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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ometendo</journal-id><journal-title-group><journal-title xml:lang="ru">Ожирение и метаболизм</journal-title><trans-title-group xml:lang="en"><trans-title>Obesity and metabolism</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2071-8713</issn><issn pub-type="epub">2306-5524</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/omet2017477-82</article-id><article-id custom-type="elpub" pub-id-type="custom">ometendo-8796</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Случай из практики</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Case Report</subject></subj-group></article-categories><title-group><article-title>Клинический случай сочетания несовершенного остеогенеза и болезни Грейвса</article-title><trans-title-group xml:lang="en"><trans-title>Osteogenesis imperfecta in combination with Graves disease</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0003-3785-0335</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шеремета</surname><given-names>Марина Сергеевна</given-names></name><name name-style="western" xml:lang="en"><surname>Sheremeta</surname><given-names>Marina S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук, зав отдлением</p></bio><bio xml:lang="en"><p>PhD</p></bio><email xlink:type="simple">marina888@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пигарова</surname><given-names>Екатерина Александровна</given-names></name><name name-style="western" xml:lang="en"><surname>Pigarova</surname><given-names>Ekaterina A.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук</p></bio><bio xml:lang="en"><p>PhD</p></bio><email xlink:type="simple">marina888@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Куликова</surname><given-names>Кристина Сергеевна</given-names></name><name name-style="western" xml:lang="en"><surname>Kulikova</surname><given-names>Kristina S.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук</p></bio><bio xml:lang="en"><p>PhD</p></bio><email xlink:type="simple">marina888@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Беловалова</surname><given-names>Ирина Михайловна</given-names></name><name name-style="western" xml:lang="en"><surname>Belovalova</surname><given-names>Irina M.</given-names></name></name-alternatives><bio xml:lang="ru"><p>кандидат медицинских наук</p></bio><bio xml:lang="en"><p>PhD</p></bio><email xlink:type="simple">belovalova.irina@endocrincentr.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тюльпаков</surname><given-names>Анатолий Николаевич</given-names></name><name name-style="western" xml:lang="en"><surname>Tyulpakov</surname><given-names>Anatoliy N.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук, профессор</p></bio><bio xml:lang="en"><p>ScD, Professor</p></bio><email xlink:type="simple">marina888@yandex.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><contrib-id contrib-id-type="orcid">https://orcid.org/0000-0002-7721-634X</contrib-id><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Румянцев</surname><given-names>Павел Олегович</given-names></name><name name-style="western" xml:lang="en"><surname>Rumiantsev</surname><given-names>Pavel O.</given-names></name></name-alternatives><bio xml:lang="ru"><p>доктор медицинских наук</p></bio><bio xml:lang="en"><p>ScD</p></bio><email xlink:type="simple">pavelrum@gmail.com</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff-alternatives id="aff-1"><aff xml:lang="ru"><institution>&lt;p&gt;ФГБУ &amp;laquo;Национальный медицинский исследовательский центр эндокринологии&amp;raquo; Минздрава России&lt;/p&gt;</institution><country>Россия</country></aff><aff xml:lang="en"><institution>&lt;p&gt;Endocrinology Research Centre&lt;/p&gt;</institution><country>Russian Federation</country></aff></aff-alternatives><pub-date pub-type="collection"><year>2017</year></pub-date><pub-date pub-type="epub"><day>27</day><month>12</month><year>2017</year></pub-date><volume>14</volume><issue>4</issue><fpage>77</fpage><lpage>82</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Шеремета М.С., Пигарова Е.А., Куликова К.С., Беловалова И.М., Тюльпаков А.Н., Румянцев П.О., 2017</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="ru">Шеремета М.С., Пигарова Е.А., Куликова К.С., Беловалова И.М., Тюльпаков А.Н., Румянцев П.О.</copyright-holder><copyright-holder xml:lang="en">Sheremeta M.S., Pigarova E.A., Kulikova K.S., Belovalova I.M., Tyulpakov A.N., Rumiantsev P.O.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.omet-endojournals.ru/jour/article/view/8796">https://www.omet-endojournals.ru/jour/article/view/8796</self-uri><abstract><p>Несовершенный остеогенез (НО) – это группа генетически обусловленных заболеваний, в основе которых лежит нарушение формирования костной ткани. В свою очередь, избыток тиреоидных гормонов при болезни Грейвса (БГ) оказывает негативное влияние на костную ткань, тем самым усугубляя течение НО, что требует от эндокринолога максимально внимательного ведения пациентов с сочетанием данных патологий. В настоящей статье представлен уникальный клинический случай сочетания БГ и НО.</p></abstract><trans-abstract xml:lang="en"><p>Osteogenesis imperfecta (OI) – is a group of genetically disorders, which are charaterized by a disturbed bone formation. In turn, the excess of thyroid hormones in Graves' disease (GD) also posses a negative effect on bone tissue, thereby aggravating OI. That requires from the endocrinologist the most careful management of patients with the combination of these pathologies. In this article, we present a unique clinical case of a combination of GD and OI.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>болезнь Грейвса</kwd><kwd>несовершенный остеогенез</kwd><kwd>клинический случай</kwd></kwd-group><kwd-group xml:lang="en"><kwd>Graves disease</kwd><kwd>osteogenesis imperfecta</kwd><kwd>clinical case</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Bassett JHD, Williams GR. Role of Thyroid Hormones in Skeletal Development and Bone Maintenance. Endocr Rev. 2016;37(2):135-187. doi: 10.1210/er.2015-1106.</mixed-citation><mixed-citation xml:lang="en">Bassett JHD, Williams GR. Role of Thyroid Hormones in Skeletal Development and Bone Maintenance. 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