ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/omet9963ometendo-9963Research ArticleОбзор литературыReviewИнтеракции между нарушениями сна, ожирением и сахарным диабетом 2 типаSleep disorders interactions with obesity and type 2 diabeteshttps://orcid.org/0000-0002-2847-4422БродовскаяТатьяна ОлеговнаBrodovskayaTatyana O.

к.м.н.

MD, PhD

tbrod80@gmail.comhttps://orcid.org/0000-0002-9004-3711ГришинаИрина ФедоровнаGrishinaIrina F.

д.м.н., профессор

MD, PhD, professor

Grishina@edc.nexcom.ruhttps://orcid.org/0000-0001-8991-8165БабыкинаЕвгения ГеоргиевнаBabykinaGenia G.

PhD

PhD in Mathematics

evgeniya.babykina@univ-lille.frНиколаенкоОльга ВладимировнаNikolaenkoOlga V.

к.м.н., доцент

MD, PhD, associate professor

nickol4@yandex.ruhttps://orcid.org/0000-0002-4208-4658КовинЕгор АндреевичKovinEgor A.

ординатор

MD, resident

eakovin@inbox.ruhttps://orcid.org/0000-0001-7821-3004БаженоваОксана ВикторовнаBazhenovaOxana V.

ассистент кафедры

MD, assistant

roxanaross@yandex.ruhttps://orcid.org/0000-0003-0923-5888БересневаВалерия ЭдуардовнаBeresnevaValeria E.

MD

veber1813@mail.ruhttps://orcid.org/0000-0003-4920-2001БухароваСофья ЮрьевнаBuharovaSofia Y.buharova007@yandex.ruУральский государственный медицинский университетРоссияUrals State Medical UniversityRussian FederationУниверситет ЛилляФранцияUniversite de LilleFrance2019251220191642530Copyright © Бродовская Т.О., Гришина И.Ф., Бабыкина Е.Г., Николаенко О.В., Ковин Е.А., Баженова О.В., Береснева В.Э., Бухарова С.Ю., 20192019Бродовская Т.О., Гришина И.Ф., Бабыкина Е.Г., Николаенко О.В., Ковин Е.А., Баженова О.В., Береснева В.Э., Бухарова С.Ю.Brodovskaya T.O., Grishina I.F., Babykina G.G., Nikolaenko O.V., Kovin E.A., Bazhenova O.V., Beresneva V.E., Buharova S.Y.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/9963

Ожирение и сахарный диабет 2 типа (СД2) являются пандемией XXI в. Данные патологические состояния находятся в фокусе внимания врачей разных специальностей: кардиологов, эндокринологов, диетологов, терапевтов и других. Высокая частота развития сердечно-сосудистых осложнений ожирения и СД2, таких как инфаркт миокарда, инсульт, хроническая сердечная недостаточность, деменция, определяют необходимость поиска факторов риска развития указанных метаболических нарушений. К числу модифицируемых факторов могут относиться нарушения сна. Исследования последних лет выявили связь между изменением длительности сна и нарушениями обмена веществ. Однако до настоящего времени не установлены механизмы, находящиеся в основе такой ассоциации. Целями обзора являются обобщение существующих эпидемиологических и экспериментальных наблюдений, а также анализ возможных патофизиологических механизмов, связывающих продолжительность сна с ожирением и СД2. В работе рассматриваются современные данные, предполагающие двунаправленную ассоциацию нарушений сна с ожирением и сахарным диабетом. Патология сна может являться значимой детерминантой риска развития метаболических расстройств. А коррекцию продолжительности сна можно рассматривать в качестве терапевтической мишени для профилактики развития сердечно-сосудистых осложнений ожирения и СД2.

Obesity and type II diabetes are 21st century pandemia. These metаbolic disorders are in the focus of attention of various specialties: cardiologists, endocrinologists, nutritionists, therapists, and others. The high incidence of obesity and type II diabetes cardiovascular complications, such as myocardial infarction, stroke, chronic heart failure, dementia, determine the call of risk factors search. Modifiable factors may include sleep disturbances. Recent studies have revealed a connection between changes in sleep duration and metabolic disorders. However, to date, the mechanisms underlying this association have not been established. The aim of the review is to summarize existing epidemiological and experimental observations, as well as an analysis of possible pathophysiological mechanisms linking sleep duration with obesity and type II diabetes. The article considers current data suggesting a bi-directional association of sleep disorders with obesity and diabetes. Sleep disturbances are significant determinant of developing metabolic disorders. Sleep duration correction as one of therapeutic targets for cardiovascular complications of obesity and type II diabetes prevention.

ожирениесахарный диабет 2 типанарушения снаапноэбессонницапродолжительность снаobesitytype 2 diabetessleep disordersapneainsomniasleep durationReferencesPatel SR, Malhotra A, Gottlieb DJ, et al. Correlates of Long Sleep Duration. Sleep. 2006;29(7):881-889. DOI:10.1093/sleep/29.7.881Patel SR, Malhotra A, Gottlieb DJ, et al. Correlates of Long Sleep Duration. Sleep. 2006;29(7):881-889. DOI:10.1093/sleep/29.7.881Cai H, Shu XO, Xiang YB, et al. Sleep duration and mortality: a prospective study of 113 138 middle-aged and elderly Chinese men and women. Sleep. 2015;38(4):529-536. DOI:10.5665/sleep.4564Cai H, Shu XO, Xiang YB, et al. Sleep duration and mortality: a prospective study of 113 138 middle-aged and elderly Chinese men and women. Sleep. 2015;38(4):529-536. DOI:10.5665/sleep.4564Theorell-Haglow J, Berglund L, Berne C, Lindberg E. Both habitual short sleepers and long sleepers are at greater risk of obesity: a population-based 10-year follow-up in women. Sleep Med. 2014;15(10):1204-1211. DOI:10.1016/j.sleep.2014.02.014Theorell-Haglow J, Berglund L, Berne C, Lindberg E. Both habitual short sleepers and long sleepers are at greater risk of obesity: a population-based 10-year follow-up in women. Sleep Med. 2014;15(10):1204-1211. DOI:10.1016/j.sleep.2014.02.014Shan Z, Ma H, Xie M, et al. Sleep duration and risk of type 2 diabetes: a meta-analysis of prospective studies. Diabetes Care. 2015;38(3):529-537. DOI:10.2337/dc14-2073Shan Z, Ma H, Xie M, et al. Sleep duration and risk of type 2 diabetes: a meta-analysis of prospective studies. Diabetes Care. 2015;38(3):529-537. DOI:10.2337/dc14-2073Broussard JL, Ehrmann DA, Van Cauter E, et al. Impaired insulin signaling in human adipocytes after experimental sleep restriction: a randomized, crossover study. Ann Intern Med. 2012;157(8):549-557. DOI:10.7326/0003-4819-157-8-201210160-00005Broussard JL, Ehrmann DA, Van Cauter E, et al. Impaired insulin signaling in human adipocytes after experimental sleep restriction: a randomized, crossover study. Ann Intern Med. 2012;157(8):549-557. DOI:10.7326/0003-4819-157-8-201210160-00005Taheri S, Lin L, Austin D, et al. Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index. PLoS Med. 2004;1(3):e62. DOI:10.1371/journal.pmed.0010062Taheri S, Lin L, Austin D, et al. Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index. PLoS Med. 2004;1(3):e62. DOI:10.1371/journal.pmed.0010062Bjorvatn B, Sagen IM, Oyane N, et al. The association between sleep duration, body mass index and metabolic measures in the Hordaland Health Study. J Sleep Res. 2007;16(1):66-76. DOI:10.1111/j.1365-2869.2007.00569.xBjorvatn B, Sagen IM, Oyane N, et al. The association between sleep duration, body mass index and metabolic measures in the Hordaland Health Study. J Sleep Res. 2007;16(1):66-76. DOI:10.1111/j.1365-2869.2007.00569.xChaput JP, Despres JP, Bouchard C, Tremblay A. Short sleep duration is associated with reduced leptin levels and increased adiposity: Results from the Quebec family study. Obesity (Silver Spring). 2007;15(1):253-261. DOI:10.1038/oby.2007.512Chaput JP, Despres JP, Bouchard C, Tremblay A. Short sleep duration is associated with reduced leptin levels and increased adiposity: Results from the Quebec family study. Obesity (Silver Spring). 2007;15(1):253-261. DOI:10.1038/oby.2007.512van den Berg JF, Knvistingh Neven A, Tulen JH, et al. Actigraphic sleep duration and fragmentation are related to obesity in the elderly: the Rotterdam Study. Int J Obes (Lond). 2008;32(7):1083-1090. DOI:10.1038/ijo.2008.57van den Berg JF, Knvistingh Neven A, Tulen JH, et al. Actigraphic sleep duration and fragmentation are related to obesity in the elderly: the Rotterdam Study. Int J Obes (Lond). 2008;32(7):1083-1090. DOI:10.1038/ijo.2008.57Chaput JP, Despres JP, Bouchard C, Tremblay A. The association between sleep duration and weight gain in adults: a 6-year prospective study from the Quebec Family Study. Sleep. 2008;31(4):517-523. DOI:10.1093/sleep/31.4.517Chaput JP, Despres JP, Bouchard C, Tremblay A. The association between sleep duration and weight gain in adults: a 6-year prospective study from the Quebec Family Study. Sleep. 2008;31(4):517-523. DOI:10.1093/sleep/31.4.517Vgontzas AN, Lin HM, Papaliaga M, et al. Short sleep duration and obesity: the role of emotional stress and sleep disturbances. Int J Obes (Lond). 2008;32(5):801-809. DOI:10.1038/ijo.2008.4Vgontzas AN, Lin HM, Papaliaga M, et al. Short sleep duration and obesity: the role of emotional stress and sleep disturbances. Int J Obes (Lond). 2008;32(5):801-809. DOI:10.1038/ijo.2008.4Xiao Q, Arem H, Moore SC, et al. A large prospective investigation of sleep duration, weight change, and obesity in the NIH-AARP Diet and Health Study cohort. Am J Epidemiol. 2013;178(11):1600-1610. DOI:10.1093/aje/kwt180Xiao Q, Arem H, Moore SC, et al. A large prospective investigation of sleep duration, weight change, and obesity in the NIH-AARP Diet and Health Study cohort. Am J Epidemiol. 2013;178(11):1600-1610. DOI:10.1093/aje/kwt180Marshall NS, Glozier N, Grunstein RR. Is sleep duration related to obesity? A critical review of the epidemiological evidence. Sleep Med Rev. 2008;12(4):289-298. DOI:10.1016/j.smrv.2008.03.001Marshall NS, Glozier N, Grunstein RR. Is sleep duration related to obesity? A critical review of the epidemiological evidence. Sleep Med Rev. 2008;12(4):289-298. DOI:10.1016/j.smrv.2008.03.001Ayas NT, White DP, Al-Delaimy WK, et al. A prospective study of self-reported sleep duration and incident diabetes in women. Diabetes Care. 2003;26(2):380-384. DOI:10.2337/diacare.26.2.380Ayas NT, White DP, Al-Delaimy WK, et al. A prospective study of self-reported sleep duration and incident diabetes in women. Diabetes Care. 2003;26(2):380-384. DOI:10.2337/diacare.26.2.380Yaggi HK, Araujo AB, McKinlay JB. Sleep duration as a risk factor for the development of type 2 diabetes. Diabetes Care. 2006;29(3):657-661. DOI:10.2337/diacare.29.03.06.dc05-0879Yaggi HK, Araujo AB, McKinlay JB. Sleep duration as a risk factor for the development of type 2 diabetes. Diabetes Care. 2006;29(3):657-661. DOI:10.2337/diacare.29.03.06.dc05-0879Cappuccio FP, D’Elia L, Strazzullo P, Miller MA. Quantity and quality of sleep and incidence of type 2 diabetes: a systematic review and meta-analysis. Diabetes Care. 2010;33(2):414-420. DOI:10.2337/dc09-1124Cappuccio FP, D’Elia L, Strazzullo P, Miller MA. Quantity and quality of sleep and incidence of type 2 diabetes: a systematic review and meta-analysis. Diabetes Care. 2010;33(2):414-420. DOI:10.2337/dc09-1124Cespedes EM, Bhupathiraju SN, Li Y, et al. Long-term changes in sleep duration, energy balance and risk of type 2 diabetes. Diabetologia. 2016;59(1):101-109. DOI:10.1007/s00125-015-3775-5Cespedes EM, Bhupathiraju SN, Li Y, et al. Long-term changes in sleep duration, energy balance and risk of type 2 diabetes. Diabetologia. 2016;59(1):101-109. DOI:10.1007/s00125-015-3775-5Rahe C, Czira ME, Teismann H, Berger K. Associations between poor sleep quality and different measures of obesity. Sleep Med. 2015;16(10):1225-1228. DOI:10.1016/j.sleep.2015.05.023Rahe C, Czira ME, Teismann H, Berger K. Associations between poor sleep quality and different measures of obesity. Sleep Med. 2015;16(10):1225-1228. DOI:10.1016/j.sleep.2015.05.023Grimaldi D, Beccuti G, Touma C, et al. Association of obstructive sleep apnea in rapid eye movement sleep with reduced glycemic control in type 2 diabetes: therapeutic implications. Diabetes Care. 2014;37(2):355-363. DOI:10.2337/dc13-0933Grimaldi D, Beccuti G, Touma C, et al. Association of obstructive sleep apnea in rapid eye movement sleep with reduced glycemic control in type 2 diabetes: therapeutic implications. Diabetes Care. 2014;37(2):355-363. DOI:10.2337/dc13-0933Бродовская Т.О., Ковин Е.А., Баженова О.В., и др. Предикторы висцерального ожирения у Пациентов с синдромом обструктивного апноэ сна и нормальной массой тела. // Ожирение и метаболизм. — 2019. — Т. 16. — №2. — С. 29-35. [Brodovskaya TO, Kovin EA, Bazhenova OV, et al. Predictors of visceral obesity in normal weight obstructive sleep apnea patients. Obesity and metabolism. 2019;16(2):29-35. (In Russ.)] DOI:10.14341/omet97374Бродовская Т.О., Ковин Е.А., Баженова О.В., и др. Предикторы висцерального ожирения у Пациентов с синдромом обструктивного апноэ сна и нормальной массой тела. // Ожирение и метаболизм. — 2019. — Т. 16. — №2. — С. 29-35. [Brodovskaya TO, Kovin EA, Bazhenova OV, et al. Predictors of visceral obesity in normal weight obstructive sleep apnea patients. Obesity and metabolism. 2019;16(2):29-35. (In Russ.)] DOI:10.14341/omet97374Stamatakis KA, Punjabi NM. Effects of sleep fragmentation on glucose metabolism in normal subjects. Chest. 2010;137(1):95-101. DOI:10.1378/chest.09-0791Stamatakis KA, Punjabi NM. Effects of sleep fragmentation on glucose metabolism in normal subjects. Chest. 2010;137(1):95-101. DOI:10.1378/chest.09-0791Gonnissen HK, Hursel R, Rutters F, et al. Effects of sleep fragmentation on appetite and related hormone concentrations over 24 h in healthy men. Br J Nutr. 2013;109(4):748-756. DOI:10.1017/S0007114512001894Gonnissen HK, Hursel R, Rutters F, et al. Effects of sleep fragmentation on appetite and related hormone concentrations over 24 h in healthy men. Br J Nutr. 2013;109(4):748-756. DOI:10.1017/S0007114512001894Lakerveld J, Mackenbach JD, Horvath E, et al. The relation between sleep duration and sedentary behaviours in European adults. Obes Rev. 2016;17 Suppl 1:62-67. DOI:10.1111/obr.12381Lakerveld J, Mackenbach JD, Horvath E, et al. The relation between sleep duration and sedentary behaviours in European adults. Obes Rev. 2016;17 Suppl 1:62-67. DOI:10.1111/obr.12381Kronholm E, Harma M, Hublin C, et al. Self-reported sleep duration in Finnish general population. J Sleep Res. 2006;15(3):276-290. DOI:10.1111/j.1365-2869.2006.00543.xKronholm E, Harma M, Hublin C, et al. Self-reported sleep duration in Finnish general population. J Sleep Res. 2006;15(3):276-290. DOI:10.1111/j.1365-2869.2006.00543.xHolloszy JO. Exercise-induced increase in muscle insulin sensitivity. J Appl Physiol (1985). 2005;99(1):338-343. DOI:10.1152/japplphysiol.00123.2005Holloszy JO. Exercise-induced increase in muscle insulin sensitivity. J Appl Physiol (1985). 2005;99(1):338-343. DOI:10.1152/japplphysiol.00123.2005Solomon TP, Haus JM, Kelly KR, et al. Improved pancreatic beta-cell function in type 2 diabetic patients after lifestyle-induced weight loss is related to glucose-dependent insulinotropic polypeptide. Diabetes Care. 2010;33(7):1561-1566. DOI:10.2337/dc09-2021Solomon TP, Haus JM, Kelly KR, et al. Improved pancreatic beta-cell function in type 2 diabetic patients after lifestyle-induced weight loss is related to glucose-dependent insulinotropic polypeptide. Diabetes Care. 2010;33(7):1561-1566. DOI:10.2337/dc09-2021Kirchner H, Osler ME, Krook A, Zierath JR. Epigenetic flexibility in metabolic regulation: disease cause and prevention? Trends Cell Biol. 2013;23(5):203-209. DOI:10.1016/j.tcb.2012.11.008Kirchner H, Osler ME, Krook A, Zierath JR. Epigenetic flexibility in metabolic regulation: disease cause and prevention? Trends Cell Biol. 2013;23(5):203-209. DOI:10.1016/j.tcb.2012.11.008Febbraio MA, Hiscock N, Sacchetti M, et al. Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction. Diabetes. 2004;53(7):1643-1648. DOI:10.2337/diabetes.53.7.1643Febbraio MA, Hiscock N, Sacchetti M, et al. Interleukin-6 is a novel factor mediating glucose homeostasis during skeletal muscle contraction. Diabetes. 2004;53(7):1643-1648. DOI:10.2337/diabetes.53.7.1643Jedrychowski MP, Wrann CD, Paulo JA, et al. Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry. Cell Metab. 2015;22(4):734-740. DOI:10.1016/j.cmet.2015.08.001Jedrychowski MP, Wrann CD, Paulo JA, et al. Detection and Quantitation of Circulating Human Irisin by Tandem Mass Spectrometry. Cell Metab. 2015;22(4):734-740. DOI:10.1016/j.cmet.2015.08.001Carey AL, Steinberg GR, Macaulay SL, et al. Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase. Diabetes. 2006;55(10):2688-2697. DOI:10.2337/db05-1404Carey AL, Steinberg GR, Macaulay SL, et al. Interleukin-6 increases insulin-stimulated glucose disposal in humans and glucose uptake and fatty acid oxidation in vitro via AMP-activated protein kinase. Diabetes. 2006;55(10):2688-2697. DOI:10.2337/db05-1404Ellingsgaard H, Hauselmann I, Schuler B, et al. Interleukin-6 enhances insulin secretion by increasing glucagonlike peptide-1 secretion from L cells and alpha cells. Nat Med. 2011;17(11):1481-1489. DOI:10.1038/nm.2513Ellingsgaard H, Hauselmann I, Schuler B, et al. Interleukin-6 enhances insulin secretion by increasing glucagonlike peptide-1 secretion from L cells and alpha cells. Nat Med. 2011;17(11):1481-1489. DOI:10.1038/nm.2513Nybo L, Nielsen B, Klarlund Pedersen B, et al. Interleukin-6 release from the human brain during prolonged exercise. J Physiol. 2002;542(3):991-995. DOI:10.1113/jphysiol.2002.022285Nybo L, Nielsen B, Klarlund Pedersen B, et al. Interleukin-6 release from the human brain during prolonged exercise. J Physiol. 2002;542(3):991-995. DOI:10.1113/jphysiol.2002.022285Sadagurski M, Norquay L, Farhang J, et al. Human IL6 enhances leptin action in mice. Diabetologia. 2010;53(3):525-535. DOI:10.1007/s00125-009-1580-8Sadagurski M, Norquay L, Farhang J, et al. Human IL6 enhances leptin action in mice. Diabetologia. 2010;53(3):525-535. DOI:10.1007/s00125-009-1580-8Bostreom P, Wu J, Jedrychowski MP, et al. Faculty of 1000 evaluation for A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature. 2012;481(7382):463-468. DOI:10.1038/nature10777Bostreom P, Wu J, Jedrychowski MP, et al. Faculty of 1000 evaluation for A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. Nature. 2012;481(7382):463-468. DOI:10.1038/nature10777Kant AK, Graubard BI. Association of self-reported sleep duration with eating behaviors of American adults: NHANES 2005-2010. Am J Clin Nutr. 2014;100(3):938-947. DOI:10.3945/ajcn.114.085191Kant AK, Graubard BI. Association of self-reported sleep duration with eating behaviors of American adults: NHANES 2005-2010. Am J Clin Nutr. 2014;100(3):938-947. DOI:10.3945/ajcn.114.085191Berg C, Forslund HB. The Influence of Portion Size and Timing of Meals on Weight Balance and Obesity. Curr Obes Rep. 2015;4(1):11-18. DOI:10.1007/s13679-015-0138-yBerg C, Forslund HB. The Influence of Portion Size and Timing of Meals on Weight Balance and Obesity. Curr Obes Rep. 2015;4(1):11-18. DOI:10.1007/s13679-015-0138-yGrandner MA, Jackson N, Gerstner JR, Knutson KL. Dietary nutrients associated with short and long sleep duration. Data from a nationally representative sample. Appetite. 2013;64:71-80. DOI:10.1016/j.appet.2013.01.004Grandner MA, Jackson N, Gerstner JR, Knutson KL. Dietary nutrients associated with short and long sleep duration. Data from a nationally representative sample. Appetite. 2013;64:71-80. DOI:10.1016/j.appet.2013.01.004Carole W, Sherry L, Taasan VC, et al. Alcohol increases sleep apnea and oxygen desaturation in asymptomatic men. Am J Med. 1981;71(2):240-245. DOI:10.1016/0002-9343(81)90124-8Carole W, Sherry L, Taasan VC, et al. Alcohol increases sleep apnea and oxygen desaturation in asymptomatic men. Am J Med. 1981;71(2):240-245. DOI:10.1016/0002-9343(81)90124-8Martinez-Ceron E, Fernandez-Navarro I, Garcia-Rio F. Effects of continuous positive airway pressure treatment on glucose metabolism in patients with obstructive sleep apnea. Sleep Med Rev. 2016;25:121-130. DOI:10.1016/j.smrv.2015.03.002Martinez-Ceron E, Fernandez-Navarro I, Garcia-Rio F. Effects of continuous positive airway pressure treatment on glucose metabolism in patients with obstructive sleep apnea. Sleep Med Rev. 2016;25:121-130. DOI:10.1016/j.smrv.2015.03.002Luppino FS, de Wit LM, Bouvy PF, et al. Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies. Arch Gen Psychiatry. 2010;67(3):220-229. DOI:10.1001/archgenpsychiatry.2010.2Luppino FS, de Wit LM, Bouvy PF, et al. Overweight, obesity, and depression: a systematic review and meta-analysis of longitudinal studies. Arch Gen Psychiatry. 2010;67(3):220-229. DOI:10.1001/archgenpsychiatry.2010.2Pan A, Lucas M, Sun Q, et al. Bidirectional association between depression and type 2 diabetes mellitus in women. Arch Intern Med. 2010;170(21):1884-1891. DOI:10.1001/archinternmed.2010.356Pan A, Lucas M, Sun Q, et al. Bidirectional association between depression and type 2 diabetes mellitus in women. Arch Intern Med. 2010;170(21):1884-1891. DOI:10.1001/archinternmed.2010.356Kotsis V, Stabouli S, Papakatsika S, et al. Mechanisms of obesity-induced hypertension. Hypertens Res. 2010;33(5):386-393. DOI:10.1038/hr.2010.9Kotsis V, Stabouli S, Papakatsika S, et al. Mechanisms of obesity-induced hypertension. Hypertens Res. 2010;33(5):386-393. DOI:10.1038/hr.2010.9Van Buren PN, Toto R. Hypertension in diabetic nephropathy: epidemiology, mechanisms, and management. Adv Chronic Kidney Dis. 2011;18(1):28-41. DOI:10.1053/j.ackd.2010.10.003Van Buren PN, Toto R. Hypertension in diabetic nephropathy: epidemiology, mechanisms, and management. Adv Chronic Kidney Dis. 2011;18(1):28-41. DOI:10.1053/j.ackd.2010.10.003Ohayon MM, Roth T. Place of chronic insomnia in the course of depressive and anxiety disorders. Journal of Psychiatric Research. 2003;37(1):9-15. DOI:10.1016/s0022-3956(02)00052-3Ohayon MM, Roth T. Place of chronic insomnia in the course of depressive and anxiety disorders. Journal of Psychiatric Research. 2003;37(1):9-15. DOI:10.1016/s0022-3956(02)00052-3Gottlieb DJ, Redline S, Nieto FJ, et al. Association of usual sleep duration with hypertension: the Sleep Heart Health Study. Sleep. 2006;29(8):1009-1014. DOI:10.1093/sleep/29.8.1009Gottlieb DJ, Redline S, Nieto FJ, et al. Association of usual sleep duration with hypertension: the Sleep Heart Health Study. Sleep. 2006;29(8):1009-1014. DOI:10.1093/sleep/29.8.1009Konecny T, Kara T, Somers VK. Obstructive sleep apnea and hypertension: an update. Hypertension. 2014;63(2):203-209. DOI:10.1161/HYPERTENSIONAHA.113.00613Konecny T, Kara T, Somers VK. Obstructive sleep apnea and hypertension: an update. Hypertension. 2014;63(2):203-209. DOI:10.1161/HYPERTENSIONAHA.113.00613Broussard JL, Wroblewski K, Kilkus JM, Tasali E. Two Nights of Recovery Sleep Reverses the Effects of Short-term Sleep Restriction on Diabetes Risk. Diabetes Care. 2016;39(3):e40-41. DOI:10.2337/dc15-2214Broussard JL, Wroblewski K, Kilkus JM, Tasali E. Two Nights of Recovery Sleep Reverses the Effects of Short-term Sleep Restriction on Diabetes Risk. Diabetes Care. 2016;39(3):e40-41. DOI:10.2337/dc15-2214Xie L, Kang H, Xu Q, et al. Sleep drives metabolite clearance from the adult brain. Science. 2013;342(6156):373-377. DOI:10.1126/science.1241224Xie L, Kang H, Xu Q, et al. Sleep drives metabolite clearance from the adult brain. Science. 2013;342(6156):373-377. DOI:10.1126/science.1241224Cedernaes J, Osorio RS, Varga AW, et al. Candidate mechanisms underlying the association between sleep-wake disruptions and Alzheimer’s disease. Sleep Med Rev. 2017;31:102-111. DOI:10.1016/j.smrv.2016.02.002Cedernaes J, Osorio RS, Varga AW, et al. Candidate mechanisms underlying the association between sleep-wake disruptions and Alzheimer’s disease. Sleep Med Rev. 2017;31:102-111. DOI:10.1016/j.smrv.2016.02.002Jiang Q, Zhang L, Ding G, et al. Impairment of the glymphatic system after diabetes. J Cereb Blood Flow Metab. 2017;37(4):1326-1337. DOI:10.1177/0271678X16654702Jiang Q, Zhang L, Ding G, et al. Impairment of the glymphatic system after diabetes. J Cereb Blood Flow Metab. 2017;37(4):1326-1337. DOI:10.1177/0271678X16654702

The authors declare that there are no conflicts of interest present.