ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/omet2015234-38ometendo-7222Research ArticleЛекцияLectureОжирение и неалкогольная жировая болезнь печени: метаболические риски и их коррекцияObesity and nonalcoholic fatty liver disease: metabolic risks and their correctionКомшиловаКсения АндреевнаKomshilovaKseniya Andreevna

научный сотрудник отделения терапии с группой ожирения

kom-ksusha@rambler.ruТрошинаЕкатерина АнатолевнаTroshinaEkaterina Anatol'evna

д.м.н., профессор, зав. отделением терапии с группой ожирения

troshina@inbox.ruФГБУ "Эндокринологический научный центр" Минздрава РоссииРоссияEndocrinology Research CentreRussian Federation2015270620151223539Copyright © Комшилова К.А., Трошина Е.А., 20152015Комшилова К.А., Трошина Е.А.Komshilova K.A., Troshina E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/7222

Неалкогольная жировая болезнь печени (НАЖБП) – это распространенное хроническое заболевание печени, основным признаком которого является накопление жира в гепатоцитах, не связанное со злоупотреблением алкоголем. НАЖБП ассоциирована с ожирением, особенно абдоминальным, метаболическим синдромом и различными метаболическими маркерами риска развития сердечно-сосудистых заболеваний и сахарного диабета 2 типа (СД2), что отражается на заболеваемости, прогнозе и продолжительности жизни больных ожирением. В данной лекции изложены основные причины заболевания, его патогенез, клиническая картина, диагностика и лечение.

Nonalcoholic fatty liver disease (NAFLD) – a common chronic disease of the liver, the main feature of which is the accumulation of fat in hepatocytes, is not related to alcohol abuse. NAFLD is associated with obesity, especially abdominal, metabolic syndrome and various metabolic markers of risk for cardiovascular disease and type 2 diabetes, which affects the incidence, prognosis and life expectancy of patients with obesity. This lecture describes the main causes of the disease, its pathogenesis, clinical presentation, diagnosis and treatment.

ожирениенеалкогольная жировая болезнь печениинсулинорезистентность.obesitynonalcoholic fatty liver diseaseinsulin resistanceReferencesLazo M, Clark JM, editors. The epidemiology of nonalcoholic fatty liver disease: a global perspective. Seminars in liver disease; 2008; 28(4): Р. 339-50.Lazo M, Clark JM, editors. The epidemiology of nonalcoholic fatty liver disease: a global perspective. Seminars in liver disease; 2008; 28(4): Р. 339-50.Musso G, Gambino R, Cassader M. Non‐alcoholic fatty liver disease from pathogenesis to management: an update. Obesity Reviews. 2010;11(6):430-45.Musso G, Gambino R, Cassader M. Non‐alcoholic fatty liver disease from pathogenesis to management: an update. Obesity Reviews. 2010;11(6):430-45.Буеверов А.О. Хронические заболевания печени. Краткое руководство для практикующих врачей. – М.: "МИА"; 2013. [Bueverov AO. Khronicheskie zabolevaniya pecheni. Kratkoe rukovodstvo dlya praktikuyushchikh vrachey. Moscow: "MIA"; 2013. (In Russ).]Буеверов А.О. Хронические заболевания печени. Краткое руководство для практикующих врачей. – М.: "МИА"; 2013. [Bueverov AO. Khronicheskie zabolevaniya pecheni. Kratkoe rukovodstvo dlya praktikuyushchikh vrachey. Moscow: "MIA"; 2013. (In Russ).]Dowman JK, Tomlinson J, Newsome P. Pathogenesis of non-alcoholic fatty liver disease. Qjm. 2010;103(2):71-83.Dowman JK, Tomlinson J, Newsome P. Pathogenesis of non-alcoholic fatty liver disease. Qjm. 2010;103(2):71-83.Targher G, Day CP, Bonora E. Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. New England Journal of Medicine. 2010;363(14):1341-50.Targher G, Day CP, Bonora E. Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. New England Journal of Medicine. 2010;363(14):1341-50.Lau E, Carvalho D, Freitas P. Gut Microbiota: Association with NAFLD and Metabolic Disturbances. BioMed Research International. 2015. doi:10.1155/2015/979515Lau E, Carvalho D, Freitas P. Gut Microbiota: Association with NAFLD and Metabolic Disturbances. BioMed Research International. 2015. doi:10.1155/2015/979515Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, Cusi K, et al. The diagnosis and management of non‐alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology. 2012;55(6):2005-23. doi:10.1002/hep.25762Chalasani N, Younossi Z, Lavine JE, Diehl AM, Brunt EM, Cusi K, et al. The diagnosis and management of non‐alcoholic fatty liver disease: Practice Guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association. Hepatology. 2012;55(6):2005-23. doi:10.1002/hep.25762Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology. 2005;41(6):1313-21. doi:10.1002/hep.20701Kleiner DE, Brunt EM, Van Natta M, Behling C, Contos MJ, Cummings OW, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology. 2005;41(6):1313-21. doi:10.1002/hep.20701Adams L, Angulo P. Treatment of non-alcoholic fatty liver disease. Postgraduate medical journal. 2006;82(967):315-22. doi:10.1136/pgmj.2005.042200Adams L, Angulo P. Treatment of non-alcoholic fatty liver disease. Postgraduate medical journal. 2006;82(967):315-22. doi:10.1136/pgmj.2005.042200Marchesini G, Bianchi G, Tomassetti S, Zoli M, Melchionda N. Metformin in nonalcoholic steatohepatitis. The Lancet. 2001;358(9285):893-4. doi:10.1016/S0140-6736(01)06042-1Marchesini G, Bianchi G, Tomassetti S, Zoli M, Melchionda N. Metformin in nonalcoholic steatohepatitis. The Lancet. 2001;358(9285):893-4. doi:10.1016/S0140-6736(01)06042-1Nair S, Diehl A, Wiseman M, Farr G, Perrillo R. Metformin in the treatment of non‐alcoholic steatohepatitis: a pilot open label trial. Alimentary pharmacology & therapeutics. 2004;20(1):23-8.Nair S, Diehl A, Wiseman M, Farr G, Perrillo R. Metformin in the treatment of non‐alcoholic steatohepatitis: a pilot open label trial. Alimentary pharmacology & therapeutics. 2004;20(1):23-8.Vernon G, Baranova A, Younossi ZM. Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Alimentary Pharmacology & Therapeutics. 2011;34(3):274-85. PMID:21623852 doi: 10.1111/j.1365-2036.2011.04724.xVernon G, Baranova A, Younossi ZM. Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults. Alimentary Pharmacology & Therapeutics. 2011;34(3):274-85. PMID:21623852 doi: 10.1111/j.1365-2036.2011.04724.x

The authors declare that there are no conflicts of interest present.