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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ometendo</journal-id><journal-title-group><journal-title xml:lang="ru">Ожирение и метаболизм</journal-title><trans-title-group xml:lang="en"><trans-title>Obesity and metabolism</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2071-8713</issn><issn pub-type="epub">2306-5524</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/2071-8713-5256</article-id><article-id custom-type="elpub" pub-id-type="custom">ometendo-5256</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Роль лептина в нарушении репродуктивной функции при ожирении</article-title><trans-title-group xml:lang="en"><trans-title>Rol' leptina v narushenii reproduktivnoy funktsii pri ozhirenii</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Митиш</surname><given-names>Драган</given-names></name><name name-style="western" xml:lang="en"><surname>Mitsich</surname><given-names>Dragan</given-names></name></name-alternatives><email xlink:type="simple">omet@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Тсвиович</surname><given-names>Горан</given-names></name><name name-style="western" xml:lang="en"><surname>Tsviyovich</surname><given-names>Goran</given-names></name></name-alternatives><email xlink:type="simple">omet@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кендерешки</surname><given-names>Александра</given-names></name><name name-style="western" xml:lang="en"><surname>Kendereshki</surname><given-names>Aleksandra</given-names></name></name-alternatives><email xlink:type="simple">omet@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Шумарац-Думанович</surname><given-names>Мирьяна</given-names></name><name name-style="western" xml:lang="en"><surname>Shumarats-Dumanovich</surname><given-names>Mir'yana</given-names></name></name-alternatives><email xlink:type="simple">omet@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Зорич</surname><given-names>Светлана</given-names></name><name name-style="western" xml:lang="en"><surname>Zorich</surname><given-names>Svetlana</given-names></name></name-alternatives><email xlink:type="simple">omet@endojournals.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Пейкович</surname><given-names>Даница</given-names></name><name name-style="western" xml:lang="en"><surname>Peykovich</surname><given-names>Danitsa</given-names></name></name-alternatives><email xlink:type="simple">omet@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Маркович</surname><given-names>Кристина</given-names></name><name name-style="western" xml:lang="en"><surname>Markovich</surname><given-names>Kristina</given-names></name></name-alternatives><email xlink:type="simple">omet@endojournals.ru</email><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>&lt;p&gt;Институт Эндокринологии, Диабета и Болезней Метаболизма,&amp;nbsp;Клинический Центр Сербии, Др Суботича, Белград&lt;/p&gt;</institution><country>Serbia</country></aff><pub-date pub-type="collection"><year>2006</year></pub-date><pub-date pub-type="epub"><day>15</day><month>09</month><year>2006</year></pub-date><volume>3</volume><issue>3</issue><issue-title>№3 (2006)</issue-title><fpage>2</fpage><lpage>8</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Митиш Д., Тсвиович Г., Кендерешки А., Шумарац-Думанович М., Зорич С., Пейкович Д., Маркович К., 2006</copyright-statement><copyright-year>2006</copyright-year><copyright-holder xml:lang="ru">Митиш Д., Тсвиович Г., Кендерешки А., Шумарац-Думанович М., Зорич С., Пейкович Д., Маркович К.</copyright-holder><copyright-holder xml:lang="en">Mitsich D., Tsviyovich G., Kendereshki A., Shumarats-Dumanovich M., Zorich S., Peykovich D., Markovich K.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.omet-endojournals.ru/jour/article/view/5256">https://www.omet-endojournals.ru/jour/article/view/5256</self-uri><abstract><p>.</p></abstract><trans-abstract xml:lang="en"><p>.</p></trans-abstract></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Agarwal SJ, Vogel K, Weitsman SR. et al. Leptin antagonizes the insulin-like growth factor-I augmentation of steroidogenesis in granulose and theca cells of the human ovary. Journal of Clinical Endocrinology and Metabolism 1999; 84: 1072 -1076.</mixed-citation><mixed-citation xml:lang="en">Agarwal SJ, Vogel K, Weitsman SR. et al. Leptin antagonizes the insulin-like growth factor-I augmentation of steroidogenesis in granulose and theca cells of the human ovary. Journal of Clinical Endocrinology and Metabolism 1999; 84: 1072 -1076.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Ashworth CJ, Hoggard N, Thomas L, et al. Placental leptin. Rev Reprod. 2000; 5: 18-24.</mixed-citation><mixed-citation xml:lang="en">Ashworth CJ, Hoggard N, Thomas L, et al. Placental leptin. Rev Reprod. 2000; 5: 18-24.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Baldelli R, Dieguez C, Casanueva FF. The role of leptin in reproduction : experimental and clinical aspects. Ann Med 2002; 34: 5-18.</mixed-citation><mixed-citation xml:lang="en">Baldelli R, Dieguez C, Casanueva FF. The role of leptin in reproduction : experimental and clinical aspects. Ann Med 2002; 34: 5-18.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Banks WA: Leptin transport across the blood-brain barrier: implications for the cause and treatment of obesity. Curr Pharm Des 2001; 7: 125-133.</mixed-citation><mixed-citation xml:lang="en">Banks WA: Leptin transport across the blood-brain barrier: implications for the cause and treatment of obesity. Curr Pharm Des 2001; 7: 125-133.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Barash IA, Cheung CC, Weigle DS, et al. Leptin is a metabolic signal to the reproductive system. Endocrinology. 1996; 137: 3144-7.</mixed-citation><mixed-citation xml:lang="en">Barash IA, Cheung CC, Weigle DS, et al. Leptin is a metabolic signal to the reproductive system. Endocrinology. 1996; 137: 3144-7.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Blum WF, Englaro P, Hanitsch S, et al. Plasma leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage, and testosterone. J Clin Endocrinol Metab. 1997; 82: 2904-3010.</mixed-citation><mixed-citation xml:lang="en">Blum WF, Englaro P, Hanitsch S, et al. Plasma leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage, and testosterone. J Clin Endocrinol Metab. 1997; 82: 2904-3010.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Bongain A, Isnard V, Gillet JY. Obesity in obstetrics and gynaecology. European Journal of Obestrics &amp;amp; Gynecology and Reproductive Biology 1998; 77: 217 - 228.</mixed-citation><mixed-citation xml:lang="en">Bongain A, Isnard V, Gillet JY. Obesity in obstetrics and gynaecology. European Journal of Obestrics &amp;amp; Gynecology and Reproductive Biology 1998; 77: 217 - 228.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Brannian JD, Hansen KA. Leptin and Ovarian Folliculogenesis: Implications for Ovulation Induction and ART Outcomes. Seminars in Reproductive Medicine 2002; 20: 103-112.</mixed-citation><mixed-citation xml:lang="en">Brannian JD, Hansen KA. Leptin and Ovarian Folliculogenesis: Implications for Ovulation Induction and ART Outcomes. Seminars in Reproductive Medicine 2002; 20: 103-112.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Bray GA, York DA. Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis. Physiol Rev. 1979; 59: 719-819.</mixed-citation><mixed-citation xml:lang="en">Bray GA, York DA. Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis. Physiol Rev. 1979; 59: 719-819.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Brzechffa PR, Jakimiuk AJ, Agarwal SK, et al. Serum immunoreactive leptin concentrations in women with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism 1996; 81: 4166-4169.</mixed-citation><mixed-citation xml:lang="en">Brzechffa PR, Jakimiuk AJ, Agarwal SK, et al. Serum immunoreactive leptin concentrations in women with polycystic ovary syndrome. Journal of Clinical Endocrinology and Metabolism 1996; 81: 4166-4169.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Caprio M, Fabbrini E, Isidori AM, et al. Leptin in reproduction. Trends in Endocrinology &amp;amp; Metabolism. 2001; 12: 65-72.</mixed-citation><mixed-citation xml:lang="en">Caprio M, Fabbrini E, Isidori AM, et al. Leptin in reproduction. Trends in Endocrinology &amp;amp; Metabolism. 2001; 12: 65-72.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Carmina E, Ferin M, Gonzalez F, et al. Evidence that insulin and androgens may participate in the regulation of serum leptin levels in women. Fertil Steril 1999; 72: 926-931.</mixed-citation><mixed-citation xml:lang="en">Carmina E, Ferin M, Gonzalez F, et al. Evidence that insulin and androgens may participate in the regulation of serum leptin levels in women. Fertil Steril 1999; 72: 926-931.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Casanueva F.F, Dieguez C. Neuroendocrine Regulation and Actions of Leptin. Frontiers in Neuroendocrinology. 1999; 20: 317- 363.</mixed-citation><mixed-citation xml:lang="en">Casanueva F.F, Dieguez C. Neuroendocrine Regulation and Actions of Leptin. Frontiers in Neuroendocrinology. 1999; 20: 317- 363.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Chebab F, Lim M, Lu R. Correction of sterility defect in homozygousobese female mice by treatment with the human recombinant leptin. Nat Genetics. 1996; 12: 318-20.</mixed-citation><mixed-citation xml:lang="en">Chebab F, Lim M, Lu R. Correction of sterility defect in homozygousobese female mice by treatment with the human recombinant leptin. Nat Genetics. 1996; 12: 318-20.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Cioffi J.A, Blerkom J, Antczak M, et al. The expression of leptin and its receptors in pre-ovulatory human follicles. Mol Hum Reprod 1997; 3: 467 -472.</mixed-citation><mixed-citation xml:lang="en">Cioffi J.A, Blerkom J, Antczak M, et al. The expression of leptin and its receptors in pre-ovulatory human follicles. Mol Hum Reprod 1997; 3: 467 -472.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Clement K, Vaisse C, Lahlou N.: A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998; 392: 398-401.</mixed-citation><mixed-citation xml:lang="en">Clement K, Vaisse C, Lahlou N.: A mutation in the human leptin receptor gene causes obesity and pituitary dysfunction. Nature 1998; 392: 398-401.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Correa H, Jacoby J. Nutrition and fertility: some iconoclastic results. Am J Clin Nutr. 1978; 31: 1431-6.</mixed-citation><mixed-citation xml:lang="en">Correa H, Jacoby J. Nutrition and fertility: some iconoclastic results. Am J Clin Nutr. 1978; 31: 1431-6.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Couce ME, Burguera B, Parisi JE, et al. Localization of leptin receptor in the human brain. Neuroendocrinology. 1997; 66: 145-50.</mixed-citation><mixed-citation xml:lang="en">Couce ME, Burguera B, Parisi JE, et al. Localization of leptin receptor in the human brain. Neuroendocrinology. 1997; 66: 145-50.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Devos R, Richards JG, Campfield LA, et al. OB protein binds specifically to the choroid plexus of mice and rats. Proc Natl Acad Sci USA. 1996; 93: 5668-73.</mixed-citation><mixed-citation xml:lang="en">Devos R, Richards JG, Campfield LA, et al. OB protein binds specifically to the choroid plexus of mice and rats. Proc Natl Acad Sci USA. 1996; 93: 5668-73.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Dorn C, Reinsberg J, Kupka M, et al. Leptin, VEGF, IGF-1, and IFFBP-3 concentrations in serum and follicular fluid of women undergoing in vitro fertilization. Arch Gynecol Obstet 2003; 268: 187-193.</mixed-citation><mixed-citation xml:lang="en">Dorn C, Reinsberg J, Kupka M, et al. Leptin, VEGF, IGF-1, and IFFBP-3 concentrations in serum and follicular fluid of women undergoing in vitro fertilization. Arch Gynecol Obstet 2003; 268: 187-193.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Dubuc PU. The development of obestity, hyperinsulinemia and hyperglycemia in ob/ob mice. Metabolism. 1976; 25: 1567-74.</mixed-citation><mixed-citation xml:lang="en">Dubuc PU. The development of obestity, hyperinsulinemia and hyperglycemia in ob/ob mice. Metabolism. 1976; 25: 1567-74.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Elmquist JK, Bjorbaek C, Ahima RS, et al. Distribution of leptin receptor mRNA isoforms in the rat brain. J Comp Neurol. 1998; 395: 535-47.</mixed-citation><mixed-citation xml:lang="en">Elmquist JK, Bjorbaek C, Ahima RS, et al. Distribution of leptin receptor mRNA isoforms in the rat brain. J Comp Neurol. 1998; 395: 535-47.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Fei H, Okano HJ, Li C, et al. Anatomic localization of alternately spliced leptin receptors (OB-R) in the mouse brain and other tissues. Neurobiology. 1997; 94: 7001-5.</mixed-citation><mixed-citation xml:lang="en">Fei H, Okano HJ, Li C, et al. Anatomic localization of alternately spliced leptin receptors (OB-R) in the mouse brain and other tissues. Neurobiology. 1997; 94: 7001-5.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Franks S. Growth hormone and ovarian function. Baillieres Clin Endocrinol Metab. 1998; 12: 331-40.</mixed-citation><mixed-citation xml:lang="en">Franks S. Growth hormone and ovarian function. Baillieres Clin Endocrinol Metab. 1998; 12: 331-40.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Frisch R, Revelle R.: Height and weight at menarche and hypothesis of critical body weights and adolescent events. Science 197; 169: 397 - 399.</mixed-citation><mixed-citation xml:lang="en">Frisch R, Revelle R.: Height and weight at menarche and hypothesis of critical body weights and adolescent events. Science 197; 169: 397 - 399.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Galtier-Dereure F, Montpeyroux F, Boulot P, et al. Weight excess before pregnancy: complications and cost. Int J Obes Rel Metab Disord. 1995; 19: 443-8.</mixed-citation><mixed-citation xml:lang="en">Galtier-Dereure F, Montpeyroux F, Boulot P, et al. Weight excess before pregnancy: complications and cost. Int J Obes Rel Metab Disord. 1995; 19: 443-8.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Garcia MC, Casanueva FF, Dieguez C, Senaris RM. Gestational profile of leptin messenger ribonucleic acid (mRNA) content in the placenta and adipose tissue in the rat, and regulation of the mRNA levels of the leptin receptor subtypes in the hypotalamus during pregnancy and lactation. Biol Reprod. 2000; 62: 698-703.</mixed-citation><mixed-citation xml:lang="en">Garcia MC, Casanueva FF, Dieguez C, Senaris RM. Gestational profile of leptin messenger ribonucleic acid (mRNA) content in the placenta and adipose tissue in the rat, and regulation of the mRNA levels of the leptin receptor subtypes in the hypotalamus during pregnancy and lactation. Biol Reprod. 2000; 62: 698-703.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Garcia-Mayor RV, Andrade MA, Rios M, et al. Serum leptin levels in normal children: relationship to age, gender, body mass index, pituitary-gonadal hormones and pubertal stage. J Clin Endocrinol Metab. 1997; 82: 2849-55.</mixed-citation><mixed-citation xml:lang="en">Garcia-Mayor RV, Andrade MA, Rios M, et al. Serum leptin levels in normal children: relationship to age, gender, body mass index, pituitary-gonadal hormones and pubertal stage. J Clin Endocrinol Metab. 1997; 82: 2849-55.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Glasow A, Haidan A, Hilbers U, et. Expression of Ob receptors in normal human adrenals: differential regulation of adrenocortical and adrenomedullary function by leptin. J Clin Endocrinol Metab. 1998; 83: 4459-67.</mixed-citation><mixed-citation xml:lang="en">Glasow A, Haidan A, Hilbers U, et. Expression of Ob receptors in normal human adrenals: differential regulation of adrenocortical and adrenomedullary function by leptin. J Clin Endocrinol Metab. 1998; 83: 4459-67.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Goumenou A, Matalliotakis I, Koumantakis G, Panidis D: The role of leptin in fertility. European Journal of Obstetrics &amp;amp; Gynecology and Reproductive Biology 2003; 106: 118-124.</mixed-citation><mixed-citation xml:lang="en">Goumenou A, Matalliotakis I, Koumantakis G, Panidis D: The role of leptin in fertility. European Journal of Obstetrics &amp;amp; Gynecology and Reproductive Biology 2003; 106: 118-124.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Gross P, Werhya G, Seng G. Obesite: epidemiologie et risques de l'obesite. Rev Prat. 1989; 39: 2355-60.</mixed-citation><mixed-citation xml:lang="en">Gross P, Werhya G, Seng G. Obesite: epidemiologie et risques de l'obesite. Rev Prat. 1989; 39: 2355-60.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Guan XM, Hess JF, Yu H, Hey PJ, van der Ploeg LH. Differential expression of mRNA for leptin receptor isoforms in the rat brain. Mol Cell Endocrinol. 1997; 133: 1-7.</mixed-citation><mixed-citation xml:lang="en">Guan XM, Hess JF, Yu H, Hey PJ, van der Ploeg LH. Differential expression of mRNA for leptin receptor isoforms in the rat brain. Mol Cell Endocrinol. 1997; 133: 1-7.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Hakansson ML, Browh H, Ghilardi N, et al. Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus. J Neurosci. 1998; 18: 559-72.</mixed-citation><mixed-citation xml:lang="en">Hakansson ML, Browh H, Ghilardi N, et al. Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus. J Neurosci. 1998; 18: 559-72.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Hardie L, Trayhurn P, Abramovich D, Fowler P. Circulating leptin in women: a longitudinal study in the menstrual cycle and during pregnancy. Clin Endocrinol. 1997; 47: 101-6.</mixed-citation><mixed-citation xml:lang="en">Hardie L, Trayhurn P, Abramovich D, Fowler P. Circulating leptin in women: a longitudinal study in the menstrual cycle and during pregnancy. Clin Endocrinol. 1997; 47: 101-6.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Hartz AJ, Barboriak PN, Wong A, et al. The association of obesity with infertility and related menstrual abnormalities in women. Int J Obesity. 1979; 3: 57-60.</mixed-citation><mixed-citation xml:lang="en">Hartz AJ, Barboriak PN, Wong A, et al. The association of obesity with infertility and related menstrual abnormalities in women. Int J Obesity. 1979; 3: 57-60.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Hassink SG, de Lancey E, Sheslow DV, et al. Placental leptin: an important new growth factor in intrauterine and neonatal development? Pediatrics. 1997; 100: E1-E6.</mixed-citation><mixed-citation xml:lang="en">Hassink SG, de Lancey E, Sheslow DV, et al. Placental leptin: an important new growth factor in intrauterine and neonatal development? Pediatrics. 1997; 100: E1-E6.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Henson MC, Castracane VD. Leptin in pregnancy. Biol Reprod. 2000; 63: 1219-28.</mixed-citation><mixed-citation xml:lang="en">Henson MC, Castracane VD. Leptin in pregnancy. Biol Reprod. 2000; 63: 1219-28.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Highman TJ, Friedman JE, Huston LP, et al. Longitudinal changes in maternal serum leptin concetrations, body composition and resting metabolic rate in pregnancy. Am J Obstet Gynecol. 1998; 178: 1010-5.</mixed-citation><mixed-citation xml:lang="en">Highman TJ, Friedman JE, Huston LP, et al. Longitudinal changes in maternal serum leptin concetrations, body composition and resting metabolic rate in pregnancy. Am J Obstet Gynecol. 1998; 178: 1010-5.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Hoggard N, Hunter L, Duncan JS, et al. Leptin and leptin receptor mRNA , and protein expression in the murine fetus, and placenta. Proc Natl Acad Sci USA. 1997; 94: 11073-8.</mixed-citation><mixed-citation xml:lang="en">Hoggard N, Hunter L, Duncan JS, et al. Leptin and leptin receptor mRNA , and protein expression in the murine fetus, and placenta. Proc Natl Acad Sci USA. 1997; 94: 11073-8.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Jakubowitz DJ, Nestler JE. 17-alpha hydroxyprogesterone responses to leuprolide and serum androgens in obese women with and without polycystic ovary syndrome after dietary weight loss. J Clin Endocrinol Metab. 1997; 82: 556-60.</mixed-citation><mixed-citation xml:lang="en">Jakubowitz DJ, Nestler JE. 17-alpha hydroxyprogesterone responses to leuprolide and serum androgens in obese women with and without polycystic ovary syndrome after dietary weight loss. J Clin Endocrinol Metab. 1997; 82: 556-60.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Jaquet D, Leger J, Levy Marchal C, et al. Ontogeny of leptin in human fetuses and newborns: Effect of intrauterine growth retardation on serum leptin concentrations. J Clin Endocrinol Metab 1998; 83: 1243 -1246.</mixed-citation><mixed-citation xml:lang="en">Jaquet D, Leger J, Levy Marchal C, et al. Ontogeny of leptin in human fetuses and newborns: Effect of intrauterine growth retardation on serum leptin concentrations. J Clin Endocrinol Metab 1998; 83: 1243 -1246.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Kaltsas T, Pontikides N, Krassas GE et al. Growth hormone response to thyrotropin releasing hormone in women with polycystic ovarian syndrome. Hum Reprod. 1999; 14: 2704-8.</mixed-citation><mixed-citation xml:lang="en">Kaltsas T, Pontikides N, Krassas GE et al. Growth hormone response to thyrotropin releasing hormone in women with polycystic ovarian syndrome. Hum Reprod. 1999; 14: 2704-8.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Karlsson C, Lindell K, Svenssen E, et al. Expression of functional leptin receptors in the human ovary. J Clin Endocrinol Metab. 1997; 82: 4144-8.</mixed-citation><mixed-citation xml:lang="en">Karlsson C, Lindell K, Svenssen E, et al. Expression of functional leptin receptors in the human ovary. J Clin Endocrinol Metab. 1997; 82: 4144-8.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Kaseki H, Maruyama S, Ishihara K, Araki T. Serum leptin concentration in young adult women with ovulatory dysfunction. J Nippon Med Sch 2003; 70: 270- 273.</mixed-citation><mixed-citation xml:lang="en">Kaseki H, Maruyama S, Ishihara K, Araki T. Serum leptin concentration in young adult women with ovulatory dysfunction. J Nippon Med Sch 2003; 70: 270- 273.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Kirel B, Tekin N, Tekin B, et al. Cord blood leptin levels: relationship to body weight, body mass index, sex and insulin and cortisol levels of maternal -newborn pairs at delivery. J Pediatr Endocrinol Metab 2000; 13: 71-77.</mixed-citation><mixed-citation xml:lang="en">Kirel B, Tekin N, Tekin B, et al. Cord blood leptin levels: relationship to body weight, body mass index, sex and insulin and cortisol levels of maternal -newborn pairs at delivery. J Pediatr Endocrinol Metab 2000; 13: 71-77.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Knochenhauer ES, Key TJ, Kahsar-Miller M. et al. Prevalence of polycystic ovary syndrome in unselected black and white women of southeastern United States: a prospective study. J Clin Endocrinol Metab. 1998; 83: 3078-82.</mixed-citation><mixed-citation xml:lang="en">Knochenhauer ES, Key TJ, Kahsar-Miller M. et al. Prevalence of polycystic ovary syndrome in unselected black and white women of southeastern United States: a prospective study. J Clin Endocrinol Metab. 1998; 83: 3078-82.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Lage M, Garcia-Mayor RV, Tome MA, et al. Serum leptin levels in women throughout pregnancy and the postpartum period and in women suffering sponatenous abortion. Clin Endocrinol 1999; 50: 211-216.</mixed-citation><mixed-citation xml:lang="en">Lage M, Garcia-Mayor RV, Tome MA, et al. Serum leptin levels in women throughout pregnancy and the postpartum period and in women suffering sponatenous abortion. Clin Endocrinol 1999; 50: 211-216.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Lahlou N, Landais P, De Boissieu D, Bougneres PF. Circulating leptin in normal children and during the dynamic phase of juvenile obesity: relation to body fatness, energy metabolism, caloric intake, and sexual dimorphism. Diabetes. 1997; 46: 989-93.</mixed-citation><mixed-citation xml:lang="en">Lahlou N, Landais P, De Boissieu D, Bougneres PF. Circulating leptin in normal children and during the dynamic phase of juvenile obesity: relation to body fatness, energy metabolism, caloric intake, and sexual dimorphism. Diabetes. 1997; 46: 989-93.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Le Thai N, Lefebvre G, Stella V, Vauthier D, Sfoggia D, Goulon V, Darbois J. Grossesse et obesite. A propos d'une etude cas-temoin de 140 cas. J Gynecol Obstet Biol Reprod. 1992; 21: 563-7.</mixed-citation><mixed-citation xml:lang="en">Le Thai N, Lefebvre G, Stella V, Vauthier D, Sfoggia D, Goulon V, Darbois J. Grossesse et obesite. A propos d'une etude cas-temoin de 140 cas. J Gynecol Obstet Biol Reprod. 1992; 21: 563-7.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Lebrethon MC, Vandersmissen E, Gerard A, et al. Cocaine and amphetamin-regulated transcript peptide mediation of leptin stimulatory effect on the rat gonadotropin-releasing hormone pulse generator in vitro. J Neuroendocrinol. 2000; 12: 383-5.</mixed-citation><mixed-citation xml:lang="en">Lebrethon MC, Vandersmissen E, Gerard A, et al. Cocaine and amphetamin-regulated transcript peptide mediation of leptin stimulatory effect on the rat gonadotropin-releasing hormone pulse generator in vitro. J Neuroendocrinol. 2000; 12: 383-5.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Lepercq J, Cauzac M, Lahlou N, et al Over-expression of placental leptin in diabetic pregnancy: a critical role for insulin. Diabetes. 1999; 47: 847-50.</mixed-citation><mixed-citation xml:lang="en">Lepercq J, Cauzac M, Lahlou N, et al Over-expression of placental leptin in diabetic pregnancy: a critical role for insulin. Diabetes. 1999; 47: 847-50.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Loffler S, Aust G, Kohler U, Spanel-Borowski K. Evidence of leptin expression in normal and polycystic human ovaries. Mol Hum Reprod 2001; 7: 1143-1149.</mixed-citation><mixed-citation xml:lang="en">Loffler S, Aust G, Kohler U, Spanel-Borowski K. Evidence of leptin expression in normal and polycystic human ovaries. Mol Hum Reprod 2001; 7: 1143-1149.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Lynn RB, Cao GY, Considine RV, et al. Autoradiographic localization of leptin binding in the choroid plexus of ob/ob and db/db mice. Biochem Biophys Res Commun, 1996, 219: 884-9.</mixed-citation><mixed-citation xml:lang="en">Lynn RB, Cao GY, Considine RV, et al. Autoradiographic localization of leptin binding in the choroid plexus of ob/ob and db/db mice. Biochem Biophys Res Commun, 1996, 219: 884-9.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Magni P, Vetter R, Pagano C, et al. Expression of a leptin receptor in immortalized gonadotropin-releasing hormone secreting neurons. Endocrinology. 1999; 140: 1581-5.</mixed-citation><mixed-citation xml:lang="en">Magni P, Vetter R, Pagano C, et al. Expression of a leptin receptor in immortalized gonadotropin-releasing hormone secreting neurons. Endocrinology. 1999; 140: 1581-5.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Mantzoros CS, Flier JS, Rogol AD. A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. V. Rising leptin may signal the onset of puberty. J Clin Endocrinol Metab 1997; 82: 1066 -1070.</mixed-citation><mixed-citation xml:lang="en">Mantzoros CS, Flier JS, Rogol AD. A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. V. Rising leptin may signal the onset of puberty. J Clin Endocrinol Metab 1997; 82: 1066 -1070.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Masuzaki H, Ogawa Y, Sagawa N, et al. Non-adipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nature Med. 1997; 3: 11029-33.</mixed-citation><mixed-citation xml:lang="en">Masuzaki H, Ogawa Y, Sagawa N, et al. Non-adipose tissue production of leptin: leptin as a novel placenta-derived hormone in humans. Nature Med. 1997; 3: 11029-33.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">Micic D, Kendereski A, Popovic V et al. Growth hormone response to GHRH, GHRP-6, and GHRH+GHRP-6 in patients with polycystic ovary syndrome. Clin Endocrinol. 1996; 45: 385-90.</mixed-citation><mixed-citation xml:lang="en">Micic D, Kendereski A, Popovic V et al. Growth hormone response to GHRH, GHRP-6, and GHRH+GHRP-6 in patients with polycystic ovary syndrome. Clin Endocrinol. 1996; 45: 385-90.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Micic D, Sumarac-Dumaovic M, Macut Dj, et al Growth-hormone response to combined stimulation with GHRH plus GH-releasing peptide-6 in obese patients with polycystic ovary syndrome before and after short term fasting. J Endocrinol Invest. 2003; 26: 333-40.</mixed-citation><mixed-citation xml:lang="en">Micic D, Sumarac-Dumaovic M, Macut Dj, et al Growth-hormone response to combined stimulation with GHRH plus GH-releasing peptide-6 in obese patients with polycystic ovary syndrome before and after short term fasting. J Endocrinol Invest. 2003; 26: 333-40.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">Mix H, Widjaja A, Jandl O, et al. Expression of leptin and leptin receptor isoforms in the human stomach. Gut. 2000; 47: 481-6.</mixed-citation><mixed-citation xml:lang="en">Mix H, Widjaja A, Jandl O, et al. Expression of leptin and leptin receptor isoforms in the human stomach. Gut. 2000; 47: 481-6.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">Morales AJ. Role of growth hormone in polycystic ovarian syndrome. Semin Reprod Endocrinol. 1977; 15; 177-82.</mixed-citation><mixed-citation xml:lang="en">Morales AJ. Role of growth hormone in polycystic ovarian syndrome. Semin Reprod Endocrinol. 1977; 15; 177-82.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">Mounzih K, Lu R, Chebab FF. Leptin treatment rescues the sterility of genetically obese ob/ob males. Endocrinology. 1997; 138: 1190-3.</mixed-citation><mixed-citation xml:lang="en">Mounzih K, Lu R, Chebab FF. Leptin treatment rescues the sterility of genetically obese ob/ob males. Endocrinology. 1997; 138: 1190-3.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Nagatani S, Guthikonda P, Thompson RC, et al. Evidence for GnRH regulation by leptin: leptin administration prevents reduced pulsatile LH secretion during fasting. Neuroendocrinology. 1998; 67: 370-6.</mixed-citation><mixed-citation xml:lang="en">Nagatani S, Guthikonda P, Thompson RC, et al. Evidence for GnRH regulation by leptin: leptin administration prevents reduced pulsatile LH secretion during fasting. Neuroendocrinology. 1998; 67: 370-6.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Norman RJ, Clark AM. Obesity and reproductive disorders: a review. Reprod Fertil Dev. 1998; 10: 55-63.</mixed-citation><mixed-citation xml:lang="en">Norman RJ, Clark AM. Obesity and reproductive disorders: a review. Reprod Fertil Dev. 1998; 10: 55-63.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Parent AS, Lebrethon MC, Gerard A, et al. Leptin effects on pulsatile gonadotropin releasing hormone secretion from the adult rat hypothalamus and interaction with cocaine and amphetamine-regulated transcript peptide and neuropeptide Y. Regul Pept. 2000; 92: 17-24.</mixed-citation><mixed-citation xml:lang="en">Parent AS, Lebrethon MC, Gerard A, et al. Leptin effects on pulsatile gonadotropin releasing hormone secretion from the adult rat hypothalamus and interaction with cocaine and amphetamine-regulated transcript peptide and neuropeptide Y. Regul Pept. 2000; 92: 17-24.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Pettigrew R, Hamilton-Fairley D. Obesity and female reproductive function. British Medical Bulletin. 1997; 53: 341-58.</mixed-citation><mixed-citation xml:lang="en">Pettigrew R, Hamilton-Fairley D. Obesity and female reproductive function. British Medical Bulletin. 1997; 53: 341-58.</mixed-citation></citation-alternatives></ref><ref id="cit66"><label>66</label><citation-alternatives><mixed-citation xml:lang="ru">Remsberg KE, Talbot EO, Zborowski JV, et al. Evidence for competing effects of body mass, hyperinsulinemia, insulin resistance, and androgens on leptin levels among lean, overwight, and obese women with polycystic ovary syndrome. Fertility and Sterility. 2002; 78: 479-486.</mixed-citation><mixed-citation xml:lang="en">Remsberg KE, Talbot EO, Zborowski JV, et al. Evidence for competing effects of body mass, hyperinsulinemia, insulin resistance, and androgens on leptin levels among lean, overwight, and obese women with polycystic ovary syndrome. Fertility and Sterility. 2002; 78: 479-486.</mixed-citation></citation-alternatives></ref><ref id="cit67"><label>67</label><citation-alternatives><mixed-citation xml:lang="ru">Sagawa N, Yura S, Itoh H, et al. Possible role of placental leptin in pregnancy: a review. Endocrine 2002; 19: 65-71.</mixed-citation><mixed-citation xml:lang="en">Sagawa N, Yura S, Itoh H, et al. Possible role of placental leptin in pregnancy: a review. Endocrine 2002; 19: 65-71.</mixed-citation></citation-alternatives></ref><ref id="cit68"><label>68</label><citation-alternatives><mixed-citation xml:lang="ru">Strobel A, Issad T, Camoin L, et al. A leptin missense mutation associated with hypogonadism and morbid obesity. Nat Genet 1998; 18: 213-215.</mixed-citation><mixed-citation xml:lang="en">Strobel A, Issad T, Camoin L, et al. A leptin missense mutation associated with hypogonadism and morbid obesity. Nat Genet 1998; 18: 213-215.</mixed-citation></citation-alternatives></ref><ref id="cit69"><label>69</label><citation-alternatives><mixed-citation xml:lang="ru">Tamura T, Goldenberg RL, Johnston JE, Cliver SP. Serum leptin concetrations during pregnancy and their relationship to fetal growth. Obstet Gynecol. 1998; 91: 389-395.</mixed-citation><mixed-citation xml:lang="en">Tamura T, Goldenberg RL, Johnston JE, Cliver SP. Serum leptin concetrations during pregnancy and their relationship to fetal growth. Obstet Gynecol. 1998; 91: 389-395.</mixed-citation></citation-alternatives></ref><ref id="cit70"><label>70</label><citation-alternatives><mixed-citation xml:lang="ru">Yamada M, Irahara M, Tezuka M, et al. Serum leptin profiles in the normal menstrual cycles and gonadotropin treatment cycles. Gynecol Obstet Invest 2000; 49: 119-123.</mixed-citation><mixed-citation xml:lang="en">Yamada M, Irahara M, Tezuka M, et al. Serum leptin profiles in the normal menstrual cycles and gonadotropin treatment cycles. Gynecol Obstet Invest 2000; 49: 119-123.</mixed-citation></citation-alternatives></ref><ref id="cit71"><label>71</label><citation-alternatives><mixed-citation xml:lang="ru">Yu WH, Kimura M, Walczewska A, et al. Role of leptin in hypothalamic-pituitary function. Proc Natl Acad Sci USA. 1997; 94: 1023-8.</mixed-citation><mixed-citation xml:lang="en">Yu WH, Kimura M, Walczewska A, et al. Role of leptin in hypothalamic-pituitary function. Proc Natl Acad Sci USA. 1997; 94: 1023-8.</mixed-citation></citation-alternatives></ref><ref id="cit72"><label>72</label><citation-alternatives><mixed-citation xml:lang="ru">Zamorano PL, Mahesh VB, De Sevilla LM, et al. Expression and localisation of the leptin receptor in endocrine and neuroendocrine tissues of the rat. Neuroendocrinology. 1997; 65: 223-8.</mixed-citation><mixed-citation xml:lang="en">Zamorano PL, Mahesh VB, De Sevilla LM, et al. Expression and localisation of the leptin receptor in endocrine and neuroendocrine tissues of the rat. Neuroendocrinology. 1997; 65: 223-8.</mixed-citation></citation-alternatives></ref><ref id="cit73"><label>73</label><citation-alternatives><mixed-citation xml:lang="ru">Zhang Y, Stern B, and Rebar RW. Endocrine comparision of obese menstruating and amenorrheic women. J Clin Endocrinol Metab. 1984; 58: 1077-83.</mixed-citation><mixed-citation xml:lang="en">Zhang Y, Stern B, and Rebar RW. Endocrine comparision of obese menstruating and amenorrheic women. J Clin Endocrinol Metab. 1984; 58: 1077-83.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
