ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/2071-8713-5313ometendo-5313Research ArticleСтатьиArticlesМетоды количественной оценки инсулинорезистентностиMethods for guantificative assessment of insulin resistanceMayorovA Yufoot@endocrincent.ruUrbanovaK A-GalstyanG R-MayorovA Yu-UrbanovaK A-GalstyanG R-20091506200962№2 (2009)1923Copyright © Mayorov A.Y., Urbanova K.A., Galstyan G.R., Mayorov A.Y., Urbanova K.A., Galstyan G.R., 20092009Mayorov A.Y., Urbanova K.A., Galstyan G.R., Mayorov A.Y., Urbanova K.A., Galstyan G.R.Mayorov A.Y., Urbanova K.A., Galstyan G.R., Mayorov A.Y., Urbanova K.A., Galstyan G.R.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/5313

В статье представлено определение понятия инсулинорезистентности, а также факторы, определяющие чувствительность тканей к инсулину, описана концепция синдрома инсулинорезистентности (метаболического синдрома), представлены его критерии, перечислены основные заболевания, сопровождающиеся инсулинорезистентностью. Подчеркнуто, что золотым стандартом количественной оценки действия инсулина является гиперинсулинемический эугликемический клэмп. Обсуждаются также различные индексы для косвенной оценки инсулинорезистентности и возможности использования математических моделей для этих целей.

The article delineates the definition of concept of insulin resistance as well as the factors that determine tissue insulin sensitivity; defines the conception of «insulin resistance syndrome» (metabolic syndrome), its criteria and diseases that it accompanies. It is pointed that the golden standard for quantitative assessment of insulin action is hyperinsulinemic euglycemic clamp. Different indexes for indirect measurement of insulin resistance and possibilities of use of mathematical models for this matter are discussed.

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The authors declare that there are no conflicts of interest present.