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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ometendo</journal-id><journal-title-group><journal-title xml:lang="ru">Ожирение и метаболизм</journal-title><trans-title-group xml:lang="en"><trans-title>Obesity and metabolism</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2071-8713</issn><issn pub-type="epub">2306-5524</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/2071-8713-5186</article-id><article-id custom-type="elpub" pub-id-type="custom">ometendo-5186</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Эпидемия ожирения: очевидные и вероятные причины</article-title><trans-title-group xml:lang="en"><trans-title>Epidemiya ozhireniya: ochevidnye i veroyatnye prichiny</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Romantsova</surname><given-names>T I</given-names></name></name-alternatives><email xlink:type="simple">romantsovatatiana@rambler.ru</email></contrib></contrib-group><pub-date pub-type="collection"><year>2011</year></pub-date><pub-date pub-type="epub"><day>15</day><month>03</month><year>2011</year></pub-date><volume>8</volume><issue>1</issue><issue-title>№1 (2011)</issue-title><fpage>5</fpage><lpage>19</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Romantsova T.I., 2011</copyright-statement><copyright-year>2011</copyright-year><copyright-holder xml:lang="ru">Romantsova T.I.</copyright-holder><copyright-holder xml:lang="en">Romantsova T.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.omet-endojournals.ru/jour/article/view/5186">https://www.omet-endojournals.ru/jour/article/view/5186</self-uri><abstract><p>Распространенность ожирения и ассоциированных с ним заболеваний, в том числе СД 2 типа, достигли масштабов
глобальной эпидемии. Несмотря на то, что питание и физическая активность считаются ведущими причинами эпидемии
ожирения, существует множество других факторов окружающей среды, которые могут играть важную роль в его распространении. К ним относятся кишечная микрофлора, недостаток сна, стрессы, социальная среда, эндокринные разрушители и др.
Эти факторы играют ключевую роль в регуляции адипогенеза и аппетита. Необходимо проведение дальнейших исследований
по уточнению патогенеза ожирения.</p></abstract><trans-abstract xml:lang="en"><p>Obesity and obesity-related disorders, such as type 2 diabetes, has become a global epidemic. Although there is abundant
evidence that diet and exercise are key factors in the obesity epidemic, it is equally clear that a variety of environmental factors play an
important role in this process. These include such factors as gut flora, insufficient sleep, stress, social environment, maternal influences,
endocrine disrupters and others. These factors target key hormonal signaling pathways involved in adipogenesis, regulation of appetite.
They are also likely to play important roles in obesity epidemic and are therefore worthy of further study.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>ожирение</kwd><kwd>эпидемия</kwd><kwd>гены</kwd><kwd>эпигенетика</kwd><kwd>циркадные ритмы</kwd><kwd>микрофлора кишечника</kwd><kwd>эндокринные дисрапторы</kwd></kwd-group><kwd-group xml:lang="en"><kwd>obesity</kwd><kwd>epidemic</kwd><kwd>genes</kwd><kwd>epigenetics</kwd><kwd>circadian rhythms</kwd><kwd>gut microbiota</kwd><kwd>endocrine disrupters</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Аульченко Ю. С. Разработка и применение методов полногеномного анализа генетических ассоциаций сложных признаков. Автореферат дисс. доктора биол. наук. Новосибирск. - 2010.</mixed-citation><mixed-citation xml:lang="en">Аульченко Ю. С. Разработка и применение методов полногеномного анализа генетических ассоциаций сложных признаков. Автореферат дисс. доктора биол. наук. Новосибирск. - 2010.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Гвоздев В.А. Регуляция активности генов, обусловленная химической модификацией (метилированием) ДНК. http://nature.web.ru/db/msg. html?mid=1159503&amp;amp;uri=index.html.</mixed-citation><mixed-citation xml:lang="en">Гвоздев В.А. Регуляция активности генов, обусловленная химической модификацией (метилированием) ДНК. http://nature.web.ru/db/msg. html?mid=1159503&amp;amp;uri=index.html.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Дедов И.И. Проблема ожирения: от синдрома к заболеванию // Ожирение и метаболизм. - 2006. - № 1(6). - С. 2-4.</mixed-citation><mixed-citation xml:lang="en">Дедов И.И. Проблема ожирения: от синдрома к заболеванию // Ожирение и метаболизм. - 2006. - № 1(6). - С. 2-4.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Коваленко Т.Ф. Метилирование генома млекопитающих // Молекулярная медицина. - 2010. - № 6. - С. 21-29.</mixed-citation><mixed-citation xml:lang="en">Коваленко Т.Ф. Метилирование генома млекопитающих // Молекулярная медицина. - 2010. - № 6. - С. 21-29.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Никитенко А.С. Нарушение эпигенетической регуляции активности генов и болезни человека // Вестник Российской академии медицинских наук. - 2001. - № 10. - С. 43-48.</mixed-citation><mixed-citation xml:lang="en">Никитенко А.С. Нарушение эпигенетической регуляции активности генов и болезни человека // Вестник Российской академии медицинских наук. - 2001. - № 10. - С. 43-48.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Романцова Т.И. Патогенетический подход к лечению ожирения и сахарного диабета 2 типа // Ожирение и метаболизм. - 2008. - № 4(17). - С. 2-10.</mixed-citation><mixed-citation xml:lang="en">Романцова Т.И. Патогенетический подход к лечению ожирения и сахарного диабета 2 типа // Ожирение и метаболизм. - 2008. - № 4(17). - С. 2-10.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Сонди Л. Учебник экспериментальной диагностики влечений: глубинно-психологическая диагностика и ее применение в психопатологии, психосоматике, судебной психиатрии, криминологии, психофармакологии, профессиональном, семейном и подростковом консультировании, характерологии и этнологии. Пер. с нем. / М.: Когито- Центр. - 2005. - 557 с.</mixed-citation><mixed-citation xml:lang="en">Сонди Л. Учебник экспериментальной диагностики влечений: глубинно-психологическая диагностика и ее применение в психопатологии, психосоматике, судебной психиатрии, криминологии, психофармакологии, профессиональном, семейном и подростковом консультировании, характерологии и этнологии. Пер. с нем. / М.: Когито- Центр. - 2005. - 557 с.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Backhed F., Ding H., Wang T. et al. The gut microbiota as an environmental factor that regulates fat storage // Proc Natl Acad Sci USA. - 2004. - № 101. - Р. 15718-15723.</mixed-citation><mixed-citation xml:lang="en">Backhed F., Ding H., Wang T. et al. The gut microbiota as an environmental factor that regulates fat storage // Proc Natl Acad Sci USA. - 2004. - № 101. - Р. 15718-15723.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Barclay L. Short or Long Sleep Duration Linked to Weight Gain. Sleep. - 2008. - № 31. - Р. 517-523.</mixed-citation><mixed-citation xml:lang="en">Barclay L. Short or Long Sleep Duration Linked to Weight Gain. Sleep. - 2008. - № 31. - Р. 517-523.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Barker D.J.P., Eriksson J.G., Forsén T., Osmond C. Fetal origins of adult disease: strength of effects and biological basis // Int J Epidemiol. - 2002. - № 31. - Р. 1235-1239.</mixed-citation><mixed-citation xml:lang="en">Barker D.J.P., Eriksson J.G., Forsén T., Osmond C. Fetal origins of adult disease: strength of effects and biological basis // Int J Epidemiol. - 2002. - № 31. - Р. 1235-1239.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Campion J., Milagro F.I. Martinez J.A. Individuality and epigenetics in obesity // Obes Rev. - 2009. - № 10. - Р. 383-392.</mixed-citation><mixed-citation xml:lang="en">Campion J., Milagro F.I. Martinez J.A. Individuality and epigenetics in obesity // Obes Rev. - 2009. - № 10. - Р. 383-392.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Cani P.D., Amar J., Iglesias M.A. et al. Metabolic endotoxemia initiates obesity and insulin resistance // Diabetes. - 2007. - № 56. - Р. 1761-1772.</mixed-citation><mixed-citation xml:lang="en">Cani P.D., Amar J., Iglesias M.A. et al. Metabolic endotoxemia initiates obesity and insulin resistance // Diabetes. - 2007. - № 56. - Р. 1761-1772.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Cauter E.V., Knutson K.L. Sleep and the epidemic of obesity in children and adults // Eur J Endocrinol. - 2008. - № 159. - Р. 59-66.</mixed-citation><mixed-citation xml:lang="en">Cauter E.V., Knutson K.L. Sleep and the epidemic of obesity in children and adults // Eur J Endocrinol. - 2008. - № 159. - Р. 59-66.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Chaput J.P., Després J.P., Bouchard C., Tremblay A. Short sleep duration is associated with reduced leptin levels and increased adiposity: results from the Québec Family Study // Obesity. - 2007. - № 15. - Р. 253-261.</mixed-citation><mixed-citation xml:lang="en">Chaput J.P., Després J.P., Bouchard C., Tremblay A. Short sleep duration is associated with reduced leptin levels and increased adiposity: results from the Québec Family Study // Obesity. - 2007. - № 15. - Р. 253-261.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Christakis N.A, Fowler J.H. The spread of obesity in a large social network over 32 years // N Engl J Med. - 2007. - № 357. - Р. 370-379.</mixed-citation><mixed-citation xml:lang="en">Christakis N.A, Fowler J.H. The spread of obesity in a large social network over 32 years // N Engl J Med. - 2007. - № 357. - Р. 370-379.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Cizza G., Marincola P., Mattingly М. et al. Treatment of obesity with extension of sleep duration: a randomized, prospective, controlled trial // Clin Trials. - 2010. - № 7 (3). - Р. 274-285.</mixed-citation><mixed-citation xml:lang="en">Cizza G., Marincola P., Mattingly М. et al. Treatment of obesity with extension of sleep duration: a randomized, prospective, controlled trial // Clin Trials. - 2010. - № 7 (3). - Р. 274-285.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Cotoyannis P., Wildman J. Using relative distributions to investigate the body mass index in England and Canada // Health Economics. - 2007. - № 16 (9). - Р. 924- 944.</mixed-citation><mixed-citation xml:lang="en">Cotoyannis P., Wildman J. Using relative distributions to investigate the body mass index in England and Canada // Health Economics. - 2007. - № 16 (9). - Р. 924- 944.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Cummings D.E., Schwartz M.W. Genetics and pathophysiology of human obesity // Annu Rev Med. - 2003. - № 54. - Р. 453-471.</mixed-citation><mixed-citation xml:lang="en">Cummings D.E., Schwartz M.W. Genetics and pathophysiology of human obesity // Annu Rev Med. - 2003. - № 54. - Р. 453-471.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Diamanti-Kandrakis E., Bourguignon J.P., Giudice L.C. et al. Endocrine-disruption chemicals: an endocrine society scientific statement // Endocr Rev. - 2009. - № 20(4). - Р. 293-342.</mixed-citation><mixed-citation xml:lang="en">Diamanti-Kandrakis E., Bourguignon J.P., Giudice L.C. et al. Endocrine-disruption chemicals: an endocrine society scientific statement // Endocr Rev. - 2009. - № 20(4). - Р. 293-342.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Duhl D.M. et al. Neomorphic agouti mutations in obese yellow mice // Nature. - 1994. - № 8. - Р. 59-65.</mixed-citation><mixed-citation xml:lang="en">Duhl D.M. et al. Neomorphic agouti mutations in obese yellow mice // Nature. - 1994. - № 8. - Р. 59-65.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Edlund M. Designed to last. - 2006. http://www.doctoredlund.com/.</mixed-citation><mixed-citation xml:lang="en">Edlund M. Designed to last. - 2006. http://www.doctoredlund.com/.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Farooqi I.S., O'Rahilly S. Genetics of obesity in humans // Endocr Rev. - 2006. - № 27. - Р. 710-718.</mixed-citation><mixed-citation xml:lang="en">Farooqi I.S., O'Rahilly S. Genetics of obesity in humans // Endocr Rev. - 2006. - № 27. - Р. 710-718.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Flegal K.M., Carroll M.D., Ogden C.L., Johnson C.L. Prevalence and trends in obesity among US adults, 1999-2000 // JAMA. - 2002. - № 288(14). - Р. 1723- 1727.</mixed-citation><mixed-citation xml:lang="en">Flegal K.M., Carroll M.D., Ogden C.L., Johnson C.L. Prevalence and trends in obesity among US adults, 1999-2000 // JAMA. - 2002. - № 288(14). - Р. 1723- 1727.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Fraga M., Ballestar E., Paz M. et al. Epigenetic differences arise during the lifetime of monozygotic twins // PNAS. - 2005. - № 102(30). - Р. 10605-10609.</mixed-citation><mixed-citation xml:lang="en">Fraga M., Ballestar E., Paz M. et al. Epigenetic differences arise during the lifetime of monozygotic twins // PNAS. - 2005. - № 102(30). - Р. 10605-10609.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Froy O. Metabolism and circadian rhythms - implications for obesity // Endocr Rev. - 2009. - № 31(1). - Р. 1-24.</mixed-citation><mixed-citation xml:lang="en">Froy O. Metabolism and circadian rhythms - implications for obesity // Endocr Rev. - 2009. - № 31(1). - Р. 1-24.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Gangwisch J., Heymsfield S. Sleep deprivation as a risk factor for obesity: results based on the NHANES I // North American Association for the Study of Obesity (NAASO). - 2004. - № 42. - A11.</mixed-citation><mixed-citation xml:lang="en">Gangwisch J., Heymsfield S. Sleep deprivation as a risk factor for obesity: results based on the NHANES I // North American Association for the Study of Obesity (NAASO). - 2004. - № 42. - A11.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Garaulet M. Chronobiology and Obesity: The Orchestra Out of Tune // Clin Lipidol. - 2010. - № 5(2). - Р. 181-188</mixed-citation><mixed-citation xml:lang="en">Garaulet M. Chronobiology and Obesity: The Orchestra Out of Tune // Clin Lipidol. - 2010. - № 5(2). - Р. 181-188</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Gluckman P.D., Hanson M.A., Buklijas T. et al. Epigenetic mechanism that underpin metabolic and cardiovascular diseases // Nat Rev Endocrinol. - 2009. - № 5. - Р. 401-408.</mixed-citation><mixed-citation xml:lang="en">Gluckman P.D., Hanson M.A., Buklijas T. et al. Epigenetic mechanism that underpin metabolic and cardiovascular diseases // Nat Rev Endocrinol. - 2009. - № 5. - Р. 401-408.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Grun F., Blumberg B. Endocrine disrupters as obesogens // Mol Cell Endocrinol. - 2009. - № 304. - Р. 19-29.</mixed-citation><mixed-citation xml:lang="en">Grun F., Blumberg B. Endocrine disrupters as obesogens // Mol Cell Endocrinol. - 2009. - № 304. - Р. 19-29.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Hales C.N., Barker D.J. Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis // Diabetologia. - 1992. - № 35. - Р. 595-601.</mixed-citation><mixed-citation xml:lang="en">Hales C.N., Barker D.J. Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis // Diabetologia. - 1992. - № 35. - Р. 595-601.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Heijmansa B.T., Tobia E.W. Steinb A.D.et al. Persistent epigenetic differences associated with prenatal exposure to famine in humans // PNAS. - 2008. - № 105(44). - Р. 17046-17049.</mixed-citation><mixed-citation xml:lang="en">Heijmansa B.T., Tobia E.W. Steinb A.D.et al. Persistent epigenetic differences associated with prenatal exposure to famine in humans // PNAS. - 2008. - № 105(44). - Р. 17046-17049.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">James W.F.T. Epidemiology of obesity // Internat J Obes. - 1992. - № 16(2 suppl). - Р. 23-6.</mixed-citation><mixed-citation xml:lang="en">James W.F.T. Epidemiology of obesity // Internat J Obes. - 1992. - № 16(2 suppl). - Р. 23-6.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Ley R.E., Backhed F., Turnbaugh P. et al. Obesity alters gut microbial ecology // Proc Natl Acad Sci USA. - 2005. - № 102. - Р. 11070-11075.</mixed-citation><mixed-citation xml:lang="en">Ley R.E., Backhed F., Turnbaugh P. et al. Obesity alters gut microbial ecology // Proc Natl Acad Sci USA. - 2005. - № 102. - Р. 11070-11075.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Manco M., Putignani L., Botazzo F. Gut microbiota, llipopolisaharides and innate immunity in the pathogenesis of obesity and cardiovacular risk // Endocr Rev. - 2010. - № 31(6). - Р. 2-64.</mixed-citation><mixed-citation xml:lang="en">Manco M., Putignani L., Botazzo F. Gut microbiota, llipopolisaharides and innate immunity in the pathogenesis of obesity and cardiovacular risk // Endocr Rev. - 2010. - № 31(6). - Р. 2-64.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Martin J.A., Hamilton B.E., Sutton P.D. et al. Births: final data for 2004 // Natl Vital Stat Rep. - 2006. - № 55. - Р. 1-101.</mixed-citation><mixed-citation xml:lang="en">Martin J.A., Hamilton B.E., Sutton P.D. et al. Births: final data for 2004 // Natl Vital Stat Rep. - 2006. - № 55. - Р. 1-101.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Mathews T.J., Hamilton B.E. Mean age of mother, 1970-2000 // Natl Vital Stat Rep. - 2002. - № 51. - Р. 1-13.</mixed-citation><mixed-citation xml:lang="en">Mathews T.J., Hamilton B.E. Mean age of mother, 1970-2000 // Natl Vital Stat Rep. - 2002. - № 51. - Р. 1-13.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Neel J.V. Diabetes mellitus: a "thrifty" genotype rendered detrimental to progress? // Am J Hum Genet. - 1962. - № 14. - Р. 353-62.</mixed-citation><mixed-citation xml:lang="en">Neel J.V. Diabetes mellitus: a "thrifty" genotype rendered detrimental to progress? // Am J Hum Genet. - 1962. - № 14. - Р. 353-62.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Newbold R.R. Impact of environmental endocrine disrupting chemicals on the development of obesity // Hormones. - 2010. - № 9(3). - Р. 206-217.</mixed-citation><mixed-citation xml:lang="en">Newbold R.R. Impact of environmental endocrine disrupting chemicals on the development of obesity // Hormones. - 2010. - № 9(3). - Р. 206-217.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Ogden C.L., Carroll M.D., Curtin L.R. et al. Prevalence of overweight and obesity in the United States, 1999-2004 // JAMA. - 2006. - № 295(13). - Р. 1549-1555.</mixed-citation><mixed-citation xml:lang="en">Ogden C.L., Carroll M.D., Curtin L.R. et al. Prevalence of overweight and obesity in the United States, 1999-2004 // JAMA. - 2006. - № 295(13). - Р. 1549-1555.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Painter R.C., Osmond C., Gluckman P. Transgenerational effects of prenatal exposure to the Dutch famine on neonatal adiposity and health in later life // Int J Ostet Gyn. - 2008. - № 10. - Р. 1243-1249.</mixed-citation><mixed-citation xml:lang="en">Painter R.C., Osmond C., Gluckman P. Transgenerational effects of prenatal exposure to the Dutch famine on neonatal adiposity and health in later life // Int J Ostet Gyn. - 2008. - № 10. - Р. 1243-1249.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Patel S. R., Hu F.B. Short Sleep Duration and Weight Gain: A Systematic Review // Obesity. - 2008. - № 16 (3). - Р. 643-653.</mixed-citation><mixed-citation xml:lang="en">Patel S. R., Hu F.B. Short Sleep Duration and Weight Gain: A Systematic Review // Obesity. - 2008. - № 16 (3). - Р. 643-653.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Patterson M.L., Stern S., Crawford P.B. et al. Sociodemographic factors and obesity in preadolescent black and white girls: NHLBI's Growth and Health Study // J Natl Med Ass. - 1997. - № 89. - Р. 594-600.</mixed-citation><mixed-citation xml:lang="en">Patterson M.L., Stern S., Crawford P.B. et al. Sociodemographic factors and obesity in preadolescent black and white girls: NHLBI's Growth and Health Study // J Natl Med Ass. - 1997. - № 89. - Р. 594-600.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Popkin B. The World is Fat: The Fads, Trends, Policies, and Products That Are Fattening the Human Race. www.cpc.unc.edu.</mixed-citation><mixed-citation xml:lang="en">Popkin B. The World is Fat: The Fads, Trends, Policies, and Products That Are Fattening the Human Race. www.cpc.unc.edu.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Rankinen T., Zuberi A., Chagnon Y. et al. The human obesity gene map: the 2005 update // Obesity. - 2006. - № 14(4). - Р. 529-644.</mixed-citation><mixed-citation xml:lang="en">Rankinen T., Zuberi A., Chagnon Y. et al. The human obesity gene map: the 2005 update // Obesity. - 2006. - № 14(4). - Р. 529-644.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Rothstein M., Cai Y., Marchant G. E. The Ghost in Our Genes: Legal and Ethical Implications of Epigenetics // Health Matrix: Journal of Law-Medicine. - 2009. - № 19 (1). - Р. 2-37.</mixed-citation><mixed-citation xml:lang="en">Rothstein M., Cai Y., Marchant G. E. The Ghost in Our Genes: Legal and Ethical Implications of Epigenetics // Health Matrix: Journal of Law-Medicine. - 2009. - № 19 (1). - Р. 2-37.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Speakman J.R. A nonadaptive scenario explaining predisposition to obesity: the "predation release" hypothesis // Cell Metab. - 2007. - № 6. - Р. 5-12.</mixed-citation><mixed-citation xml:lang="en">Speakman J.R. A nonadaptive scenario explaining predisposition to obesity: the "predation release" hypothesis // Cell Metab. - 2007. - № 6. - Р. 5-12.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Speakman J.R. Thrifty genes for obesity, an attractive but flawed idea, and alternative perspective: the drifty gene hypothesis // Int J Obes. - 2008. - № 32. - Р. 1611-1617.</mixed-citation><mixed-citation xml:lang="en">Speakman J.R. Thrifty genes for obesity, an attractive but flawed idea, and alternative perspective: the drifty gene hypothesis // Int J Obes. - 2008. - № 32. - Р. 1611-1617.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Speakman J.R.,, Djafarian K., Stewart J., Jackson D.M. Assortative mating for obesity // Am J Clin Nutr. - 2007. - № 86. - Р. 316-23.</mixed-citation><mixed-citation xml:lang="en">Speakman J.R.,, Djafarian K., Stewart J., Jackson D.M. Assortative mating for obesity // Am J Clin Nutr. - 2007. - № 86. - Р. 316-23.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Sturm R. Increases in clinically severe obesity in the United States, 1986- 2000 // Arch Intern Med. - 2003. - № 163(18). - Р. 2146-2148.</mixed-citation><mixed-citation xml:lang="en">Sturm R. Increases in clinically severe obesity in the United States, 1986- 2000 // Arch Intern Med. - 2003. - № 163(18). - Р. 2146-2148.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Taylor P.D., Poston L. Developmental programming of obesity in mammals // Experimental Physiology. - 2006. - № 92. - Р. 287-298.</mixed-citation><mixed-citation xml:lang="en">Taylor P.D., Poston L. Developmental programming of obesity in mammals // Experimental Physiology. - 2006. - № 92. - Р. 287-298.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Tsukumo1 D.M., Carvalho D.M., Carvalho-Filho M.A., Saad M. J. Translational research into gut microbiota: new horizons in obesity treatment // Arg Bras Endocrinol Metab. - 2009. - № 53(2). - Р. 139-144.</mixed-citation><mixed-citation xml:lang="en">Tsukumo1 D.M., Carvalho D.M., Carvalho-Filho M.A., Saad M. J. Translational research into gut microbiota: new horizons in obesity treatment // Arg Bras Endocrinol Metab. - 2009. - № 53(2). - Р. 139-144.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Turek F.W., Joshu C., Kohsaka A. et al. Obesity and metabolic syndrome in circadian Clock mutant mice // Science. - 2005. - № 308(5724). - Р. 1043-1045.</mixed-citation><mixed-citation xml:lang="en">Turek F.W., Joshu C., Kohsaka A. et al. Obesity and metabolic syndrome in circadian Clock mutant mice // Science. - 2005. - № 308(5724). - Р. 1043-1045.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Turnbaugh P.J., Ley R.E., Mahowald M.A. et al. An obesity-associated gut microbiome with increased capacity for energy harvest // Nature. - 2006. - № 444. - Р. 1027-1031.</mixed-citation><mixed-citation xml:lang="en">Turnbaugh P.J., Ley R.E., Mahowald M.A. et al. An obesity-associated gut microbiome with increased capacity for energy harvest // Nature. - 2006. - № 444. - Р. 1027-1031.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">van-Vliet-Ostaptchouk J.V., Hofker M.H., Schouw Y.T. et al. Genetic variation in the hypothalamic pathway and its role on obesity // Obes Rev. - 2009. - № 10. - Р. 593-609.</mixed-citation><mixed-citation xml:lang="en">van-Vliet-Ostaptchouk J.V., Hofker M.H., Schouw Y.T. et al. Genetic variation in the hypothalamic pathway and its role on obesity // Obes Rev. - 2009. - № 10. - Р. 593-609.</mixed-citation></citation-alternatives></ref><ref id="cit55"><label>55</label><citation-alternatives><mixed-citation xml:lang="ru">Walley A.J., Asher J.E., Froguel P. The genetic contribution to non-syndromic human obesity // Nat Rev Genetic. - 2009. - № 10. - Р. 431-442.</mixed-citation><mixed-citation xml:lang="en">Walley A.J., Asher J.E., Froguel P. The genetic contribution to non-syndromic human obesity // Nat Rev Genetic. - 2009. - № 10. - Р. 431-442.</mixed-citation></citation-alternatives></ref><ref id="cit56"><label>56</label><citation-alternatives><mixed-citation xml:lang="ru">Wang Y., Beydoun M. A., Liang L. et al. Will all americans become overweight or obese? Estimating the progression and cost of the US obesity epidemic // Obesity. - 2008. - № 16 (10). - Р. 2323-2330.</mixed-citation><mixed-citation xml:lang="en">Wang Y., Beydoun M. A., Liang L. et al. Will all americans become overweight or obese? Estimating the progression and cost of the US obesity epidemic // Obesity. - 2008. - № 16 (10). - Р. 2323-2330.</mixed-citation></citation-alternatives></ref><ref id="cit57"><label>57</label><citation-alternatives><mixed-citation xml:lang="ru">WHO Regional Office for Europe. The challenge of obesity in the WHO European Region and the strategies for response / Ed. Branca F., 2007 http://www.euro.who. int/document/E90711.pdf.</mixed-citation><mixed-citation xml:lang="en">WHO Regional Office for Europe. The challenge of obesity in the WHO European Region and the strategies for response / Ed. Branca F., 2007 http://www.euro.who. int/document/E90711.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit58"><label>58</label><citation-alternatives><mixed-citation xml:lang="ru">Wilkinson P.W., Parkin J.M., Pearlson J. et al. Obesity in childhood: A community study in Newcastle upon Tyne // Lancet. - 1977. - № 1. - Р. 350-352.</mixed-citation><mixed-citation xml:lang="en">Wilkinson P.W., Parkin J.M., Pearlson J. et al. Obesity in childhood: A community study in Newcastle upon Tyne // Lancet. - 1977. - № 1. - Р. 350-352.</mixed-citation></citation-alternatives></ref><ref id="cit59"><label>59</label><citation-alternatives><mixed-citation xml:lang="ru">World Health Organisation. Global Health Risks: mortality and burden of disease attributable to selected major risks (2009). http://www.who.int/healthinfo/global_burden_ disease/global_health_risks/en/index.html.</mixed-citation><mixed-citation xml:lang="en">World Health Organisation. Global Health Risks: mortality and burden of disease attributable to selected major risks (2009). http://www.who.int/healthinfo/global_burden_ disease/global_health_risks/en/index.html.</mixed-citation></citation-alternatives></ref><ref id="cit60"><label>60</label><citation-alternatives><mixed-citation xml:lang="ru">World Health Organization. On behalf of the European Observatory on Health Systems, Observatory Studies Series No 19. Health in the European Union: Trends and Analysis, 2009. http://www.euro.who.int/observatory/Studies/20100201_1.</mixed-citation><mixed-citation xml:lang="en">World Health Organization. On behalf of the European Observatory on Health Systems, Observatory Studies Series No 19. Health in the European Union: Trends and Analysis, 2009. http://www.euro.who.int/observatory/Studies/20100201_1.</mixed-citation></citation-alternatives></ref><ref id="cit61"><label>61</label><citation-alternatives><mixed-citation xml:lang="ru">www.hugenavigator.net.</mixed-citation><mixed-citation xml:lang="en">www.hugenavigator.net.</mixed-citation></citation-alternatives></ref><ref id="cit62"><label>62</label><citation-alternatives><mixed-citation xml:lang="ru">Yang W., Tanika K, He J. Genetic epidemiology of obesity // Epidem Rev 2007. - № 29. - Р. 49-61.</mixed-citation><mixed-citation xml:lang="en">Yang W., Tanika K, He J. Genetic epidemiology of obesity // Epidem Rev 2007. - № 29. - Р. 49-61.</mixed-citation></citation-alternatives></ref><ref id="cit63"><label>63</label><citation-alternatives><mixed-citation xml:lang="ru">Zaninotto P., Head J.,Stamatakis E. Trends in obesity among adults in England from 1993 to 2004 by age and social class and projections of prevalence to 2012 // J Epidemiol Community Health. - 2009. - № 63. - Р. 140-146.</mixed-citation><mixed-citation xml:lang="en">Zaninotto P., Head J.,Stamatakis E. Trends in obesity among adults in England from 1993 to 2004 by age and social class and projections of prevalence to 2012 // J Epidemiol Community Health. - 2009. - № 63. - Р. 140-146.</mixed-citation></citation-alternatives></ref><ref id="cit64"><label>64</label><citation-alternatives><mixed-citation xml:lang="ru">Zimmet P. «Globalization, coca-colonization and the chronic disease epidemic: can the Doomsday scenario be averted?» // J Int Med. - 2000. - № 247. - Р. 17-26.</mixed-citation><mixed-citation xml:lang="en">Zimmet P. «Globalization, coca-colonization and the chronic disease epidemic: can the Doomsday scenario be averted?» // J Int Med. - 2000. - № 247. - Р. 17-26.</mixed-citation></citation-alternatives></ref><ref id="cit65"><label>65</label><citation-alternatives><mixed-citation xml:lang="ru">Zvonic S., Ptitsyn A.A., Conrad S.A. et al. Characterization of peripheral circadian clocks in adipose tissues // Diabetes. - 2006. - № 55. - Р. 962-970.</mixed-citation><mixed-citation xml:lang="en">Zvonic S., Ptitsyn A.A., Conrad S.A. et al. Characterization of peripheral circadian clocks in adipose tissues // Diabetes. - 2006. - № 55. - Р. 962-970.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
