ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/omet2014351-55ometendo-6651Research ArticleСлучай из практикиCase ReportПервичный гиперпаратиреоз в сочетании с метаболическим синдромом и синдромом апноэ во сне.Primary hyperparathyroidism in combination with metabolic syndrome and sleep apneaShvangiradzeTeona Albertovna

клинический аспирант

teona.endo@gmail.comBurchakovDenis Igorevich

клинический аспирант

eversmith.msk@gmail.comDzeranovaLarisa Konstantinovna

д.м.н., главный научный сотрудник отделения нейроэндокринологии и остеопатий

dzeranovalk@yandex.ruKimIlya Victorovich

к.м.н., врач-хирург отдела хирургии эндокринных органов

ilyakim@yandex.ruKuznetsovSergey Nikolaevich

врач-хирург отдела хирургии эндокринных органов

kuznetsov_enc@mail.ruSoldatovaTatyana Vasil'evna

к.м.н., зав. отделением ультразвуковой диагностики

teona.endo@gmail.comMokryshevaNatal'ya Nikolaevna

д.м.н., ведущий научный сотрудник отделения нейроэндокринологии и остеопатий

nm70@mail.ruPigarovaEkaterina Aleksandrovnakpigarova@gmail.comФГБУ Эндокринологический научный центр Минздрава РоссииРоссияEndocrinology Research Centre, MoscowRussian Federation2014290620141135155Copyright © Shvangiradze T.A., Burchakov D.I., Dzeranova L.K., Kim I.V., Kuznetsov S.N., Soldatova T.V., Mokrysheva N.N., Pigarova E.A., 20142014Shvangiradze T.A., Burchakov D.I., Dzeranova L.K., Kim I.V., Kuznetsov S.N., Soldatova T.V., Mokrysheva N.N., Pigarova E.A.Shvangiradze T.A., Burchakov D.I., Dzeranova L.K., Kim I.V., Kuznetsov S.N., Soldatova T.V., Mokrysheva N.N., Pigarova E.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/6651слова: первичный гиперпаратиреозожирениеапноэ во снеprimary hyperparathyroidismobesitysleep apneaReferencesAdami S, Marcocci C, Gatti D. Epidemiology of primary hyperparathyroidism in Europe. J Bone Miner Res 2002;17 Suppl 2(2):18-23. PMID: 12412773.Adami S, Marcocci C, Gatti D. Epidemiology of primary hyperparathyroidism in Europe. J Bone Miner Res 2002;17 Suppl 2(2):18-23. PMID: 12412773.Bilezikian JP, Silverberg SJ. Asymptomatic Primary Hyperparathyroidism. N Engl J Med 2004 Апр;350(17):1746-1751. doi: 10.1056/NEJMcp032200.Bilezikian JP, Silverberg SJ. Asymptomatic Primary Hyperparathyroidism. N Engl J Med 2004 Апр;350(17):1746-1751. doi: 10.1056/NEJMcp032200.Garcia de la Torre, N . Parathyroid adenomas and cardiovascular risk. Endocrine Related Cancer 2003;10(2):309-322. doi: 10.1677/erc.0.0100309.Garcia de la Torre, N . Parathyroid adenomas and cardiovascular risk. Endocrine Related Cancer 2003;10(2):309-322. doi: 10.1677/erc.0.0100309.Мокрышева Н. Г. Первичный гиперпаратиреоз (эпидемиология, клиника, современные принципы диагностики и лечения): дис. – М, 2011. [Mokrysheva N.G. Pervichnyy giperparatireoz (Epidemiologiya, klinika, sovremennye printsipy diagnostiki i lecheniya) [Dissertation]. Moscow: Endocrinology Research Centre; 2011.]Мокрышева Н. Г. Первичный гиперпаратиреоз (эпидемиология, клиника, современные принципы диагностики и лечения): дис. – М, 2011. [Mokrysheva N.G. Pervichnyy giperparatireoz (Epidemiologiya, klinika, sovremennye printsipy diagnostiki i lecheniya) [Dissertation]. Moscow: Endocrinology Research Centre; 2011.]Lundgren E, Lind L, Palmér M, Jakobsson S, Ljunghall S, Rastad J. Increased cardiovascular mortality and normalized serum calcium in patients with mild hypercalcemia followed up for 25 years. Surgery 2001;130(6):978-985. PMID: 11742326. doi: 10.1067/msy.2001.118377.Lundgren E, Lind L, Palmér M, Jakobsson S, Ljunghall S, Rastad J. Increased cardiovascular mortality and normalized serum calcium in patients with mild hypercalcemia followed up for 25 years. Surgery 2001;130(6):978-985. PMID: 11742326. doi: 10.1067/msy.2001.118377.Kumar S, Olukoga AO, Gordon C, Mawer EB, France M, Hosker JP, et al. Impaired glucose tolerance and insulin insensitivity in primary hyperparathyroidism. Clin Endocrinol 1994;40(1):47-53. PMID: 8306480. doi: 10.1111/j.1365-2265.1994.tb02442.x.Kumar S, Olukoga AO, Gordon C, Mawer EB, France M, Hosker JP, et al. Impaired glucose tolerance and insulin insensitivity in primary hyperparathyroidism. Clin Endocrinol 1994;40(1):47-53. PMID: 8306480. doi: 10.1111/j.1365-2265.1994.tb02442.x.Procopio M, Borretta G. Derangement of glucose metabolism in hyperparathyroidism. J Endocrinol Invest;26(11):1136-1142. doi: 10.1007/BF03345264.Procopio M, Borretta G. Derangement of glucose metabolism in hyperparathyroidism. J Endocrinol Invest;26(11):1136-1142. doi: 10.1007/BF03345264.Lundgren E, Ljunghall S, Åkerström G, Hetta J, Mallmin H, Rastad J. Case-control study on symptoms and signs of “asymptomatic” primary hyperparathyroidism. Surgery 1998;124(6):980-986. PMID: 9854572. doi: 10.1016/S0039-6060(98)70038-8.Lundgren E, Ljunghall S, Åkerström G, Hetta J, Mallmin H, Rastad J. Case-control study on symptoms and signs of “asymptomatic” primary hyperparathyroidism. Surgery 1998;124(6):980-986. PMID: 9854572. doi: 10.1016/S0039-6060(98)70038-8.Schiffl H, Lang SM. Hypertension Secondary to PHPT: Cause or Coincidence. International Journal of Endocrinology 2011;2011:1-6. doi: 10.1155/2011/974647.Schiffl H, Lang SM. Hypertension Secondary to PHPT: Cause or Coincidence. International Journal of Endocrinology 2011;2011:1-6. doi: 10.1155/2011/974647.Curione M, Amato S, Bona, S. Di , Petramala L, Cotesta D, Letizia C. Parathyroidectomy erase increased myocardial electrical vulnerability in patients with primary hyperparathyroidism. International Journal of Cardiology 2010;141(2):201-202. doi: 10.1016/j.ijcard.2008.11.067.Curione M, Amato S, Bona, S. Di , Petramala L, Cotesta D, Letizia C. Parathyroidectomy erase increased myocardial electrical vulnerability in patients with primary hyperparathyroidism. International Journal of Cardiology 2010;141(2):201-202. doi: 10.1016/j.ijcard.2008.11.067.Heyliger A, Tangpricha V, Weber C, Sharma J. Parathyroidectomy decreases systolic and diastolic blood pressure in hypertensive patients with primary hyperparathyroidism. Surgery 2009;146(6):1042-1047. PMID: 19958931. doi: 10.1016/j.surg.2009.09.024.Heyliger A, Tangpricha V, Weber C, Sharma J. Parathyroidectomy decreases systolic and diastolic blood pressure in hypertensive patients with primary hyperparathyroidism. Surgery 2009;146(6):1042-1047. PMID: 19958931. doi: 10.1016/j.surg.2009.09.024.Tordjman KM, Yaron M, Izkhakov E, Osher E, Shenkerman G, Marcus-Perlman Y, et al. Cardiovascular risk factors and arterial rigidity are similar in asymptomatic normocalcemic and hypercalcemic primary hyperparathyroidism. European Journal of Endocrinology 2010;162(5):925-933. doi: 10.1530/EJE-09-1067.Tordjman KM, Yaron M, Izkhakov E, Osher E, Shenkerman G, Marcus-Perlman Y, et al. Cardiovascular risk factors and arterial rigidity are similar in asymptomatic normocalcemic and hypercalcemic primary hyperparathyroidism. European Journal of Endocrinology 2010;162(5):925-933. doi: 10.1530/EJE-09-1067.Rossi GP. Hyperparathyroidism, arterial hypertension and aortic stiffness: a possible bidirectional link between the adrenal cortex and the parathyroid glands that causes vascular damage. Hypertens Res 2010;34(3):286-288. PMID: 21160479. doi: 10.1038/hr.2010.251.Rossi GP. Hyperparathyroidism, arterial hypertension and aortic stiffness: a possible bidirectional link between the adrenal cortex and the parathyroid glands that causes vascular damage. Hypertens Res 2010;34(3):286-288. PMID: 21160479. doi: 10.1038/hr.2010.251.Andersson P, Rydberg E, Willenheimer R. Primary hyperparathyroidism and heart disease: a review. European Heart Journal 2004;25(20):1776-1787. PMID: 15474692. doi: 10.1016/j.ehj.2004.07.010.Andersson P, Rydberg E, Willenheimer R. Primary hyperparathyroidism and heart disease: a review. European Heart Journal 2004;25(20):1776-1787. PMID: 15474692. doi: 10.1016/j.ehj.2004.07.010.Vestergaard P. Cohort study on effects of parathyroid surgery on multiple outcomes in primary hyperparathyroidism. BMJ 2003;327(7414):530-534. doi: 10.1136/bmj.327.7414.530.Vestergaard P. Cohort study on effects of parathyroid surgery on multiple outcomes in primary hyperparathyroidism. BMJ 2003;327(7414):530-534. doi: 10.1136/bmj.327.7414.530.McCarty MF, Thomas CA. PTH excess may promote weight gain by impeding catecholamine-induced lipolysis-implications for the impact of calcium, vitamin D, and alcohol on body weight. Med Hypotheses;61(5-6):535-542. PMID: 14592784.McCarty MF, Thomas CA. PTH excess may promote weight gain by impeding catecholamine-induced lipolysis-implications for the impact of calcium, vitamin D, and alcohol on body weight. Med Hypotheses;61(5-6):535-542. PMID: 14592784.Bolland MJ, Grey AB, Gamble GD, Reid IR. Association between Primary Hyperparathyroidism and Increased Body Weight: A Meta-Analysis. The Journal of Clinical Endocrinology & Metabolism 2005;90(3):1525-1530. doi: 10.1210/jc.2004-1891.Bolland MJ, Grey AB, Gamble GD, Reid IR. Association between Primary Hyperparathyroidism and Increased Body Weight: A Meta-Analysis. The Journal of Clinical Endocrinology & Metabolism 2005;90(3):1525-1530. doi: 10.1210/jc.2004-1891.Luigi P, Chiara FM, Laura Z, Cristiano M, Giuseppina C, Luciano C, et al. Arterial Hypertension, Metabolic Syndrome and Subclinical Cardiovascular Organ Damage in Patients with Asymptomatic Primary Hyperparathyroidism before and after Parathyroidectomy: Preliminary Results. International Journal of Endocrinology 2012;2012:1-10. PMID: 22719761. doi: 10.1155/2012/408295.Luigi P, Chiara FM, Laura Z, Cristiano M, Giuseppina C, Luciano C, et al. Arterial Hypertension, Metabolic Syndrome and Subclinical Cardiovascular Organ Damage in Patients with Asymptomatic Primary Hyperparathyroidism before and after Parathyroidectomy: Preliminary Results. International Journal of Endocrinology 2012;2012:1-10. PMID: 22719761. doi: 10.1155/2012/408295.Bollerslev J, Rosen T, Mollerup CL, Nordenström J, Baranowski M, Franco C, et al. Effect of Surgery on Cardiovascular Risk Factors in Mild Primary Hyperparathyroidism. The Journal of Clinical Endocrinology & Metabolism 2009;94(7):2255-2261. doi: 10.1210/jc.2008-2742.Bollerslev J, Rosen T, Mollerup CL, Nordenström J, Baranowski M, Franco C, et al. Effect of Surgery on Cardiovascular Risk Factors in Mild Primary Hyperparathyroidism. The Journal of Clinical Endocrinology & Metabolism 2009;94(7):2255-2261. doi: 10.1210/jc.2008-2742.

The authors declare that there are no conflicts of interest present.