ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/omet201719-16ometendo-8220Research ArticleОбзор литературыReviewМетаболические нарушения при адипоцитокиновом дисбалансе и гестационные осложненияMetabolic disorders in adipocytokine imbalance and gestational complicationshttps://orcid.org/0000-0003-3173-021XЧабановаНаталья БорисовнаChabanovaNatalya B.

к.м.н., доцент кафедры акушерства и гинекологии

PhD, associate Professor at  Obstetrics and gynecology department

Natalya.Chabanova@gmail.comМатаевСергей ИвановичMataevSergey I.

д.м.н., профессор

ScD, Professor

mataevci@rambler.ruВасильковаТатьяна НиколаевнаVasilkovaTatiana N.

д.м.н., профессор кафедры госпитальной терапии с курсом эндокринологии и фтизиатрии

ScD, Professor at Department of hospital therapy with course of Endocrinology  and Phthisiology

vasilkovatn@rambler.ruТрошинаИрина АлександровнаTroshinaIrina A.

ScD, Professor at Department of hospital therapy with course of Endocrinology  and Phthisiology

troshina@tyumsmu.ru<p>ФГБОУ ВО Тюменский государственный медицинский университет Министерства здравоохранения Российской Федерации</p>Россия<p>Tyumen State Medical University</p>Russian Federation<p>ООО Многопрофильный медицинский центр &laquo;Лимфомед&raquo;</p>Россия<p>Мultiprofile medical center &laquo;Limfomed&raquo;</p>Russian Federation201713062017141916Copyright &#x00A9; Чабанова Н.Б., Матаев С.И., Василькова Т.Н., Трошина И.А., 20172017Чабанова Н.Б., Матаев С.И., Василькова Т.Н., Трошина И.А.Chabanova N.B., Mataev S.I., Vasilkova T.N., Troshina I.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/8220

Жировая ткань, являясь эндокринным органом, синтезирует большое количество биологически активных веществ, адипоцитокинов, которые обладают как местным, так и системным действием, оказывая влияние на сосудистую стенку, чувствительность тканей к инсулину, метаболизм глюкозы, системное воспаление. Данные клинических и экспериментальных исследований доказывают тесную связь между дисбалансом адипоцитокинов и такими осложнениями беременности, как инсулинорезистентность, гестационный сахарный диабет, преэклампсия. В связи с этим пристальное внимание акушеров-гинекологов и эндокринологов направлено на этиопатогенетические аспекты формирования гестационных осложнений при метаболических нарушениях, вызванных дисбалансом адипоцитокинов при материнском ожирении, и поиск маркеров этих нарушений. В обзоре представлены современные данные литературы о гормонах жировой ткани и их влиянии на течение гестационного процесса.

Adipose tissue as an endocrine organ synthesizes a large number of biologically active substances, adipocytokines, which have both local and systemic effects influencing the vascular wall, tissue sensitivity to insulin, glucose metabolism, and systemic inflammation. The data obtained from clinical and experimental studies demonstrate the close relationship between the imbalance of adipocytokines and pregnancy complications such as insulin resistance, gestational diabetes, and preeclampsia. In this connection, close attention of obstetrician-gynecologists and endocrinologists is focused on etiopathogenic aspects of the formation of gestational complications with metabolic disorders caused by an imbalance of adipocytokines with maternal obesity and to the search for markers of these disorders. The review presents the current literature data on adipose tissue hormones and their influence on the course of a gestational process.

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The authors declare that there are no conflicts of interest present.