ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/omet2018112-18ometendo-8720Research ArticleОбзор литературыReviewНеклассические эффекты витамина DNon-classical effects of vitamin Dhttps://orcid.org/0000-0001-8817-1901ЕгшатянЛилит ВаниковнаEgshatyanLilit V.

к.м.н., старший научный сотрудник центра патологии околощитовидных желез ЭНЦ, ассистент кафедры эндокринологии и диабетологии МГМСУ

PhD

lilit.egshatyan@yandex.ru<p>ФГБУ "Национальный медицинский исследовательский центр эндокринологии" Минздрава России;&nbsp;ГБОУ ВО &laquo;Московский государственный медико-стоматологический университет им. А.И. Евдокимова&raquo;</p>Россия<p>Endocrinology Research Centre;&nbsp;A.I. Evdokimov Moscow State University of Medicine and Dentistry</p>Russian Federation2018250420181511218Copyright &#x00A9; Егшатян Л.В., 20182018Егшатян Л.В.Egshatyan L.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/8720

Существуют данные об участии витамина D в модуляции воспалительной реакции и развитии сахарного диабета. Поскольку активация провоспалительных биомаркеров и цитокинов препятствует нормальному обмену веществ и нарушает синтез инсулина и чувствительность тканей к нему, предполагается, что витамин D может влиять на гомеостаз липидов и глюкозы путем модуляции воспалительной реакции и ренин-ангиотензиновой системы. В статье представлен обзор литературы, обобщающий данные о механизмах влияния дефицита витамина D на метаболические нарушения.

Some studies support the involvement of vitamin D in modulating the inflammatory response and developing diabetes. Since the activation of inflammatory biomarkers, cytokines and pathways interferes with normal metabolism and disrupts proper insulin signaling and insulin resistance, it is hypothesized that vitamin D could influence lipid and glucose homeostasis by modulating inflammatory response and renin-angiotensin system. In this review discussed the mechanisms of the influence of vitamin D on metabolic disease.

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The authors declare that there are no conflicts of interest present.