ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/omet201443-11ometendo-6561Research ArticleОбзор литературыReviewЭффекты бариатрических операций на уровень гормонов, регулирующих массу тела. В чем основа успеха?Effects of bariatric surgery on the level of hormones that regulate body weight. What is the basis of success?БабенкоАлина ЮрьевнаBabenkoAlina Yur'evna

д.м.н., доцент кафедры

alina_babenko@mail.ruНеймаркАлександр ЕвгеньевичNeymarkAleksandr Evgen'evich

к.м.н., ведущий научный сотрудник ФГБУ «ФМИЦ им.В.А. Алмазова».

Доцент кафедры факультетской хирургии ГБОУ ВПО ПСПбГМУ им. И.П. Павлова

sas_spb@mail.ruАнисимоваКристина АлександровнаAnisimovaKristina Aleksandrovna

клинический ординатор

clinical residence

anisimova-k-a@mail.ruГриневаЕлена НиколаевнаGrineva Elena NikolaevnaElena Nikolaevna Nikolaevna

д.м.н., профессор, директор института эндокринологии ФГБУ«ФМИЦ им. В.А. Алмазова»

grineva_e@mail.ruФГБУ "ФМИЦ им.В.А.Алмазова" ГБОУ ВПО "ПСПБГМУ им.акад.И.П.Павлова"РоссияFederal Almazov Medical Research CentreRussian FederationФГБУ "ФМИЦ им.В.А.Алмазова" ГБОУ ВПО "ПСПБГМУ им.акад.И.П.Павлова"РоссияFederal Almazov Medical Research Centre Pavlov First Saint Petersburg State Medical UniversityRussian FederationГБОУ ВПО "ПСПБГМУ им.акад.И.П.Павлова"РоссияFederal Almazov Medical Research Centre Pavlov First Saint Petersburg State Medical UniversityRussian Federation201429062014114311Copyright © Бабенко А.Ю., Неймарк А.Е., Анисимова К.А., Гринева Е.Н., 20142014Бабенко А.Ю., Неймарк А.Е., Анисимова К.А., Гринева Е.Н.Babenko A.Y., Neymark A.E., Anisimova K.A., Grineva Elena Nikolaevna E.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/6561

Растущая заболеваемость ожирением и сахарным диабетом 2 типа сделала бариатрическую хирургию широко распространенным методом лечения. Эффективность бариатрических операций в лечении ожирения и сопутствующих метаболических нарушений хорошо освещена в литературе. Тем не менее, результаты этих вмешательств не всегда коррелируют с типом операции. По-прежнему до конца не изучены механизмы влияния бариатрических вмешательств на инсулинорезистенность, энтеро-инсулярную ось, адипокины. Понимание этих механизмов позволит более точно определять показания к хирургическому лечению и повысить эффективность операции у конкретного пациента. Обзор посвящен влиянию различных типов бариатрических операций на уровень гормонов жировой ткани и желудочно-кишечного тракта, участвующих в регуляции аппетита, жирового и углеводного обмена. В статье рассмотрены современные представления о воздействии бариатрических вмешательств на метаболические нарушения при ожирение.

The growth of obesity and type 2 diabetes incidence has made bariatric surgery a widespread method of treatment. The effectiveness of bariatricoperations in the treatment of obesity and related metabolic diseases is thoroughly highlighted in medical literature. However, the resultsof surgery do not always correlate with type of operation. As before, the mechanisms have not been fully studied of how the bariatric surgeryinfluence on insulinresistance, entero-insulin axes, adipokines. Understanding such mechanisms will allow us to determine more precisely theindications relating to surgical treatment, and enhance the effectiveness of surgery in specific patient. The review is focusing on the influence ofvarious types of bariatric surgery on the level of adipokines and incretines that participate in regulation of appetite and of fat and carbohydratemetabolism. The article elaborates modern concepts related to the impact of bariatric operations on metabolic disorders in obesity.

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The authors declare that there are no conflicts of interest present.