ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/2071-8713-5311ometendo-5311Research ArticleСтатьиArticlesВлияние терапии орлистатом (ксеникал) на липиды крови у больных ожирениемThe influence of orlistat (Xenical) therapy on the parameters of lipid metabolism in patients with obesityMazurinaN Vnatalyamazurina@mail.ruMasurinaN V-20091506200962№2 (2009)711Copyright © Mazurina N.V., Masurina N.V., 20092009Mazurina N.V., Masurina N.V.Mazurina N.V., Masurina N.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/5311

Одной из основных целей лечения ожирения является снижение общего кардиометаболического риска, который во многом определяется атерогенными изменениями липидного спектра крови. Данные научных публикаций, представленные в этом обзоре, подтверждают, что орлистат 120 мг является эффективным препаратом для лечения ожирения, назначение которого значительно увеличивает долю пациентов, достигающих клинически значимых результатов. Механизм действия орлистата 120 мг определяет его влияние на показатели липидного спектра крови, которое не зависит напрямую от снижения массы тела на фоне лечения. Улучшение кардиометаболических показателей на фоне применения орлистата позволяет рассматривать этот вариант терапии как один из методов коррекции дислипидемии.

One of the main goals in treatment of obesity is descending of overall cardiometabolic risk, which is mostly defined by atherogenic changes in blood lipid spectrum. Scientific data, presented in this review confirm that orlistat is effective for treatment of obesity, its introduction significantly increases proportion of patients who reach clinically valuable results. The mechanism of action of orlistat explains its influence on parameters of blood lipids, which doesn't directly depend on the decrease of body mass during treatment. Improvement of cardiometabolic parameters during orlistsat treatment allows to consider this therapy as one of the methods for correction of dyslipidemia

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The authors declare that there are no conflicts of interest present.