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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ometendo</journal-id><journal-title-group><journal-title xml:lang="ru">Ожирение и метаболизм</journal-title><trans-title-group xml:lang="en"><trans-title>Obesity and metabolism</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2071-8713</issn><issn pub-type="epub">2306-5524</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/omet201223-10</article-id><article-id custom-type="elpub" pub-id-type="custom">ometendo-6539</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Инкретины и их влияние на течение сахарного диабета 2 типа у пациентов с морбидным ожирением после бариатрических операций</article-title><trans-title-group xml:lang="en"><trans-title>Incretins and their influence on the course of type 2 diabetes in patients with morbid obesity after bariatric oper</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Dedov</surname><given-names>I I</given-names></name></name-alternatives><email xlink:type="simple">libr@endocrincentr.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Yashkov</surname><given-names>Yu I</given-names></name></name-alternatives><email xlink:type="simple">Yashkov@celt.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Ershova</surname><given-names>E V</given-names></name></name-alternatives><email xlink:type="simple">Yu99pol06@rambler.ru</email></contrib></contrib-group><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>15</day><month>06</month><year>2012</year></pub-date><volume>9</volume><issue>2</issue><issue-title>№2 (2012)</issue-title><fpage>3</fpage><lpage>10</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Dedov I.I., Yashkov Y.I., Ershova E.V., 2012</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="ru">Dedov I.I., Yashkov Y.I., Ershova E.V.</copyright-holder><copyright-holder xml:lang="en">Dedov I.I., Yashkov Y.I., Ershova E.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.omet-endojournals.ru/jour/article/view/6539">https://www.omet-endojournals.ru/jour/article/view/6539</self-uri><abstract><p>Большинство исследователей подтверждают значимую роль инкретинов, особенно глюкагон-подобного пептида-1, в улучшении метаболического контроля у пациентов с сахарным диабетом 2 типа (СД2) после бариатрических операций, в основном шунтирующих. О положительном влиянии бариатрических операций на течение СД2 известно из многочисленных публикаций, посвященных результатам хирургического лечения морбидного ожирения.</p></abstract><trans-abstract xml:lang="en"><p>Most researchers support the important role of incretins, particularly glucagon-like peptide-1 in improving metabolic control in patients with type 2 diabetes after bariatric operations, mostly involving shunting. A positive effect of bariatric surgery for type 2 diabetes is known from numerous publications on the results of surgical treatment of morbid obesity and in this review we try to analyze the mechanisms of this effect.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>морбидное ожирение</kwd><kwd>сахарный диабет 2 типа</kwd><kwd>бариатрические операции</kwd><kwd>инкретины</kwd></kwd-group><kwd-group xml:lang="en"><kwd>morbid obesity</kwd><kwd>type 2 diabetes</kwd><kwd>bariatric surgery</kwd><kwd>incretins</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Яшков ЮИ. Эффективность хирургических методов лечения ожирения при сахарном диабете II типа. Хирургия 2000;12:49-54.</mixed-citation><mixed-citation xml:lang="en">Яшков ЮИ. Эффективность хирургических методов лечения ожирения при сахарном диабете II типа. Хирургия 2000;12:49-54.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Вaggio L, Drucker D. Biology of incretins: GLP-1 and GIP. Gastroenterology 2007;132:2131-57.</mixed-citation><mixed-citation xml:lang="en">Вaggio L, Drucker D. Biology of incretins: GLP-1 and GIP. Gastroenterology 2007;132:2131-57.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Bailey C, Wilkes L, Conlon J. et al. Effects of gastric inhibitory polypeptide, vasoactive intestinal polypeptide and peptide histidine isoleucine on the secretion of hormones by isolated mouse pancreatic islets. J Endocrinology 1990;125:375-79.</mixed-citation><mixed-citation xml:lang="en">Bailey C, Wilkes L, Conlon J. et al. Effects of gastric inhibitory polypeptide, vasoactive intestinal polypeptide and peptide histidine isoleucine on the secretion of hormones by isolated mouse pancreatic islets. J Endocrinology 1990;125:375-79.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Bayliss W, Starling E. The mechanism of pancreatic secretion. J Physiol 1902;28:325-53.</mixed-citation><mixed-citation xml:lang="en">Bayliss W, Starling E. The mechanism of pancreatic secretion. J Physiol 1902;28:325-53.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Bollag R, Zhong Q, Ding K. et al. Glucose-dependent insulinotropic peptide is an integrative hormone with osteotropic effects. Mol Cell Endocrinol 2001;177:35-41.</mixed-citation><mixed-citation xml:lang="en">Bollag R, Zhong Q, Ding K. et al. Glucose-dependent insulinotropic peptide is an integrative hormone with osteotropic effects. Mol Cell Endocrinol 2001;177:35-41.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Brown J, Dryburgh J. Gastric Inhibitory Polypeptide. II. The complete amino acid sequence. Can. J. Biochem 1971;49:867-72.</mixed-citation><mixed-citation xml:lang="en">Brown J, Dryburgh J. Gastric Inhibitory Polypeptide. II. The complete amino acid sequence. Can. J. Biochem 1971;49:867-72.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Buchwald H, Avidor Y, Braunwald E. et al. Bariatric surgery: a systematic review and meta-analysis. JAMA 2004;292:1724-37.</mixed-citation><mixed-citation xml:lang="en">Buchwald H, Avidor Y, Braunwald E. et al. Bariatric surgery: a systematic review and meta-analysis. JAMA 2004;292:1724-37.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Buchwald H, Estok R, Fahrbach K. et al. Trends in mortality in bariatric surgery: a systematic review and meta-analysis. Surgery 2007;142:621-32.</mixed-citation><mixed-citation xml:lang="en">Buchwald H, Estok R, Fahrbach K. et al. Trends in mortality in bariatric surgery: a systematic review and meta-analysis. Surgery 2007;142:621-32.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Buchwald H, Estok R, Fahrbach K. et al. Weight and type 2 diabetes after bariatric surgery: systematic review and meta-analysis. Am J Med 2009;122:249-61.</mixed-citation><mixed-citation xml:lang="en">Buchwald H, Estok R, Fahrbach K. et al. Weight and type 2 diabetes after bariatric surgery: systematic review and meta-analysis. Am J Med 2009;122:249-61.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Buchwald H, Varco R. Metabolic Surgery. New York: Grune &amp;amp; Stratton 1978. chap 11.</mixed-citation><mixed-citation xml:lang="en">Buchwald H, Varco R. Metabolic Surgery. New York: Grune &amp;amp; Stratton 1978. chap 11.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Сummings D, Overduin J, Foster-Schubert K. Gastric bypass for obesity: mechanisms of weight loss and diabetes resolution. J Clin Endocrinol Metab 2004;89:2608-15.</mixed-citation><mixed-citation xml:lang="en">Сummings D, Overduin J, Foster-Schubert K. Gastric bypass for obesity: mechanisms of weight loss and diabetes resolution. J Clin Endocrinol Metab 2004;89:2608-15.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Drucker D. The biology of incretin hormones. Сell Metabolism 2006;3:153-65.</mixed-citation><mixed-citation xml:lang="en">Drucker D. The biology of incretin hormones. Сell Metabolism 2006;3:153-65.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Drucker D. The role of gut hormones in glucose homeostasis. J Clin Invest 2007;117:24-32.</mixed-citation><mixed-citation xml:lang="en">Drucker D. The role of gut hormones in glucose homeostasis. J Clin Invest 2007;117:24-32.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Ehses J, Casilla V, Doty T. et al. Glucose-dependent insulinotropic polypeptide promotes beta-cell survival via cyclic adenosine monophosphate-mediated caspase-3 inhibition and regulation of p-38 mitigen-activated protein kinase. Endocrinology 2003;144:4433-45.</mixed-citation><mixed-citation xml:lang="en">Ehses J, Casilla V, Doty T. et al. Glucose-dependent insulinotropic polypeptide promotes beta-cell survival via cyclic adenosine monophosphate-mediated caspase-3 inhibition and regulation of p-38 mitigen-activated protein kinase. Endocrinology 2003;144:4433-45.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Elrick H, Stimmler L, Hlad C, Arai Y. Plasma insulin response to oral and intravenous glucose administration. J Clin Endocrinol Metab 1964;24:1076-82.</mixed-citation><mixed-citation xml:lang="en">Elrick H, Stimmler L, Hlad C, Arai Y. Plasma insulin response to oral and intravenous glucose administration. J Clin Endocrinol Metab 1964;24:1076-82.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Holst J, Gromada J. Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans. Am J Physiol Endocrinol Metab 2004;287:E199-Е206.</mixed-citation><mixed-citation xml:lang="en">Holst J, Gromada J. Role of incretin hormones in the regulation of insulin secretion in diabetic and nondiabetic humans. Am J Physiol Endocrinol Metab 2004;287:E199-Е206.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Holst J, Vislboll T, Deacon C. The incretin system and its role in type 2 diabetes mellitus. Mol Cell Endocrinol 2009;297:127-36.</mixed-citation><mixed-citation xml:lang="en">Holst J, Vislboll T, Deacon C. The incretin system and its role in type 2 diabetes mellitus. Mol Cell Endocrinol 2009;297:127-36.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Kim W, Egan J. The role of incretins in glucose homeostasis and diabetes treatment. Pharmacol Rev 2008;60:470-512.</mixed-citation><mixed-citation xml:lang="en">Kim W, Egan J. The role of incretins in glucose homeostasis and diabetes treatment. Pharmacol Rev 2008;60:470-512.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Laferrere B, Heshka S, Wang K et al. Incretin levels and effect are markedly enhanced 1 month after Roux-en-Y gastric bypass surgery in obese patients with type 2 diabetes. Diabetes Care 2007;30:1709-16.</mixed-citation><mixed-citation xml:lang="en">Laferrere B, Heshka S, Wang K et al. Incretin levels and effect are markedly enhanced 1 month after Roux-en-Y gastric bypass surgery in obese patients with type 2 diabetes. Diabetes Care 2007;30:1709-16.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">MacDonald K, Long S, Swanson M et al. The gastric bypass operation reduces the progression and mortality of non-insulin-dependent diabetes mellitus. J Gastrointest Surg 1997;1:213-20.</mixed-citation><mixed-citation xml:lang="en">MacDonald K, Long S, Swanson M et al. The gastric bypass operation reduces the progression and mortality of non-insulin-dependent diabetes mellitus. J Gastrointest Surg 1997;1:213-20.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Mason E. The mechanism of type 2 diabetes. Obes Surg 2005;15:459-61.</mixed-citation><mixed-citation xml:lang="en">Mason E. The mechanism of type 2 diabetes. Obes Surg 2005;15:459-61.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Moore B, Edie E, Abram J. On the treatment of diabetes mellitus by acid extract of duodenal mucosa membrane. Biochem J 1906;1:28-38.</mixed-citation><mixed-citation xml:lang="en">Moore B, Edie E, Abram J. On the treatment of diabetes mellitus by acid extract of duodenal mucosa membrane. Biochem J 1906;1:28-38.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Naslund E, Bogefors J, Skogar S et al. GLP-1 slows solid gastric emptying and inhibits insulin, glucagon, and PYY release in humans. Am J Physiol 1999;277:R910-16.</mixed-citation><mixed-citation xml:lang="en">Naslund E, Bogefors J, Skogar S et al. GLP-1 slows solid gastric emptying and inhibits insulin, glucagon, and PYY release in humans. Am J Physiol 1999;277:R910-16.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Nauck M. Unraveling the science of incretin biology. Am J Med 2009;122:S3-S10.</mixed-citation><mixed-citation xml:lang="en">Nauck M. Unraveling the science of incretin biology. Am J Med 2009;122:S3-S10.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Nauck M, Kleine N, Űrskov C. et al. Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in Type 2 (non-insulin-dependent) diabetic patients. Diabetologia 1993;36:741-44.</mixed-citation><mixed-citation xml:lang="en">Nauck M, Kleine N, Űrskov C. et al. Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in Type 2 (non-insulin-dependent) diabetic patients. Diabetologia 1993;36:741-44.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Nauck M, Stockmann F, Ebert R. et al. Reduced incretin effect in type 2 (non-insulin-dependent) diabetes. Diabetologia 1986;29:46-52.</mixed-citation><mixed-citation xml:lang="en">Nauck M, Stockmann F, Ebert R. et al. Reduced incretin effect in type 2 (non-insulin-dependent) diabetes. Diabetologia 1986;29:46-52.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Neumiller J. Differential chemistry (structure), mechanism of action, and pharmacology of GLP-1 receptor agonists and DPP-4 inhibitors. J Am Pharm Assos 2009;49(1):S16-29.</mixed-citation><mixed-citation xml:lang="en">Neumiller J. Differential chemistry (structure), mechanism of action, and pharmacology of GLP-1 receptor agonists and DPP-4 inhibitors. J Am Pharm Assos 2009;49(1):S16-29.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Nikolaidis L, Mankad S, Sokos G et al. Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion. Circulation 2004;109(8):962-65.</mixed-citation><mixed-citation xml:lang="en">Nikolaidis L, Mankad S, Sokos G et al. Effects of glucagon-like peptide-1 in patients with acute myocardial infarction and left ventricular dysfunction after successful reperfusion. Circulation 2004;109(8):962-65.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Perfetti R. The role of GLP-1 in the regulation of the islet cell mass. Medscape Diabet Endocrinol 2004;6(2):134-38.</mixed-citation><mixed-citation xml:lang="en">Perfetti R. The role of GLP-1 in the regulation of the islet cell mass. Medscape Diabet Endocrinol 2004;6(2):134-38.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Perley M, Kipins D. Plasma insulin responces to oral and intravenous glucose: studies in normal and diabetic subjects. J Clin Invest 1967;46:1954-62.</mixed-citation><mixed-citation xml:lang="en">Perley M, Kipins D. Plasma insulin responces to oral and intravenous glucose: studies in normal and diabetic subjects. J Clin Invest 1967;46:1954-62.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Pories W. Prevention and control of type 2 diabetes mellitus with gastric bypass surgery. International J Obesity 1998;22:S85.</mixed-citation><mixed-citation xml:lang="en">Pories W. Prevention and control of type 2 diabetes mellitus with gastric bypass surgery. International J Obesity 1998;22:S85.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Pories W. Remission of type 2 diabetes mellitus following the gastric bypass operation: timing and magnitude of weight loss. Progress in obesity research: 8, Edited by B.Guy-Grand and G. Ailhaud Lohn Libbey &amp;amp; Company Ltd. 8th Internatuional Congress on Obesity 1999:511-16.</mixed-citation><mixed-citation xml:lang="en">Pories W. Remission of type 2 diabetes mellitus following the gastric bypass operation: timing and magnitude of weight loss. Progress in obesity research: 8, Edited by B.Guy-Grand and G. Ailhaud Lohn Libbey &amp;amp; Company Ltd. 8th Internatuional Congress on Obesity 1999:511-16.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Pories W, Caro J, Flickinger E et al. The control of diabetes mellitus in the morbidly obese with the Greenville Gastric Bypass. Ann Surg 1987;206:316-23.</mixed-citation><mixed-citation xml:lang="en">Pories W, Caro J, Flickinger E et al. The control of diabetes mellitus in the morbidly obese with the Greenville Gastric Bypass. Ann Surg 1987;206:316-23.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Pories W, Dohm G. Full and Durable Remission of Type 2 Diabetes? Through Surgery? Surg Obes Relat Dis 2009;5(2):285-88.</mixed-citation><mixed-citation xml:lang="en">Pories W, Dohm G. Full and Durable Remission of Type 2 Diabetes? Through Surgery? Surg Obes Relat Dis 2009;5(2):285-88.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Pories W, MacDonald K, Flickinger E et al. Is type II diabetes mellitus a surgical disease? Ann Surg 1992;215(6):633-42.</mixed-citation><mixed-citation xml:lang="en">Pories W, MacDonald K, Flickinger E et al. Is type II diabetes mellitus a surgical disease? Ann Surg 1992;215(6):633-42.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Pories W, Swanson M, MacDonald K et al. Who would have thought it? An operation proves to be the most effective therapy for adult onset diabetes mellitus. Ann Surg 1995;222:339-52.</mixed-citation><mixed-citation xml:lang="en">Pories W, Swanson M, MacDonald K et al. Who would have thought it? An operation proves to be the most effective therapy for adult onset diabetes mellitus. Ann Surg 1995;222:339-52.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Ranganath L. The enteroinsular axis: implications for human metabolism. Clin Chem Lab Med 2008;46:43-56.</mixed-citation><mixed-citation xml:lang="en">Ranganath L. The enteroinsular axis: implications for human metabolism. Clin Chem Lab Med 2008;46:43-56.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Rodieux F, Giusti V, D' Alessio D et al. Effects of gastric bypass and gastric banding on glucose kinetics and gut hormone release. Obesity (Silver Spring) 2008;16:298-305.</mixed-citation><mixed-citation xml:lang="en">Rodieux F, Giusti V, D' Alessio D et al. Effects of gastric bypass and gastric banding on glucose kinetics and gut hormone release. Obesity (Silver Spring) 2008;16:298-305.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">le Roux C, Welbourn R, Werling M et al. Gut hormones as mediators of appetite and weight loss after Roux-en-Y gastric bypass. Annals of Surgery 2007;246(5):780-85.</mixed-citation><mixed-citation xml:lang="en">le Roux C, Welbourn R, Werling M et al. Gut hormones as mediators of appetite and weight loss after Roux-en-Y gastric bypass. Annals of Surgery 2007;246(5):780-85.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Rubino F, Gagner M. Potencial of surgery for curing type 2 diabetes mellitus. Ann Surg 2002;236:554-59.</mixed-citation><mixed-citation xml:lang="en">Rubino F, Gagner M. Potencial of surgery for curing type 2 diabetes mellitus. Ann Surg 2002;236:554-59.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Salinari S, Bertuzzi A, Asnaghi S et al. First-phase insulin secretion restoration and differential response to glucose load depending on the route of administration in type 2 diabetic subjects after bariatric surgery. Diabetes Care 2009;32:375-80.</mixed-citation><mixed-citation xml:lang="en">Salinari S, Bertuzzi A, Asnaghi S et al. First-phase insulin secretion restoration and differential response to glucose load depending on the route of administration in type 2 diabetic subjects after bariatric surgery. Diabetes Care 2009;32:375-80.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Schmidt W, Siegel E, Creutzfeld W. Glucagon-like peptide-1 but not glucagon-like peptide-2 stimulates insulin release from isolated rat pancreatic islets. Diabetologia 1985;28:704-7.</mixed-citation><mixed-citation xml:lang="en">Schmidt W, Siegel E, Creutzfeld W. Glucagon-like peptide-1 but not glucagon-like peptide-2 stimulates insulin release from isolated rat pancreatic islets. Diabetologia 1985;28:704-7.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Scopinaro N, Papadia F, Camerini G et al. A comparison of a personal series of biliopancreatic diversion and literature data on gastric bypass help to explain the mechanisms of resolution of type 2 diabetes by the two operations. Obes Surg 2008;18:1035-38.</mixed-citation><mixed-citation xml:lang="en">Scopinaro N, Papadia F, Camerini G et al. A comparison of a personal series of biliopancreatic diversion and literature data on gastric bypass help to explain the mechanisms of resolution of type 2 diabetes by the two operations. Obes Surg 2008;18:1035-38.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Sjostrom L, Lindroos A, Peltonen M et al. Swedish Obese Subjects Study Scientific Group. Lifestyle, diabetes and cardiovascular risk factors 10 years after bariatric surgery. N Eng J Med 2004;351: 2683-93.</mixed-citation><mixed-citation xml:lang="en">Sjostrom L, Lindroos A, Peltonen M et al. Swedish Obese Subjects Study Scientific Group. Lifestyle, diabetes and cardiovascular risk factors 10 years after bariatric surgery. N Eng J Med 2004;351: 2683-93.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Toft-Nielsen M, Damholt M, Madsbad S et al. Determinats of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patients. J Clin Endocrinol Metab 2001;86:3717-23.</mixed-citation><mixed-citation xml:lang="en">Toft-Nielsen M, Damholt M, Madsbad S et al. Determinats of the impaired secretion of glucagon-like peptide-1 in type 2 diabetic patients. J Clin Endocrinol Metab 2001;86:3717-23.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Vilsboll T, Krarup T, Deacon C et al. Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients. Diabetes 2001;50:609-13.</mixed-citation><mixed-citation xml:lang="en">Vilsboll T, Krarup T, Deacon C et al. Reduced postprandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients. Diabetes 2001;50:609-13.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Wideman R, Kieffer T. Glucose-dependent insulinotropic polypeptide as a regulator of beta cell function and fate. Hormone and metabolic research 2004;36:782-86.</mixed-citation><mixed-citation xml:lang="en">Wideman R, Kieffer T. Glucose-dependent insulinotropic polypeptide as a regulator of beta cell function and fate. Hormone and metabolic research 2004;36:782-86.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
