ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/omet9745ometendo-9745Research ArticleОбзор литературыReviewОжирение и инфекция. Еще одна коморбидность?Obesity and infection. Another comorbidity?ДворецкийЛеонид ИвановичDvoretskiiLeonid I.

д.м.н., проф., заведующий кафедрой госпитальной терапии №2

MD, PhD, Professor, head of 2nd therapy department

dvoretski@mail.ru<p>ФГАОУ ВО &laquo;Первый Московский государственный медицинский университет им. И.М. Сеченова&raquo; Минздрава России</p>Россия<p>I.M. Sechenov First Moscow State Medical University (Sechenov University)</p>Russian Federation20191609201916238Copyright &#x00A9; Дворецкий Л.И., 20192019Дворецкий Л.И.Dvoretskii L.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/9745

Литературный обзор посвящен проблеме коморбидности ожирения (Ож) и инфекций. В настоящее время накоплен обширный материал о повышенной склонности больных Ож к различным инфекциям (респираторные, мочевые, вирусные, нозокомиальные, послеоперационные). Одним из патогенетических механизмов развития инфекций у больных Ож является дисфункция клеточного и гуморального иммунитета, индуцированная продукцией жировой тканью различных цитокинов (адипокинов), оказывающих иммуномодулирующий эффект в различных направлениях. Необходимы дальнейшие исследования в области эпидемиологии, механизмов развития и течения инфекций у больных с Ож, а также разработка тактики ведения данной категории пациентов (диагностика, антибактериальная терапия, предоперационная подготовка и др.).

A literature review is devoted to the problem of comorbidity of obesity (Ob) and infections. At present, extensive material has been accumulated about the increased propensity of patients with Ob to various infections (respiratory, urinary, viral, nosocomial, postoperative). One of the pathogenetic mechanisms of infection development in patients with Ob is dysfunction of cellular and humoral immunity, induced by adipose tissue production of cytokines (adipokines), which have an immunomodulating effect in various directions. Further research is needed in the field of epidemiology, mechanisms of development and course of infections in patients with Ob, as well as developing tactics for conducting this category of patients (diagnosis, antibiotic therapy, preoperative preparation, etc.).

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The authors declare that there are no conflicts of interest present.