ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/omet201723-8ometendo-8250Research ArticleОбзор литературыReviewРаспределение жировых отложений: разгадка кажущегося парадокса ожирения в кардиологии?Body fat distribution: the answer to the apparent paradox of obesity in cardiology?БородкинаДарья АндреевнаBorodkinaDaria A.

врач-эндокринолог областного центра диабетологии

MD

alpheia@mail.ruГруздеваОльга ВиктровнаGruzdevaOlga V.

д.м.н., зав. лабораторией  исследования  гомеостаза отдела  диагностики сердечно-сосудистых заболеваний

ScD

o_gruzdeva@mail.ruКвитковаЛюдмила ВладимировнаKvitkovaLudmila V.

д.м.н., профессор, зав. кафедрой факультетской терапии, эндокринологии и  профпатологии

ScD, prof.

kvitkova_lv@mail.ruБарбарашОльга ЛеонидовнаBarbarashOlga L.

д.м.н. профессор, директор ФГБНУ «Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний», Зав. кафедрой кардиологии и сердечно – сосудистой хирургии ФГБОУ ВО «Кемеровский государственный медицинский университет»

ScD, prof.

olb61@mail.ru<p>ФГБНУ &laquo;Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний&raquo;; ГАУЗ КО &laquo;Кемеровская областная клиническая больница&raquo; имени С.В. Беляева.</p>Россия<p>Institution Research Institute for Complex Issues of Cardiovascular Diseases; "Kemerovo regional clinical hospital"</p>Russian Federation<p>ФГБНУ &laquo;Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний&raquo;;&nbsp;ФГБОУ ВО &laquo;Кемеровский государственный медицинский университет&raquo; Минздрава России</p>Россия<p>Institution Research Institute for Complex Issues of Cardiovascular Diseases;&nbsp;Kemerovo State Medical University</p>Russian Federation<p>ФГБОУ ВО &laquo;Кемеровский государственный медицинский университет&raquo; Минздрава России</p>Россия<p>Kemerovo State Medical University</p>Russian Federation<p>ФГБНУ &laquo;Научно-исследовательский институт комплексных проблем сердечно-сосудистых заболеваний&raquo;; ФГБОУ ВО &laquo;Кемеровский государственный медицинский университет&raquo; Минздрава России</p>Россия<p>Institution Research Institute for Complex Issues of Cardiovascular Diseases; Kemerovo State Medical University</p>Russian Federation20171509201714238Copyright &#x00A9; Бородкина Д.А., Груздева О.В., Квиткова Л.В., Барбараш О.Л., 20172017Бородкина Д.А., Груздева О.В., Квиткова Л.В., Барбараш О.Л.Borodkina D.A., Gruzdeva O.V., Kvitkova L.V., Barbarash O.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/8250

На сегодняшний день, несмотря на все предпринимаемые меры, сердечно-сосудистые заболевания остаются основной причиной временной утраты трудоспособности, инвалидизации и смертности. Ожирение является основным фактором риска развития сердечно-сосудистых заболеваний и осложнений от них. Тем не менее, не все жировые депо обладают одинаковой провоспалительной, паракринной и метаболической активностью. Недавние исследования показали, что накопление именно висцерального жира, а не подкожного связано с повышением кардиометаболического риска. В то же время есть данные, что увеличение площади висцерального жира является защитным механизмом против липотоксичности. Целью данного обзора является обсуждение данных современной литературы, отражающих особенности висцерального, эпикардиального и периваскулярного жирового депо, а также их ассоциации с сердечно-сосудистыми заболеваниями.

Today, despite all the measures taken, cardiovascular diseases remain the main cause of temporary invalidization, disability and mortality. Obesity is a major risk factor of cardiovascular diseases and complications from them. However, not all fat depots have the same proinflammatory, paracrine and metabolic activity. Recent studies have shown that the accumulation of visceral fat, and not subcutaneous fat, is associated with an increase in cardiometabolic risk. At the same time, there is evidence that an increase in the area of visceral fat is a protective mechanism against lipotoxicity. The purpose of this review is to discuss current literature data reflecting the characteristics of the visceral, epicardial and perivascular fat depots, and also their association with cardiovascular diseases.

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The authors declare that there are no conflicts of interest present.