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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ometendo</journal-id><journal-title-group><journal-title xml:lang="ru">Ожирение и метаболизм</journal-title><trans-title-group xml:lang="en"><trans-title>Obesity and metabolism</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2071-8713</issn><issn pub-type="epub">2306-5524</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/2071-8713-5210</article-id><article-id custom-type="elpub" pub-id-type="custom">ometendo-5210</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Клинический случай гигантской пролактин-секретирующей аденомы гипофиза у подростка</article-title><trans-title-group xml:lang="en"><trans-title>Klinicheskiy sluchay gigantskoy prolaktin-sekretiruyushchey adenomy gipofiza u podrostka</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Giniyatullina</surname><given-names>E N</given-names></name></name-alternatives><email xlink:type="simple">toriel7@yahoo.com</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Dzeranova</surname><given-names>L K</given-names></name></name-alternatives><email xlink:type="simple">metabol@endocrincentr.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Grigor'ev</surname><given-names>A Yu</given-names></name></name-alternatives><email xlink:type="simple">medway@list.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Vorontsov</surname><given-names>A V</given-names></name></name-alternatives><email xlink:type="simple">mr2005@mail.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Pigarova</surname><given-names>E A</given-names></name></name-alternatives><email xlink:type="simple">kpigarova@gmail.com</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Rozhinskaya</surname><given-names>L Ya</given-names></name></name-alternatives><email xlink:type="simple">rozh@endocrincentr.ru</email></contrib></contrib-group><pub-date pub-type="collection"><year>2010</year></pub-date><pub-date pub-type="epub"><day>15</day><month>06</month><year>2010</year></pub-date><volume>7</volume><issue>2</issue><issue-title>№2 (2010)</issue-title><fpage>52</fpage><lpage>55</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Giniyatullina E.N., Dzeranova L.K., Grigor'ev A.Y., Vorontsov A.V., Pigarova E.A., Rozhinskaya L.Y., 2010</copyright-statement><copyright-year>2010</copyright-year><copyright-holder xml:lang="ru">Giniyatullina E.N., Dzeranova L.K., Grigor'ev A.Y., Vorontsov A.V., Pigarova E.A., Rozhinskaya L.Y.</copyright-holder><copyright-holder xml:lang="en">Giniyatullina E.N., Dzeranova L.K., Grigor'ev A.Y., Vorontsov A.V., Pigarova E.A., Rozhinskaya L.Y.</copyright-holder><license license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.omet-endojournals.ru/jour/article/view/5210">https://www.omet-endojournals.ru/jour/article/view/5210</self-uri><abstract><p>Резюме. Пролактиномы редко выявляются у лиц детского возраста, но зачастую характеризуются более агрессивным ростом.
И, несмотря на то, что подходы к лечению этих опухолей у взрослых хорошо изучены и в настоящее время предпочтение отдается медикаментозной терапии агонистами дофамина, применение этих препаратов у детей ограничено из-за отсутствия
данных о безопасности и эффективности их применения на этой группе пациентов. Каберголин в качестве медикаментозной
терапии является препаратом выбора в лечении пролактином у взрослых пациентов. Представленный нами клинический
случай демонстрирует высокую эффективность и хорошую переносимость каберголина у мальчика 14 лет с гигантской пролактиномой, осложненной зрительными, неврологическими и метаболическими нарушениями, что позволило на данном
этапе воздержаться от оперативного лечения, а также нивелировать или уменьшить проявления осложнений заболевания.
Resume. Prolactinomas are very rare, but usually more aggressive among children, than in adults. Although treatment strategies for prolactinomas
in adults are well established and at present time the preference is given to dopamine agonists, the use of these drugs in pediatric
patients is limited due to lack of information on safety and efficiency in this group of patients. Cabergoline is a drug of choice for treatment
adult patients with prolactinomas. This clinical case that we report here demonstrates high efficiency and tolerability of cabergoline in a
14-year patient with giant prolactinoma, complicated by visual, neurological and metabolic disturbances, which allowed us to refrain
from surgical treatment and to reduce the degree of complications.</p></abstract><kwd-group xml:lang="ru"><kwd>пролактинома</kwd><kwd>пролактин</kwd><kwd>ПРЛ</kwd><kwd>каберголин</kwd><kwd>дети</kwd><kwd>агонисты дофамина</kwd></kwd-group><kwd-group xml:lang="en"><kwd>prolactinoma</kwd><kwd>prolactin</kwd><kwd>PRL</kwd><kwd>cabergoline</kwd><kwd>children</kwd><kwd>dopamine agonists</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Дедов И.И., Мельниченко Г.А. Персистирующая галакторея-аменорея. М.: Медицина 1985; 253.</mixed-citation><mixed-citation xml:lang="en">Дедов И.И., Мельниченко Г.А. Персистирующая галакторея-аменорея. М.: Медицина 1985; 253.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Романцова Т.И. 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