ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/2071-8713-5308ometendo-5308Research ArticleСтатьиArticlesМетаболические эффекты гормона ростаMetabolicheskie effekty gormona rostaVorotnikovaS Yubra_svetix@list.ruPigarovaE Akpigarova@gmail.comDzeranovaL Kmetabol@endocrincentr.ru20111512201184№4 (2011)5559Copyright © Vorotnikova S.Y., Pigarova E.A., Dzeranova L.K., 20112011Vorotnikova S.Y., Pigarova E.A., Dzeranova L.K.Vorotnikova S.Y., Pigarova E.A., Dzeranova L.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/5308ReferencesArumugam R., Fleenor D., Freemark M. Effects of lactogen resistance and GH deficiency on mouse metabolism: pancreatic hormones, adipocytokines, and expression of adiponectin and insulin receptors // Endocrine. - 2007. - №32. - P. 182-191.Arumugam R., Fleenor D., Freemark M. Effects of lactogen resistance and GH deficiency on mouse metabolism: pancreatic hormones, adipocytokines, and expression of adiponectin and insulin receptors // Endocrine. - 2007. - №32. - P. 182-191.Berryman D.E., List E.O., Coschigano K.T., Behar K., Kim J.K., Kopchick J.J. Comparing adiposity profiles in three mouse models with altered GH signaling // Growth Horm. IGF Res. - 2004. - №14. - P. 309-318.Berryman D.E., List E.O., Coschigano K.T., Behar K., Kim J.K., Kopchick J.J. Comparing adiposity profiles in three mouse models with altered GH signaling // Growth Horm. IGF Res. - 2004. - №14. - P. 309-318.Cho Y., Ariga M., Uchijima Y., Kimura K., Rho J.Y., Furuhata Y., Hakuno F., Yamanouchi K., Nishihara M., Takahashi S. The novel roles of liver for compensation of insulin resistance in human growth hormone transgenic rats // Endocrinology. - 2006. - №147. - P. 5374-5384.Cho Y., Ariga M., Uchijima Y., Kimura K., Rho J.Y., Furuhata Y., Hakuno F., Yamanouchi K., Nishihara M., Takahashi S. The novel roles of liver for compensation of insulin resistance in human growth hormone transgenic rats // Endocrinology. - 2006. - №147. - P. 5374-5384.Cornford A.S., Barkan A.L., Horowitz J.F. Rapid suppression of growth hormone concentration by overeating: potential mediation by hyperinsulinemia // J Clin Endocrinol Metab. - 2011. - №96. - P. 824-830.Cornford A.S., Barkan A.L., Horowitz J.F. Rapid suppression of growth hormone concentration by overeating: potential mediation by hyperinsulinemia // J Clin Endocrinol Metab. - 2011. - №96. - P. 824-830.Cui Y., Hosui A., Sun R., Shen K., Gavrilova O., Chen W., Cam M.C., Gao B., Robinson G.W., Hennighausen L. Loss of signal transducer and activator of transcription 5 leads to hepatosteatosis and impaired liver regeneration // Hepatology. - 2007. - №46. - P. 504-513. 6. del Rincon J.P., Iida K., Gaylinn B.D., McCurdy C.E., Leitner J.W., Barbour L.A.,Cui Y., Hosui A., Sun R., Shen K., Gavrilova O., Chen W., Cam M.C., Gao B., Robinson G.W., Hennighausen L. Loss of signal transducer and activator of transcription 5 leads to hepatosteatosis and impaired liver regeneration // Hepatology. - 2007. - №46. - P. 504-513. 6. del Rincon J.P., Iida K., Gaylinn B.D., McCurdy C.E., Leitner J.W., Barbour L.A.,Kopchick J.J., Friedman J.E., Draznin B., Thorner M.O. Growth hormone regulation of p85alpha expression and phosphoinositide 3-kinase activity in adipose tissue: mechanism for growth hormone-mediated insulin resistance // Diabets. - 2007. - №56. - P. 1638-1646.Kopchick J.J., Friedman J.E., Draznin B., Thorner M.O. Growth hormone regulation of p85alpha expression and phosphoinositide 3-kinase activity in adipose tissue: mechanism for growth hormone-mediated insulin resistance // Diabets. - 2007. - №56. - P. 1638-1646.Erman A., Wabitsch M., Goodyer C.G. Human growth hormone receptor (GHR) expression in obesity: II. Regulation of the human GHR gene by obesity-related factors // Int J Obes (Lond). - 2011. - №8. [Epub ahead of print].Erman A., Wabitsch M., Goodyer C.G. Human growth hormone receptor (GHR) expression in obesity: II. Regulation of the human GHR gene by obesity-related factors // Int J Obes (Lond). - 2011. - №8. [Epub ahead of print].Fan Y., Menon R.K., Cohen P., Hwang D., Clemens T., DiGirolamo D.J., Kopchick J.J., Le Roith D., Trucco M., Sperling M.A. Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism // J. Biol. Chem. - 2009. - №284. - P. 19937-19944.Fan Y., Menon R.K., Cohen P., Hwang D., Clemens T., DiGirolamo D.J., Kopchick J.J., Le Roith D., Trucco M., Sperling M.A. Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism // J. Biol. Chem. - 2009. - №284. - P. 19937-19944.Frick F., Bohlooly-Y. M., Lindén D., Olsson B., Törnell J., Edén S., Oscarsson J. Long-term growth hormone excess induces marked alterations in lipoprotein metabolism in mice // Am. J. Physiol. Endocrinol. Metab. - 2001. - №281. - P. E1230-E1239.Frick F., Bohlooly-Y. M., Lindén D., Olsson B., Törnell J., Edén S., Oscarsson J. Long-term growth hormone excess induces marked alterations in lipoprotein metabolism in mice // Am. J. Physiol. Endocrinol. Metab. - 2001. - №281. - P. E1230-E1239.Ghanaat F., Tayek J.A. Growth hormone administration increases glucose production by preventing the expected decrease in glycogenolysis seen with fasting in healthy volunteers // Metab. Clin. Exp. - 2005. - №54. - P. 604-609.Ghanaat F., Tayek J.A. Growth hormone administration increases glucose production by preventing the expected decrease in glycogenolysis seen with fasting in healthy volunteers // Metab. Clin. Exp. - 2005. - №54. - P. 604-609.Guo Y., Lu Y., Houle D., Robertson K., Tang Z., Kopchick J.J., Liu Y.L., Liu J.L. Pancreatic islet-specific expression of an insulin-like growth factor-I transgene compensates islet cell growth in growth hormone receptor gene-deficient mice // Endocrinology. - 2005. - №146. - P. 2602-2609.Guo Y., Lu Y., Houle D., Robertson K., Tang Z., Kopchick J.J., Liu Y.L., Liu J.L. Pancreatic islet-specific expression of an insulin-like growth factor-I transgene compensates islet cell growth in growth hormone receptor gene-deficient mice // Endocrinology. - 2005. - №146. - P. 2602-2609.Jensen J., Galsgaard E.D., Karlsen A.E., Lee Y.C., Nielsen J.H. STAT5 activation by human GH protects insulin-producing cells against interleukin-1beta, interferongamma and tumour necrosis factor-alpha-induced apoptosis independent of nitric oxide production // J Endocrinol. - 2005. - №187. - P. 25-36.Jensen J., Galsgaard E.D., Karlsen A.E., Lee Y.C., Nielsen J.H. STAT5 activation by human GH protects insulin-producing cells against interleukin-1beta, interferongamma and tumour necrosis factor-alpha-induced apoptosis independent of nitric oxide production // J Endocrinol. - 2005. - №187. - P. 25-36.Kaplan W., Sunehag A. L., Dao H., Haymond M.W. Shortterms effects of recombinant human growth hormone and feeding on gluconeogenesis in humans. // Metab. Clan. - 2008. - №57. - P. 725-723.Kaplan W., Sunehag A. L., Dao H., Haymond M.W. Shortterms effects of recombinant human growth hormone and feeding on gluconeogenesis in humans. // Metab. Clan. - 2008. - №57. - P. 725-723.Kelder B., Berryman D.E., Clark R., Li A., List E.O., Kopchick J.J. CIDE-A gene expression is decreased in white adipose tissue of growth hormone receptor/binding protein gene disrupted mice and with high-fat feeding of normal mice // Growth Horm. IGH Res. - 2007. - №17 - P. 346-351.Kelder B., Berryman D.E., Clark R., Li A., List E.O., Kopchick J.J. CIDE-A gene expression is decreased in white adipose tissue of growth hormone receptor/binding protein gene disrupted mice and with high-fat feeding of normal mice // Growth Horm. IGH Res. - 2007. - №17 - P. 346-351.Kok P., Buijs M.M., Kok S.W., Van Ierssel I.H., Frölich M., Roelfsema F., Voshol P.J., Meinders A.E., Pijl H. Acipimox enhances spontaneous growth hormone secretion in obese women // Am J Physiol Regul Integr Comp Physiol. - 2004 - №286. - P. 693-698.Kok P., Buijs M.M., Kok S.W., Van Ierssel I.H., Frölich M., Roelfsema F., Voshol P.J., Meinders A.E., Pijl H. Acipimox enhances spontaneous growth hormone secretion in obese women // Am J Physiol Regul Integr Comp Physiol. - 2004 - №286. - P. 693-698.Kotelevtsev Y., Holmes M.C., Burchell A., Houston P.M., Schmoll D., Jamieson P., Best R., Brown R., Edwards C.R., Seckl J.R., Mullins J.J. 11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress // Proc. Natl. acad. Sci. U.S.A. - 1997. - №94. - P. 14924-14929.Kotelevtsev Y., Holmes M.C., Burchell A., Houston P.M., Schmoll D., Jamieson P., Best R., Brown R., Edwards C.R., Seckl J.R., Mullins J.J. 11beta-hydroxysteroid dehydrogenase type 1 knockout mice show attenuated glucocorticoid-inducible responses and resist hyperglycemia on obesity or stress // Proc. Natl. acad. Sci. U.S.A. - 1997. - №94. - P. 14924-14929.Lin S.C., Li P. CIDE-A, a novel link between brown adipose tissue and obesity // Trends Mol. Med. - 2004. - №10. - P. 434-439.Lin S.C., Li P. CIDE-A, a novel link between brown adipose tissue and obesity // Trends Mol. Med. - 2004. - №10. - P. 434-439.Lindberg-Larsen R., Møller N., Schmitz O., Nielsen S., Andersen M., Orskov H., Jørgensen J.O. The impact of pegvisomant treatment on substrate metabolism and insulin sensitivity in patients with acromegaly // J. Clin. Endocrinol. Metab. - 2007. - №92. - P. 1724-1728.Lindberg-Larsen R., Møller N., Schmitz O., Nielsen S., Andersen M., Orskov H., Jørgensen J.O. The impact of pegvisomant treatment on substrate metabolism and insulin sensitivity in patients with acromegaly // J. Clin. Endocrinol. Metab. - 2007. - №92. - P. 1724-1728.Maccario M., Procopio M., Grottoli S., Oleandri S.E., Boffano G.M., Taliano M., Camanni F., Ghigo E. Effects of acipimox, an antilipolytic drug, on the growth hormone (GH) response to GH-releasing hormone alone or combined with arginine in obesity // Metabolism. - 1996. - №45. - P. 342-346.Maccario M., Procopio M., Grottoli S., Oleandri S.E., Boffano G.M., Taliano M., Camanni F., Ghigo E. Effects of acipimox, an antilipolytic drug, on the growth hormone (GH) response to GH-releasing hormone alone or combined with arginine in obesity // Metabolism. - 1996. - №45. - P. 342-346.Mauvais-Jarvis F., Ueki K., Fruman D.A., Hirshman M.F., Sakamoto K., Goodyear L.J., Iannacone M., Accili D., Cantley L.C., Kahn C.R. Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes // J. Clin. Invest. - 2002. - №109. - P. 141-149.Mauvais-Jarvis F., Ueki K., Fruman D.A., Hirshman M.F., Sakamoto K., Goodyear L.J., Iannacone M., Accili D., Cantley L.C., Kahn C.R. Reduced expression of the murine p85alpha subunit of phosphoinositide 3-kinase improves insulin signaling and ameliorates diabetes // J. Clin. Invest. - 2002. - №109. - P. 141-149.Mavalli M.D., DiGirolamo D.J., Fan Y., Riddle R.C., Campbell K.S., van Groen T., Frank S.J., Sperling M.A., Esser K.A., Bamman M.M., Clemens T.L. Distinct growth hormone receptor signaling modes regulate skeletal muscle development and insulin sensitivity in mice // J Clin Invest. - 2010. - №120. - P. 4007-4020.Mavalli M.D., DiGirolamo D.J., Fan Y., Riddle R.C., Campbell K.S., van Groen T., Frank S.J., Sperling M.A., Esser K.A., Bamman M.M., Clemens T.L. Distinct growth hormone receptor signaling modes regulate skeletal muscle development and insulin sensitivity in mice // J Clin Invest. - 2010. - №120. - P. 4007-4020.
The authors declare that there are no conflicts of interest present.