ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/omet201813-11ometendo-9362Research ArticleОбзор литературыReviewАналог глюкагоноподобного пептида-1 лираглутид (Саксенда®): механизм действия, эффективность в лечении ожиренияGglucagon-like peptide-1 analogue liraglutide (Saxenda®): mechanism of action, efficacy for the treatment of obesityhttps://orcid.org/0000-0003-3870-6394РоманцоваТатьяна ИвановнаRomantsovaTatiana I.

д.м.н., професор

Sc.D., professor

romantsovatatiana@rambler.ru<p>ФГАОУ ВО Первый Московский государственный медицинский университет имени И.М. Сеченова Минздрава России (Сеченовский Университет)</p>Россия<p>Sechenov First Moscow State Medical University</p>Russian Federation201825042018151311Copyright &#x00A9; Романцова Т.И., 20182018Романцова Т.И.Romantsova T.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/9362

Разработка эффективных методов лечения ожирения с целью профилактики множества ассоциированных заболеваний относится к числу приоритетных задач современных биомедицинских исследований. В 2016 г. в Российской Федерации для терапии ожирения зарегистрирован аналог глюкагоноподобного пептида-1 (ГПП-1) лираглутид 3 мг (Саксенда®). В обзоре представлены данные литературы о механизмах действия ГПП-1 и лираглутида на аппетит и массу тела. Проведен анализ эффективности и безопасности препарата Саксенда® на основании результатов основных клинических исследований.

The development of effective methods of obesity treatment with the goal of preventing many associated diseases is among the priorities of modern biomedical research. In 2016 glucagon-like peptide-1 analog (GLP-1) liraglutide 3 mg (Saxenda®) was approved in the Russian Federation for the treatment of obesity. This review presents literature data on the effects of GLP-1 and liraglutide on appetite and body weight as well as an analysis of the effectiveness and safety of drug Saxenda based on the results of major clinical trials.

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The authors declare that there are no conflicts of interest present.