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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ometendo</journal-id><journal-title-group><journal-title xml:lang="ru">Ожирение и метаболизм</journal-title><trans-title-group xml:lang="en"><trans-title>Obesity and metabolism</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2071-8713</issn><issn pub-type="epub">2306-5524</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/2071-8713-5218</article-id><article-id custom-type="elpub" pub-id-type="custom">ometendo-5218</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Безопасность метформина с точки зрениягепатолога</article-title><trans-title-group xml:lang="en"><trans-title>Bezopasnost' metformina s tochki zreniyagepatologa</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Bueverov</surname><given-names>A O</given-names></name></name-alternatives><email xlink:type="simple">-</email></contrib></contrib-group><pub-date pub-type="collection"><year>2010</year></pub-date><pub-date pub-type="epub"><day>15</day><month>06</month><year>2010</year></pub-date><volume>7</volume><issue>2</issue><issue-title>№2 (2010)</issue-title><fpage>73</fpage><lpage>76</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Bueverov A.O., 2010</copyright-statement><copyright-year>2010</copyright-year><copyright-holder xml:lang="ru">Bueverov A.O.</copyright-holder><copyright-holder xml:lang="en">Bueverov A.O.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.omet-endojournals.ru/jour/article/view/5218">https://www.omet-endojournals.ru/jour/article/view/5218</self-uri><abstract/><trans-abstract xml:lang="en"/></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Байкова И.Е., Никитин И.Г. Лекарственное поражение печени // РМЖ, 2009; 11: 1-5.</mixed-citation><mixed-citation xml:lang="en">Байкова И.Е., Никитин И.Г. Лекарственное поражение печени // РМЖ, 2009; 11: 1-5.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Буеверов А.О. Возможности лечения лекарственных поражений печени в условиях необходимости приема гепатотоксичных препаратов // Леч. врач, 2009; 2: 40-42.</mixed-citation><mixed-citation xml:lang="en">Буеверов А.О. Возможности лечения лекарственных поражений печени в условиях необходимости приема гепатотоксичных препаратов // Леч. врач, 2009; 2: 40-42.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Буеверов А.О., Богомолов П.О. Неалкогольная жировая болезнь печени: обоснование патогенетической терапии // Клин. перспект. гастроэнтерол. гепа- тол., 2009; 1: 3-9.</mixed-citation><mixed-citation xml:lang="en">Буеверов А.О., Богомолов П.О. Неалкогольная жировая болезнь печени: обоснование патогенетической терапии // Клин. перспект. гастроэнтерол. гепа- тол., 2009; 1: 3-9.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Демидова И.Ю., Горохова Т.В. Механизм действия и клиническое применение метформина (Сиофор®): обзор литературы // Фарматека, 2009; 17: 10-15.</mixed-citation><mixed-citation xml:lang="en">Демидова И.Ю., Горохова Т.В. Механизм действия и клиническое применение метформина (Сиофор®): обзор литературы // Фарматека, 2009; 17: 10-15.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Adeneya A.A., Benebo A.S. Oral metformin-ascorbic acid coadministration ameliorates alcohol-induced hepatotoxicity in rats // Nig. Q. J. Hosp. Med., 2007; 17: 15-159.</mixed-citation><mixed-citation xml:lang="en">Adeneya A.A., Benebo A.S. Oral metformin-ascorbic acid coadministration ameliorates alcohol-induced hepatotoxicity in rats // Nig. Q. J. Hosp. Med., 2007; 17: 15-159.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Caldwell S.H., Argo C.K., Al-Osaimi A.M. Therapy of NAFLD: insulin sensitizing agents // J. Clin. Gastroenterol, 2006; 40: 61-66.</mixed-citation><mixed-citation xml:lang="en">Caldwell S.H., Argo C.K., Al-Osaimi A.M. Therapy of NAFLD: insulin sensitizing agents // J. Clin. Gastroenterol, 2006; 40: 61-66.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Desilets D.J., Shorr A.F., Moran K.A., Holtzmuller K.C. Cholestatic jaundice asoociated with use of metformin // Am. J. Gastroenterol., 2001; 96: 2257-2258.</mixed-citation><mixed-citation xml:lang="en">Desilets D.J., Shorr A.F., Moran K.A., Holtzmuller K.C. Cholestatic jaundice asoociated with use of metformin // Am. J. Gastroenterol., 2001; 96: 2257-2258.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Kozka U., Holma G.D. Metformin blocks down-regulation of cell-surface GLUT4 caused by chronic insulin treatment of rat adipocytes // Diabetes, 1993; 42: 1159-1165.</mixed-citation><mixed-citation xml:lang="en">Kozka U., Holma G.D. Metformin blocks down-regulation of cell-surface GLUT4 caused by chronic insulin treatment of rat adipocytes // Diabetes, 1993; 42: 1159-1165.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Krentz A.J. Comparative safety of newer oral antidiabetic drugs // Expert. Opin. Drug. Saf., 2006; 5: 827-834.</mixed-citation><mixed-citation xml:lang="en">Krentz A.J. Comparative safety of newer oral antidiabetic drugs // Expert. Opin. Drug. Saf., 2006; 5: 827-834.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Kutoh E. Possible metformin-induced hepatotoxicity // Am. J. Geriatr. Pharmacother., 2005; 3: 270-273.</mixed-citation><mixed-citation xml:lang="en">Kutoh E. Possible metformin-induced hepatotoxicity // Am. J. Geriatr. Pharmacother., 2005; 3: 270-273.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Marchesini G. Metformin in non-alcoholic steatohepatitis // Lancet, 2001; 358: 893-894.</mixed-citation><mixed-citation xml:lang="en">Marchesini G. Metformin in non-alcoholic steatohepatitis // Lancet, 2001; 358: 893-894.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Matthaei S., Reibold J.P., Hamann A. et al. In vivo metformin treatment ameliorates insulin resistance: evidence for potentiation of insulin induced translocation and increased functional activity of glucose transporters in obese (fa/fa) Zucker rat adipocytes // Endocrinology, 1993; 133: 304-311.</mixed-citation><mixed-citation xml:lang="en">Matthaei S., Reibold J.P., Hamann A. et al. In vivo metformin treatment ameliorates insulin resistance: evidence for potentiation of insulin induced translocation and increased functional activity of glucose transporters in obese (fa/fa) Zucker rat adipocytes // Endocrinology, 1993; 133: 304-311.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Nammour F.E., Fayad N.F., Peitcin S.R. Metformin-induced cholestatic hepatitis // Endocr. Pract., 2003; 9: 307-309.</mixed-citation><mixed-citation xml:lang="en">Nammour F.E., Fayad N.F., Peitcin S.R. Metformin-induced cholestatic hepatitis // Endocr. Pract., 2003; 9: 307-309.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Poza-Gomes G., Rivero Fernandez F., Vaguez Romero M. et al. Constitutional syndrome associated to metformin induced hepatotoxicity // Gastroenterol. Hepatol., 2008; 31: 643-645.</mixed-citation><mixed-citation xml:lang="en">Poza-Gomes G., Rivero Fernandez F., Vaguez Romero M. et al. Constitutional syndrome associated to metformin induced hepatotoxicity // Gastroenterol. Hepatol., 2008; 31: 643-645.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">U.K. prospective diabetes study: intensive blood glucose control with sulphonylureas and insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS) // Lancet, 1998; 352: 837-853.</mixed-citation><mixed-citation xml:lang="en">U.K. prospective diabetes study: intensive blood glucose control with sulphonylureas and insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS) // Lancet, 1998; 352: 837-853.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Urso R. Metformin in non-alcoholic steatohepatitis // Lancet, 2002; 359: 355-356.</mixed-citation><mixed-citation xml:lang="en">Urso R. Metformin in non-alcoholic steatohepatitis // Lancet, 2002; 359: 355-356.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Zou M.H., Wu Y. AMP-activated proteine kinase activation as a strategy for protecting vascular endothelial function // Clin. Exp. Pharmacol. Physiol., 2008; 35: 535-545.</mixed-citation><mixed-citation xml:lang="en">Zou M.H., Wu Y. AMP-activated proteine kinase activation as a strategy for protecting vascular endothelial function // Clin. Exp. Pharmacol. Physiol., 2008; 35: 535-545.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
