ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/omet2015116-19ometendo-7018Research ArticleНаучные исследованияOriginal studiesГлюкозозависимый инсулинотропный полипептид – новое звено в развитии ожиренияGlucose-dependent insulinotropic polypeptide - a new link in the development of obesityШестаковаЕкатерина АлексеевнаShestakovaEkaterina Alekseevna

к.м.н., научный сотрудник отделения интервенционной кардиологии

PhD, researcher at the Interventional Cardiology Department

katiashestakova@mail.ruИльинАлександр ВикторовичIl'inAleksandr Victorovich

заведующий лабораторией

Head of the Laboratory

alexilin2005@yandex.ruШестаковаМарина ВладимировнаShestakovaMarina Vladimirovna

д.м.н. проф., член-корр. РАН, директор  Института диабета. Зав. кафедры эндокринологии и диабетологии педиатрического факультета Первого МГМУ им. И.М. Сеченова Минздрава России Москва

MD, PhD. professor., corresponding member of  Russian Academy of Sciences, Director of Institute of Diabetes  Head of the Endocrinology and Diabetology Department at Pediatric Faculty of The First Sechenov Moscow State Medical University

katiashestakova@mail.ruДедовИван ИвановичDedovIvan Ivanovich

академик РАН, директор

libr@endocrincentr.ruФГБУ «Эндокринологический научный центр» Минздрава РоссииРоссияEndocrinology Research CentreRussian Federation2015100220151211619Copyright © Шестакова Е.А., Ильин А.В., Шестакова М.В., Дедов И.И., 20152015Шестакова Е.А., Ильин А.В., Шестакова М.В., Дедов И.И.Shestakova E.A., Il'in A.V., Shestakova M.V., Dedov I.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/7018Актуальность

Актуальность. Глюкозозависимый инсулинотропный полипептид (ГИП) наряду с глюкагоноподобным пептидом -1 (ГПП-1) является интестинальным инкретиновым гормоном, стимулирующим секрецию инсулина в ответ на прием пищи. В последние годы активно обсуждается возможное участие ГИП в развитии ожирения.

Цель

Цель. Целью настоящего исследования была оценка стимулированной секреции гормонов инкретинового ряда (ГИП и ГПП-1) у лиц с факторами риска сахарного диабета 2 типа (СД 2) и различным индексом массы тела (ИМТ).

Материалы и методы

Материалы и методы. Оценка секреции ГИП и ГПП-1 в ходе перорального глюкозотолерантного теста с 75 г глюкозы (исходно, на 30 и 120 минутах) проведена у 127 пациентов с факторами риска СД 2.

Результаты

Результаты. В исследовании отмечались достоверно значимо более высокие уровни ГИП в группе пациентов с ИМТ≥ 35 кг/м2 по сравнению с лицами с меньшим ИМТ как натощак, так и в ходе нагрузки. Аналогично стимулированная секреция ГИП была достоверно выше у лиц с наличием инсулинорезистентности (определенной по показателю HOMA-IR) по сравнению с лицами без таковой. Отличия в стимулированной секреции ГПП-1 в группах лиц с различным ИМТ не были достоверными.

Заключение

Заключение. Полученная в нашем исследовании взаимосвязь ГИП со степенью ожирения позволяет предположить участие этого гормона в регуляции жирового обмена.

Objective

Objective. Glucose-dependent insulinotropic polypeptide (GIP) as well as glucagon-like peptide-1 (GLP-1) is intestinal incretin hormone that stimulates insulin secretion in response to feeding. Much evidence of GIP contribution to obesity development has been found recently.

Aim

Aim. The aim of the study was to evaluate glucose-stimulated GIP and GLP-1 secretion in people with type 2 diabetes (T2D) risk factors and different body mass index (BMI).

Materials and methods

Materials and methods. Total GIP and GLP-1 secretion was estimated in 127 patients with T2D risk factors during OGTT (75 g glucose) on 0, 30 and 120 minutes.

Results

Results. Patients with BMI≥ 35 kg/m2 had significantly higher fasting and stimulated GIP levels than participants with less BMI. GIP secretion was also higher in patients was insulinresistance, estimated by HOMA-IR, comparing to non-insulinresistant patients. Difference in GLP-1 secretion in patients within several BMI groups was nonsignificant.

Conclusion

Conclusion. Our results suggest GIP is related to obesity degree, that means it can play a role in lipid metabolism and obesity development. 

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The authors declare that there are no conflicts of interest present.