References

ometendo

Ожирение и метаболизм

Obesity and metabolism

2071-87132306-5524

Endocrinology Research Centre

10.14341/omet9430

ometendo-9430

Research Article

Обзор литературы

Review

Адипокины: механизмы метаболических и поведенческих расстройств

Adipokines: mechanisms of metabolic and behavioral disorders

https://orcid.org/0000-0002-0755-8811

Chahirou

Yassine

departement sciences of life

yassine_chahirou@hotmail.fr

https://orcid.org/0000-0002-1028-7469

Mesfioui

Abdelhalim

a.mesfioui@yahoo.fr

https://orcid.org/0000-0001-9704-8526

Ouichou

Ali

ouichou@hotmail.com

https://orcid.org/0000-0003-4890-7069

Hessni

Aboubaker

elhessni70@yahoo.fr

<p>Университет имени Ибн Тофэйля</p>Марокко<p>Ibn Tofail University</p>Morocco

2018

23112018

1531420

2018

Chahirou Y., Mesfioui A., Ouichou A., Hessni A.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.omet-endojournals.ru/jour/article/view/9430

Текущие исследования показывают, что метаболические и поведенческие расстройства представляют собой существенную медицинскую проблему. Возникают вопросы о молекулярных причинах метаболических и поведенческих расстройств. В этом обзоре рассматривается взаимосвязь липидного обмена и потребления фруктозы, сопровождающаяся увеличением массы тела, а также сопутствующими расстройствами: гипертензией, инсулинорезистентностью, оксидативным стрессом и депрессией. Жировая ткань рассматривается как гормонпродуцирующая ткань с высокой секреторной активностью (метаболической и провоспалительной). Адипокины (гормоны жировой ткани) отвечают за регуляцию некоторых физиологических функций. В этом обзоре предпринята попытка разобраться как липогенез, приводящий к дислипидемии, воздействует на инсулинорезистентность, гипертензию, оксидативный стресс, депрессию, а также определить взаимосвязь между этими нарушениями.

Current studies show that metabolic and behavioral disorders represent severe health problems. Several questions arise about the molecular relationship of metabolic and behavioral disorders. This review will discuss the relationship of lipid metabolism and fructose consumption accompanied by an increase in weight as well as associated disorders: hypertension, insulin-resistance, oxidative stress and depression. Adipose tissue is considered as an endocrine tissue with intense secretory activities (metabolic and inflammatory). These adipokines are responsible for an alteration of several physiological functions. In this review we will try to understand how lipogenesis that causes dyslipidemia can influence insulin resistance, hypertension, oxidative stress, depression and the relationship between these various disorders.

депрессияфруктозагипертензияинсулинорезистентностьлипогенезлиполизокислительный стресс

depressionfructosehypertensioninsulin resistancelipogenesislipolysisoxidative stress

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The authors declare that there are no conflicts of interest present.