The role of the apelin/APJ system in water homeostasis regulation
https://doi.org/10.14341/omet12752
Abstract
Water balance in the body is achieved by balancing renal and non-renal water losses with corresponding water intake. It is under the control of both the central nervous system, which integrates many parameters of water and electrolyte balance in the body, including inducing important adaptive behavioral responses, and three hormonal systems: vasopressinergic, renin-angiotensin-aldosterone and apelinergic. A lot of research is devoted to the regulation of water-electrolyte metabolism. However, this process is still quite difficult to understand, especially since more and more of its regulators are being discovered over time. One of them is the hormone apelin, an endogenous ligand for the APJ receptor. As is known, the receptor is highly expressed in many organs, such as the brain, heart, liver and kidneys, lungs, and has multidirectional effects.
This literature review discusses the main characteristics and features of the regulation of these systems in relation to water-electrolyte metabolism, as well as issues of intersystem interaction and modulation of the effects of apelin.
About the Authors
Kh. R. Fargieva
Endocrinology Research Centre
Russian Federation
Russian Federation
Khava R. Fargieva, MD, postgraduate student
Moscow
eLibrary SPIN: 3476-5134
R. M. Guseinova
Endocrinology Research Centre
Raisat M. Guseinova, MD
Moscow
eLibrary SPIN: 9719-3850
E. A. Pigarova
Endocrinology Research Centre
Ekaterina A. Pigarova, MD, PhD
Moscow
Scopus Author ID 55655098500;
Researcher ID: T-9424-2018;
eLibrary SPIN: 6912-6331
L. K. Dzeranova
Endocrinology Research Centre
Larisa K. Dzeranova, MD, PhD
Moscow
eLibrary SPIN: 2958-5555
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1. Figure 1. (A) Structure of the precursor of apelin, 77-amino acid preproapelin. (B) Amino acid sequences of (a) apelin-36, (b) apelin-17, (c) apelin-13, and (d) [Pyr1]apelin-13. Angiotensin converting enzyme 2 (ACE 2) can hydrolyze apelin-13 and apelin-36, removing the C-terminal residue. | |
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2. Figure 2. Anatomy of the hypothalamic-pituitary region. | |
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Fargieva Kh.R., Guseinova R.M., Pigarova E.A., Dzeranova L.K. The role of the apelin/APJ system in water homeostasis regulation. Obesity and metabolism. 2022;19(3):340-347. (In Russ.) https://doi.org/10.14341/omet12752
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