References

ometendo

Ожирение и метаболизм

Obesity and metabolism

2071-87132306-5524

Endocrinology Research Centre

10.14341/omet2017117-23

ometendo-8761

Research Article

Обзор литературы

Review

Препараты для лечения центрального несахарного диабета: историческая справка и современные возможности

Drugs for the treatment of central diabetes insipidus: historical background and modern opportunities

Михайлова

Дарья Сергеевна

Mikhaylova

Dar'ya S.

клинический аспирант

postgraduate student

d.s.mikhaylova@mail.ru

Пигарова

Екатерина Александровна

Pigarova

Ekaterina A.

к.м.н.

PhD

kpigarova@gmail.com

Дзеранова

Лариса Константиновна

Dzeranova

Larisa K.

д.м.н.

ScD

dzeranovalk@yandex.ru

<p>ФГБУ "Эндокринологический научный центр" Минздрава России</p>Россия<p>Endocrinology Research Centre</p>Russian Federation

2017

13062017

1411723

2017

Михайлова Д.С., Пигарова Е.А., Дзеранова Л.К.

Mikhaylova D.S., Pigarova E.A., Dzeranova L.K.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.omet-endojournals.ru/jour/article/view/8761

Центральный несахарный диабет – тяжелое заболевание, характеризующееся уменьшением секреции аргинин-вазопрессина и приводящее в результате к выделению неадекватно большого количества гипотоничной мочи. Основным клиническим проявлением заболевания является синдром полиурии-полидипсии, существенно нарушающий качество жизни пациентов. В настоящее время для лечения заболевания применяются препараты десмопрессина, синтетического аналога аргинин-вазопрессина, доступные в виде таблетированных форм и интраназальных спреев. Выбор наиболее удобной формы препарата является обязательным условием успешной терапии заболевания.

Central diabetes insipidus is a severe disease with disturbance of arginine vasopressin secretion, which leads to excretion of large amounts of hypotonic urine. The polyuria-polydipsia syndrome is essential as a clinical presentation and high impact condition. Desmopressin, a synthetic analog of arginine vasopressin, is used to compensate a water-electrolyte balance is available in forms of tablets and intranasal spray. Free drug choice is obligated for proper treatment.

центральный несахарный диабетдесмопрессин

diabetes insipidusdesmopressin

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The authors declare that there are no conflicts of interest present.