development of cancer. Obesity and metabolism
https://doi.org/10.14341/omet13025
Abstract
It has now been shown that overweight and obesity are associated with the development of at least 13 types of cancer, including cancer of the breast, colon and rectum, endometrium, esophagus (adenocarcinoma), gallbladder, stomach, kidney (renal cell), liver, ovaries, pancreas and thyroid glands, as well as multiple myeloma. Obesity-related cancers account for about 40% of all cancers. Thus, obesity is ahead of smoking as the most common modifiable risk factor for carcinogenesis. This review collects the latest data on the impact of obesity phenotypes on the risk of developing cancer, including a discussion of the contribution of the metabolically healthy obesity phenotype (MHO) to tumorigenesis. Possible mechanisms contributing to the emergence and progression of cancer are analyzed, for example: stimulation of cell proliferation, evasion of growth suppressors, inhibition of apoptosis and provision of replicative immortality, induction of angiogenesis, activation of invasion and metastasis, influence on genome instability, as well as chronic low-grade inflammation that contributes to the development of cancer. Understanding how obesity influences the above mechanisms may facilitate the development of new cancer prevention and treatment strategies for obese populations.
About the Authors
S. V. Mustafina
Research Institute of Internal and Preventive Medicine Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Svetlana V. Mustafina, MD, PhD, DSc
Novosibirsk
D. A. Vinter
Research Institute of Internal and Preventive Medicine Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Darya A. Vinter, MD, PhD
Novosibirsk
V. I. Alferova
Research Institute of Internal and Preventive Medicine Branch of the Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences
Russian Federation
Russian Federation
Vlada I. Alferova, MD, PhD
175/1, Borisa Bogatkova street, 630089 Novosibirsk
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Supplementary files
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1. Figure 1. Relationship between leptin and adiponectin in the context of tumorigenesis (adapted from Harris B. et al. [20]). | |
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Mustafina S.V., Vinter D.A., Alferova V.I. Influence of obesity on the formation and development of cancer. Obesity and metabolism. Obesity and metabolism. 2024;21(2):205-214. (In Russ.) https://doi.org/10.14341/omet13025
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