References

ometendo

Ожирение и метаболизм

Obesity and metabolism

2071-87132306-5524

Endocrinology Research Centre

10.14341/omet9482

ometendo-9482

Research Article

Обзор литературы

Review

Ассоциации половых гормонов с компонентами инсулин-глюкозного гомеостаза

Associations of sex hormones with components of insulin-glucose homeostasis

https://orcid.org/0000-0003-0207-7063

Цыганкова

Оксана Васильевна

Tsygankova

Oksana V.

доктор медицинских наук, доцент кафедры неотложной терапиис эндокринологией и профпатологией

ScD, associate professor

oksana_c.nsk@mail.ru

https://orcid.org/0000-0001-9964-5463

Бадин

Артур Романович

Badin

Artur R.

клинический ординатор

resident

akherousin@mail.ru

https://orcid.org/0000-0002-4725-8565

Бондарева

Зоя Геннадьевна

Bondareva

Zoya G.

доктор медицинских наук, профессор кафедры неотложной терапии с эндокринологией и профпатологией

ScD, professor

zoya.bondareva.2017@mail.ru

https://orcid.org/0000-0002-4832-3197

Ложкина

Наталья Геннадьевна

Lozhkina

Natalya G.

доктор медицинских наук, доцент кафедры факультетской терапии

ScD, associate professor

lozhkina.n@mail.ru

https://orcid.org/0000-0003-0635-3571

Платонов

Дмитрий Юрьевич

Platonov

Dmitrii Y.

доктор медицинских наук, профессор кафедры госпитальной терапии и профессиональных болезней

ScD, professor

diplato64@mail.ru

ФГБОУ ВО Новосибирский государственный медицинский университет; НИИ терапии и профилактической медицины, филиал ФГБНУ «Федеральный исследовательский центр Институт цитологии и генетики Сибирского отделения Российской академии наук»РоссияNovosibirsk State Medical University; Research Institute of therapy and preventive medicine" branch of Federal Research Institute of a Cytology and GeneticsRussian Federation

ФГБОУ ВО Новосибирский государственный медицинский университетРоссияNovosibirsk State Medical UniversityRussian Federation

ФГБОУ ВО Тверской государственный медицинский университетРоссияTver State Medical UniversityRussian Federation

2018

28072018

152310

2018

Цыганкова О.В., Бадин А.Р., Бондарева З.Г., Ложкина Н.Г., Платонов Д.Ю.

Tsygankova O.V., Badin A.R., Bondareva Z.G., Lozhkina N.G., Platonov D.Y.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.omet-endojournals.ru/jour/article/view/9482

В данном литературном обзоре предпринята попытка анализа взаимосвязей основных половых гормонов с процессами развития и прогрессирования инсулинорезистентности как фундаментального патогенетического компонента инсулин-глюкозного гомеостаза. При оценке половых стероидов использовался комплексный подход – подробно описаны ассоциации как андрогенов, так и эстрогенов у лиц мужского и женского пола, большое внимание уделено нарушению секреции и эффективности основных адипоцитокинов – лептина и адипонектина в цепи взаимодействий половые гормоны – инсулин – глюкоза. В завершение обзора представлены новые данные об экспрессии натрий-зависимых котранспортеров глюкозы (SGLT) и глюкозных транспортеров (GLUT) у животных в зависимости от пола.

In this literature review, an attempt is made to analyze the interrelationships of the main sex hormones with the processes of development and progression of insulin resistance as a fundamental pathogenetic component of insulin-glucose homeostasis. In the evaluation of sex steroids, a complex approach was used - the associations of both androgens and estrogens in males and females are described in detail, a great deal of attention is paid to the violation of the secretion and effectiveness of the main adipocytokines - leptin and adiponectin in the sex hormone-insulin-glucose interaction chain. At the end of the review, new data on the expression of sodium-dependent glucose cotransporter (SGLT) and glucose transporters (GLUT) in animals, depending on sex, are presented.

обзоринсулинорезистентностьполэстрогеныандрогенылептинадипонектиннатрий-глюкозные котранспортеры

reviewinsulin resistancesexestrogensandrogensleptinadiponectinsodium-glucose transport proteins

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The authors declare that there are no conflicts of interest present.