ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/2071-8713-5240ometendo-5240Research ArticleСтатьиArticlesПотенциальные возможности применения альфа-липоевойкислоты (Берлитион®300) в лечении метаболического синдромаPotential opportunities for treatment of metabolic syndrome withalpha-lipoic acid (Berlithion®300)RomantsovaT Iromantsovatatiana@rambler. ruKuznetsovI S-20091509200963№3 (2009)1014Copyright © Romantsova T.I., Kuznetsov I.S., 20092009Romantsova T.I., Kuznetsov I.S.Romantsova T.I., Kuznetsov I.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/5240

Существует много экспериментальных данных, подтверждающих влияние альфа-липоевой кислоты на активность фермента АМПК, рецепторов PPARα/γ и белков-термогенинов, разобщающих окислительное фосфорилирование (UCP1). АМПК представляет собой фермент, влияющий на потребление пищи и энергетический обмен как на уровне гипоталамуса, так и в периферических тканях. PPARγ является ключевым модулятором липидного гомеостаза и дифференциации адипоцитов. Белок UCP1 содержится в бурой жировой ткани и отвечает за термогенез. Посредством регуляции перечисленных биологических субстратов альфа-липоевая кислота (препарат Берлитион ®300) нормализует инсулинорезистентность, что способствует снижению массы тела и улучшению липидного профиля крови

There are a lot of experi mental data confirmed the influence of alpha-lipoi с acid on activity of AMPK enzyme, receptors PPARα/γ and uncoupling proteins that prev ent oxidative phosphorylation (UCPl). AMPK is the enzyme responsible for food intake and energy expenditure in hypothalamus as w ell as in peripheral adipose tissue. PPARγ is the key modulator of lipid ho meostasis and adipocyte differentiation. UCPl is located in the brown adipose tissue and provides termogenesis. Via regulation of mentioned biological targets alpha-lipoic acid (Berlithion®300) lowers insulinresistance, favors weight losing process and improvement of blood lipid profile.

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The authors declare that there are no conflicts of interest present.