ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/2071-8713-5072ometendo-5072Research ArticleСтатьиArticlesРоль метформина в нейропротекцииThe role of metformin in neuroprotectionDalantaevaN S-201315032013101№1 (2013)4748Copyright © Dalantaeva N.S., 20132013Dalantaeva N.S.Dalantaeva N.S.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/5072ReferencesSpasic MR, Callaerts P, Norga KK: AMP-Activated Protein Kinase (AMPK) Molecular Crossroad for Metabolic Control and Survival of Neurons. Neuroscientist 2009, 15(4):309–316.Spasic MR, Callaerts P, Norga KK: AMP-Activated Protein Kinase (AMPK) Molecular Crossroad for Metabolic Control and Survival of Neurons. Neuroscientist 2009, 15(4):309–316.Culmsee C, Monnig J, Kemp BE, Mattson MP: AMPactivated protein kinase is highly expressed in neurons in the developing rat brain and promotes neuronal survival following glucose deprivation. J Mol Neurosci 2001, 17:45–58.Culmsee C, Monnig J, Kemp BE, Mattson MP: AMPactivated protein kinase is highly expressed in neurons in the developing rat brain and promotes neuronal survival following glucose deprivation. J Mol Neurosci 2001, 17:45–58.Santomauro Júnior AC, Ugolini MR, Santomauro AT, Souto RP: Metformina e AMPK: Um Antigo Fármaco e Uma Nova Enzima no Contexto da Síndrome Metabólica. Arq Bras Endocrinol Metabol 2008, 52(1):120–125.Santomauro Júnior AC, Ugolini MR, Santomauro AT, Souto RP: Metformina e AMPK: Um Antigo Fármaco e Uma Nova Enzima no Contexto da Síndrome Metabólica. Arq Bras Endocrinol Metabol 2008, 52(1):120–125.El-Mir MY, Detaille D, Villanueva G, et al: Neuroprotective Role of Antidiabetic Drug Metformin Against Apoptotic Cell Death in Primary Cortical Neurons. J Mol Neurosci 2008, 34(1):77–87.El-Mir MY, Detaille D, Villanueva G, et al: Neuroprotective Role of Antidiabetic Drug Metformin Against Apoptotic Cell Death in Primary Cortical Neurons. J Mol Neurosci 2008, 34(1):77–87.Andersen JK: Oxidative stress in neurodegeneration: Cause or consequence? Nat Med 2004, 10:S18–S25.Andersen JK: Oxidative stress in neurodegeneration: Cause or consequence? Nat Med 2004, 10:S18–S25.Kroemer G, Reed JC: Mitochondrial control of cell death. Nat Med 2000, 6:513–519.Kroemer G, Reed JC: Mitochondrial control of cell death. Nat Med 2000, 6:513–519.Detaille D, Guigas B, Chauvin C, et al: Metformin prevents high glucose-induced endothelial cell death through a mitochondrial permeability transition-dependent process. Diabetes 2005, 54:2179–2187.Detaille D, Guigas B, Chauvin C, et al: Metformin prevents high glucose-induced endothelial cell death through a mitochondrial permeability transition-dependent process. Diabetes 2005, 54:2179–2187.Plum L, Schubert M, Bruning JC: The role of insulin receptor signaling in the brain. Trends Endocrinol Metab 2005, 16:59–65.Plum L, Schubert M, Bruning JC: The role of insulin receptor signaling in the brain. Trends Endocrinol Metab 2005, 16:59–65.van der Heide LP, Ramakers GM, Smidt MP: Insulin signaling in the central nervous system: learning to survive. Prog Neurobiol 2006, 79:205–221.van der Heide LP, Ramakers GM, Smidt MP: Insulin signaling in the central nervous system: learning to survive. Prog Neurobiol 2006, 79:205–221.Gupta A, Bisht B, Dey CS: Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer’s-like change. Neuropharmacology 2011, 60:910–920.Gupta A, Bisht B, Dey CS: Peripheral insulin-sensitizer drug metformin ameliorates neuronal insulin resistance and Alzheimer’s-like change. Neuropharmacology 2011, 60:910–920.Selkoe DJ: The cell biology of ßamyloid precursor protein and presenilin in Alzheimer’s disease. Trends Cell Biol 1998, 8:447–453.Selkoe DJ: The cell biology of ßamyloid precursor protein and presenilin in Alzheimer’s disease. Trends Cell Biol 1998, 8:447–453.Chen Y, Zhoua K, Wanga R, Liua Y, et al: Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer’s amyloid peptides via up-regulating BACE1 transcription. PNAS 2009, 106(10):3907–3912.Chen Y, Zhoua K, Wanga R, Liua Y, et al: Antidiabetic drug metformin (GlucophageR) increases biogenesis of Alzheimer’s amyloid peptides via up-regulating BACE1 transcription. PNAS 2009, 106(10):3907–3912.Wang J, Gallagher D, De Vito L, et al: Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation. Cell Stem Cell 2012, 11:23–35.Wang J, Gallagher D, De Vito L, et al: Metformin activates an atypical PKC-CBP pathway to promote neurogenesis and enhance spatial memory formation. Cell Stem Cell 2012, 11:23–35.
The authors declare that there are no conflicts of interest present.