ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/2071-8713-5128ometendo-5128Research ArticleСтатьиArticlesДинамика состояния жировой ткани по данным МР-томографии у больных ожирением на фоне лечения РедуксиномDynamics of adipose tissue changes measured by MRI in obese patients during Reduxin treatmentRomantsovaT Iromantsovatatiana@rambler.ruPoluboyarinovaI Vpolub-irina@mail.ruRoikO Volgaroik@rambler.ru20121512201294№4 (2012)3943Copyright © Romantsova T.I., Poluboyarinova I.V., Roik O.V., 20122012Romantsova T.I., Poluboyarinova I.V., Roik O.V.Romantsova T.I., Poluboyarinova I.V., Roik O.V.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/5128

Цель. Изучить влияние препарата Редуксин у больных ожирением на характер распределения жировой ткани по данным МР-томографии. Методы. В открытое, проспективное, нерандомизированное исследование длительностью 20 недель включен 31 пациент с ожирением в возрасте от 20 до 65 лет. В ходе исследования оценивались антропометрические параметры, а также динамика площади жировой ткани с помощью МР-томографии. Результаты. Снижение массы тела у больных в среднем составило 9,0 кг. Клинически значимого снижения массы тела достигли 23 человека (79%). Медиана снижения окружности талии составила 10 см. Динамическая оценка состояния жировой ткани с помощью МРТ проведена у 17 человек. После окончания лечения Редуксином отмечено статистически значимое уменьшение площади как висцеральной, так и подкожной жировой клетчатки. Вывод. По результатам МР-томографии, уменьшение окружности талии на фоне приема Редуксина происходило за счет уменьшения количества как подкожной, так и висцеральной жировой ткани в абдоминальной области.

Objective. To study the influence of the drug Reduxine in obese patients on the distribution of adipose tissue measured by MRI. Methods. In an open, prospective, non-randomized study duration of 20 weeks included 31 obese patients aged 20 to 65 years. During the study, the anthropometric parameters and the dynamics of the area of adipose tissue by means of MR imaging. Results. Weight loss in patients averaged 9.0 kg. Clinically significant weight loss reached 23 people (79%). Median reduction in waist circumference was 10 cm. Dynamic assessment of adipose tissue by MRI was performed in 17 patients. Reduxine treatment induced statistically significant decrease of both visceral and subcutaneous fat. Conclusions. According to the results of MRI, the reduction in waist circumference in patients receiving Reduxine occurred by reducing the number of both subcutaneous and visceral fat in the abdominal area.

ReferencesDesprés J-P, Lamarche B. Effects of diet and physical activity on adiposity and body fat distribution: implications for the prevention of cardiovascular disease. Nutr Res Rev 1993;6:137–159.Després J-P, Lamarche B. Effects of diet and physical activity on adiposity and body fat distribution: implications for the prevention of cardiovascular disease. Nutr Res Rev 1993;6:137–159.Hunter GR, Snyder SW, Kekes-Szabo T, Nicholson C, Berland I 1994 Intra-abdominal adipose tissue variables associated with risk of possessing elevated blood lipids and blood pressure. Obes Res 2:563–569.Hunter GR, Snyder SW, Kekes-Szabo T, Nicholson C, Berland I 1994 Intra-abdominal adipose tissue variables associated with risk of possessing elevated blood lipids and blood pressure. Obes Res 2:563–569.Van der Kooy K, Seidell JC. Techniques for the measurement of visceral fat: a practical guide. Int J Obes Relat Metab Disord 1993;17:187–196.Van der Kooy K, Seidell JC. Techniques for the measurement of visceral fat: a practical guide. Int J Obes Relat Metab Disord 1993;17:187–196.Matsuzava Y, Funahashi T, Nacamura T. Molecular mechanism of metabolic syndrome X: contribution of adipocyte-derived bioactive substances. Ann N Y Acad Sci 1999;892:146–54.Matsuzava Y, Funahashi T, Nacamura T. Molecular mechanism of metabolic syndrome X: contribution of adipocyte-derived bioactive substances. Ann N Y Acad Sci 1999;892:146–54.Methods for voluntary weight loss and control: NIH Technology Assessment Conference Panel: Consensus Development Conference, 30 March to 1 April, 1992. Ann Intern Med 1993;119:764–770.Methods for voluntary weight loss and control: NIH Technology Assessment Conference Panel: Consensus Development Conference, 30 March to 1 April, 1992. Ann Intern Med 1993;119:764–770.Padwal R, Li SK, Lau DCW. Long-term pharmacotherapy for overweight and obesity: a systematic review and meta-analysis of randomized controlled trials. Int J Obes 2003; 27:1437–1446.Padwal R, Li SK, Lau DCW. Long-term pharmacotherapy for overweight and obesity: a systematic review and meta-analysis of randomized controlled trials. Int J Obes 2003; 27:1437–1446.Park KS, Rhee BD, Lee KU, Kim SY, Lee HK, Koh CS, and Min HK. Intra-abdominal fat is associated with decreased insulin sensitivity in healthy young men. Metabolism 1991;40:600–603.Park KS, Rhee BD, Lee KU, Kim SY, Lee HK, Koh CS, and Min HK. Intra-abdominal fat is associated with decreased insulin sensitivity in healthy young men. Metabolism 1991;40:600–603.Rankinen T, Kim S-Y, Perusse L et al. The prediction of abdominal visceral fat level from body composition and anthropometry: ROC analysis. Int J Obesity 1999;23:801–809.Rankinen T, Kim S-Y, Perusse L et al. The prediction of abdominal visceral fat level from body composition and anthropometry: ROC analysis. Int J Obesity 1999;23:801–809.Ross R, Aru J, Freeman J. et al. Abdominal adiposity and insulin resistance in obese men. Am J Physiol Endocrinol Metab 2002;282:e657–e663.Ross R, Aru J, Freeman J. et al. Abdominal adiposity and insulin resistance in obese men. Am J Physiol Endocrinol Metab 2002;282:e657–e663.Ross R, Freeman J, Hudson R, Janssen I. Abdominal obesity, muscle composition, and insulin resistance in premenopausal women. J Clin Endocrinol Metab 2002;87(11):5044–51.Ross R, Freeman J, Hudson R, Janssen I. Abdominal obesity, muscle composition, and insulin resistance in premenopausal women. J Clin Endocrinol Metab 2002;87(11):5044–51.Ross R, Léger L, Morris DV, de Guise J, and Guardo R. Quantification of adipose tissue by MRI: relationship with anthropometric variables. J Appl Physiol 1992;72:787–795.Ross R, Léger L, Morris DV, de Guise J, and Guardo R. Quantification of adipose tissue by MRI: relationship with anthropometric variables. J Appl Physiol 1992;72:787–795.Wajchenberg BL. Subcutaneous and Visceral Adipose Tissue: Their Relation to the Metabolic Syndrome. Endocr Rev 2000;21(6):697–738.Wajchenberg BL. Subcutaneous and Visceral Adipose Tissue: Their Relation to the Metabolic Syndrome. Endocr Rev 2000;21(6):697–738.Williams MJ, Hunter GR, Kekes-Szabo T, Trueth MS, Snyder S, Berland L, Blaudeau T Intra-abdominal adipose tissue cut-points related to elevated cardiovascular risk in women. Int J Obes 1996;20:613–617.Williams MJ, Hunter GR, Kekes-Szabo T, Trueth MS, Snyder S, Berland L, Blaudeau T Intra-abdominal adipose tissue cut-points related to elevated cardiovascular risk in women. Int J Obes 1996;20:613–617.

The authors declare that there are no conflicts of interest present.