ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/omet2016415-20ometendo-8202Research ArticleНаучные исследованияOriginal studiesАнализ информативности определения мелатонина при синдроме поликистозных яичниковAnalysis of the informativeness of melatonin evaluation in polycystic ovary syndromeАндрееваЕлена НиколаевнаAndreevaElenaд.м.н., проф.endogin@mail.ruАбсатароваЮлия СергеевнаAbsatarovaYulia

научный сотрудник

research associate

korsil2008@yandex.ruШереметьеваЕкатерина ВикторовнаSheremetyevaEkaterina

к.м.н.

PhD

s1981k@yandex.ruДеркачДмитрий АнатольевичDerkatchDmitriy

врач

dmitriy.derkatch@gmail.comПономареваТатьяна АлексеевнаPonomarevaTatiana

врач

MD

ponomareva911@mail.ruТюльпаковАнатолий НиколаевичTiulpakovAnatoly

д.м.н., проф.

anatolytiulpakov@gmail.comИоутсиВиталий АлексеевичIoutsiVitaliy

к.м.н.

PhD

vitalik_org@mail.ruИльинАлександр ВикторовичIlyinAlexander

врач

MD

alexandrilyin@bk.ruМурватовКамолжон ДжамолхоновичMurvatovKamoljon

к.м.н.

Phd

mkamol@mail.ruФГБУ «Эндокринологический научный центр» Минздрава России ГБОУ ВПО «Московский государственный медико-стоматологический университет им. А. И. Евдокимова» Минздрава РФРоссияEndocrinology Research CentreRussian FederationФГБУ «Эндокринологический научный центр» Минздрава РоссииРоссияEndocrinology Research CentreRussian FederationГБОУ ВПО «Московский государственный медико-стоматологический университет им. А. И. Евдокимова» Минздрава РФ Главный военный клинический госпиталь ВВ МВД РФРоссияMain Military Clinical Hospital MVD Russian FederationRussian Federation2016291220161341520Copyright © Андреева Е.Н., Абсатарова Ю.С., Шереметьева Е.В., Деркач Д.А., Пономарева Т.А., Тюльпаков А.Н., Иоутси В.А., Ильин А.В., Мурватов К.Д., 20162016Андреева Е.Н., Абсатарова Ю.С., Шереметьева Е.В., Деркач Д.А., Пономарева Т.А., Тюльпаков А.Н., Иоутси В.А., Ильин А.В., Мурватов К.Д.Andreeva E., Absatarova Y., Sheremetyeva E., Derkatch D., Ponomareva T., Tiulpakov A., Ioutsi V., Ilyin A., Murvatov K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/8202Введение

Введение. Синдром поликистозных яичников (СПЯ) – одна из наиболее распространенных эндокринных патологий среди женщин репродуктивного возраста. В последнее время среди ученых идет обсуждение роли мелатонина в патогенезе данного синдрома, т.к есть доказательства его влияния на репродуктивную функцию и созревание яйцеклеток.

Цель

Цель. Изучить информативность определения мелатонина и его связь с сомнологическими нарушениями при СПЯ.

Методы

Методы. В исследовании участвовали 120 женщин в возрасте 17–35 лет: 60 пациенток с СПЯ и 60 женщин группы контроля. У участниц исследования проводился анализ уровня мелатонина в крови, в слюне и его метаболита в моче – 6-сульфатоксимелатонина. Для выявления расстройств сна было проведено анкетирование с помощью опросника балльной оценки субъективных характеристик сна.

Результаты

Результаты. На основании анкеты балльной оценки субъективных характеристик сна в группе СПЯ были выявлены расстройства сна (до 70% больных) независимо от индекса массы тела. У пациенток с СПЯ по сравнению с группой контроля были достоверно выше уровень 6-сульфатоксимелатонина в моче, ночной уровень мелатонина в слюне (03.00) и мелатонина в крови независимо от индекса массы тела. При этом уровень мелатонина в фолликулярной жидкости был ниже у пациенток с СПЯ. Была обнаружена достоверная корреляция уровня мелатонина в крови и степени нарушения сна по данным анкеты балльной оценки субъективных характеристик сна, уровня мелатонина в слюне в 03.00 и уровня 6-сульфатоксимелатонина в суточной моче (р=0,046).

Заключение

Заключение. СПЯ – полиэтиологичное заболевание, немаловажную роль в формировании и прогрессировании которого играет мелатонин. Взаимосвязь уровней этого гормона в различных биологических жидкостях организма говорит о его системном действии и непосредственном участии в регуляции репродуктивной функции женщин.

 

 

 

 

Background

Background. Polycystic ovary syndrome (PCOS) is one of the most common endocrine disorders in women of reproductive age. Recently, the role of melatonin in the pathogenesis of this syndrome became widely discussed among the scientists, because there is an evidence of its impact on the reproductive function and maturation of oocytes.

Aim

Aim. To study a informativeness of melatonin determination and its relationship with sleep disorders in PCOS.

Materials and methods

Materials and methods. The study involved 120 women aged 17–35 years: 60 patients with PCOS and 60 women without this disorder as controls. The level of melatonin in the blood, saliva and its metabolite in urine – 6 sulfatoximelatonin were analyzed. To identify sleep disorders survey was conducted using a questionnaire scoring subjective sleep characteristics.

Results

Results. Sleep disorders based on subjective scoring profiles sleep characteristics were identified in PCOS group (up to 70% of patients) regardless of BMI. The level of 6-sulfatoximelatonin in urine, nocturnal melatonin levels in saliva (at 3:00 AM) and melatonin in the blood were significantly higher in patients with PCOS compared with the control group regardless of BMI. The level of melatonin in follicular fluid was lower in patients with PCOS. There was a significant correlation of melatonin levels in the blood and the degree of sleep disorders according to the questionnaire scoring subjective sleep characteristics, the level of melatonin in saliva at 3:00 AM and a 6-sulfatoximelatonin in daily urine (p = 0.046).

Conclusions

Conclusions. PCOS is polyetiology disease, and an important role in the formation and progression in which plays melatonin. Correlation of levels of this hormone in different body fluids suggests its systemic action and direct involvement in the regulation of reproductive function.

 

 

 

 

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The authors declare that there are no conflicts of interest present.