References

ometendo

Ожирение и метаболизм

Obesity and metabolism

2071-87132306-5524

Endocrinology Research Centre

10.14341/omet201415-18

ometendo-6654

Research Article

Статьи

Articles

Репродукция и энергетический баланс: интегративная роль пролактина

Reproduction and energy balance: the integrative role of prolactin

Romantsova

T I

д.м.н., профессор кафедры эндокринологии; ГБОУ ВПО Первый МГМУ имени И.М.Сеченова МЗ РФ

romantsovatatiana@rambler.ru

2014

15032014

111

№1 (2014)

518

2014

Romantsova T.I.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.omet-endojournals.ru/jour/article/view/6654

Физиологические механизмы, координирующие репродукцию, тесно связаны с регуляцией энергетического баланса. За последние годы накопилось множество данных, свидетельствующих о том, что помимо влияния на молочные железы, пролактин участвует в регуляции метаболизма. Гиперпролактинемия ассоциирована с ожирением, лечение агонистами дофамина способствует снижению массы тела. В данном обзоре обсуждается роль пролактина в интеграции метаболического контроля и репродуктивной функции, вклад гормона в развитие ожирения, а также влияние терапии каберголином на массу тела и другие факторы риска сердечно-сосудистых заболеваний.

The physiological mechanisms controlling reproduction are closely linked to energy balance. In the recent years, accumulating evidence suggests that prolactin regulates metabolic functions, besides regulating breast development and stimulating milk formation. Hyperprolactinemia is associated with obesity and treatment with dopamine agonists results in weight loss. We discuss the integrated effects of prolactin in the metabolic control and reproductive function, the role of prolactin in the pathogenesis of obesity. The present review also describes the effects of treatment with cabergoline on body weight and cardiovascular risk markers.

пролактинрепродукцияэнергетический балансожирениекаберголин

prolactinreproductionenergy balanceobesitycabergoline

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The authors declare that there are no conflicts of interest present.