ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/2071-8713-5053ometendo-5053Research ArticleСтатьиArticlesВлияние метформина на биодоступность оксида азота у пациентов с сахарным диабетом 2 типаEffect of metformin on the bioavailability of nitric oxide in patients with type 2 diabetesKuznetsovI SISKuznetsov@yandex.ruSerezhenkovV Aserezhenkov@polymer.chph.ras.ruVaninA Fvanin@polymer.chph.ras.ruRomantsovaT Iromantsovatatiana@rambler.ru20121503201291№1 (2012)2933Copyright © Kuznetsov I.S., Serezhenkov V.A., Vanin A.F., Romantsova T.I., 20122012Kuznetsov I.S., Serezhenkov V.A., Vanin A.F., Romantsova T.I.Kuznetsov I.S., Serezhenkov V.A., Vanin A.F., Romantsova T.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/5053

Целью проведенного нами исследования являлась оценка уровня нитритов в плазме и метгемоглобина в цельной крови методом электронного парамагнитного резонанса (ЭПР) у пациентов с сахарным диабетом 2 типа на фоне приема метформина. Через 3 месяца постоянного приема препарата в дозе 1700 мг параллельно с улучшением показателей углеводного и липидного обменов, уменьшением окружности талии отмечалось статистически значимое увеличение концентрации нитрита в плазме и повышение метгемоглобина в цельной крови. Увеличение биодоступности оксида азота на фоне лечения метформином может являться дополнительным объяснением механизма действия препарата

The aim of our study was to evaluate the levels of nitrite in plasma and methemoglobin in whole blood using electron paramagnetic resonance (EPR) in patients with type 2 diabetes mellitus receiving metformin. After 3 months of continuous use of the drug at a dose of 1700 mg in parallel with the improvement of carbohydrate and lipid metabolism, reduction in waist circumference there was a statistically significant increase in nitrite concentration in plasma and increased methemoglobin in whole blood. Increased bioavailability of nitric oxide during treatment with metformin may be an additional explanation for the mechanism of drug action.

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The authors declare that there are no conflicts of interest present.