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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ometendo</journal-id><journal-title-group><journal-title xml:lang="ru">Ожирение и метаболизм</journal-title><trans-title-group xml:lang="en"><trans-title>Obesity and metabolism</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2071-8713</issn><issn pub-type="epub">2306-5524</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/omet9834</article-id><article-id custom-type="elpub" pub-id-type="custom">ometendo-9834</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Лекция</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Lecture</subject></subj-group></article-categories><title-group><article-title>Диагностика и лечение эндокринологических осложнений иммунотерапии онкологических заболеваний</article-title><trans-title-group xml:lang="en"><trans-title>Diagnosis and treatment of endocrinological complications of immunotherapy of oncological diseases</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6539-466X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пигарова</surname><given-names>Екатерина Александровна</given-names></name><name name-style="western" xml:lang="en"><surname>Pigarova</surname><given-names>Ekaterina A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н.</p></bio><bio xml:lang="en"><p>MD, PhD</p></bio><email xlink:type="simple">kpigarova@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-0327-4619</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Дзеранова</surname><given-names>Лариса Константиновна</given-names></name><name name-style="western" xml:lang="en"><surname>Dzeranova</surname><given-names>Larisa K.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н.</p></bio><bio xml:lang="en"><p>MD, PhD</p></bio><email xlink:type="simple">dzeranovalk@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0001-6876-3336</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Нуралиева</surname><given-names>Нурана Фейзуллаевна</given-names></name><name name-style="western" xml:lang="en"><surname>Nuralieva</surname><given-names>Nurana F.</given-names></name></name-alternatives><bio xml:lang="ru"><p>научный сотрудник</p></bio><bio xml:lang="en"><p>MD</p></bio><email xlink:type="simple">dr.nuralievanf@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-5634-7877</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Мельниченко</surname><given-names>Галина Афанасьевна</given-names></name><name name-style="western" xml:lang="en"><surname>Mel`nichenko</surname><given-names>Galina A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., профессор, академик РАН</p></bio><bio xml:lang="en"><p>MD, PhD, Professor</p></bio><email xlink:type="simple">teofrast2000@mail.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>&lt;p&gt;ФГБУ &amp;laquo;Национальный медицинский исследовательский центр эндокринологии&amp;raquo; Минздрава России&lt;/p&gt;</institution><country>Россия</country></aff><aff xml:lang="en"><institution>&lt;p&gt;Endocrinology Research Centre&lt;/p&gt;</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2018</year></pub-date><pub-date pub-type="epub"><day>23</day><month>11</month><year>2018</year></pub-date><volume>15</volume><issue>3</issue><fpage>49</fpage><lpage>58</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Пигарова Е.А., Дзеранова Л.К., Нуралиева Н.Ф., Мельниченко Г.А., 2018</copyright-statement><copyright-year>2018</copyright-year><copyright-holder xml:lang="ru">Пигарова Е.А., Дзеранова Л.К., Нуралиева Н.Ф., Мельниченко Г.А.</copyright-holder><copyright-holder xml:lang="en">Pigarova E.A., Dzeranova L.K., Nuralieva N.F., Mel`nichenko G.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.omet-endojournals.ru/jour/article/view/9834">https://www.omet-endojournals.ru/jour/article/view/9834</self-uri><abstract><p>В этой лекции подробно рассматриваются эндокринопатии, связанные с применением ингибиторов иммунных конечных точек при онкологических заболеваниях, обсуждаются случаи, сроки и особенности клинических проявлений, предлагаются практические рекомендации для лечения пациентов.</p></abstract><trans-abstract xml:lang="en"><p>In this lecture, we discuss in detail the endocrinopathies associated with the use of immune-checkpoint inhibitors in oncology. The cases, terms and features of clinical manifestations of endocrine-related immune reactions are discussed, and practical recommendations for the treatment of patients are proposed.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ингибиторы иммунных конечных точек</kwd><kwd>ипилимумаб</kwd><kwd>ниволумаб</kwd><kwd>эндокринопатии</kwd><kwd>аутоиммунные заболевания</kwd><kwd>нежелательные явления</kwd><kwd>тиреоидит</kwd><kwd>гипофизит</kwd><kwd>надпочечниковая недостаточность</kwd><kwd>адреналит</kwd><kwd>гипотиреоз</kwd><kwd>меланома</kwd><kwd>рак легкого</kwd></kwd-group><kwd-group xml:lang="en"><kwd>immune-checkpoint inhibitors</kwd><kwd>ipilimumab</kwd><kwd>nivolumab</kwd><kwd>endocrinopathies</kwd><kwd>autoimmune diseases</kwd><kwd>adverse effects</kwd><kwd>thyroiditis</kwd><kwd>pituitary</kwd><kwd>adrenal insufficiency</kwd><kwd>adrenalitis</kwd><kwd>hypothyroidism</kwd><kwd>melanoma</kwd><kwd>lung cancer</kwd><kwd>CTLA-4</kwd><kwd>PD-1</kwd></kwd-group><funding-group><funding-statement xml:lang="ru">Выполнено за счет гранта Российского научного фонда (проект 17-75-30035)</funding-statement></funding-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Spain L, Diem S, Larkin J. 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