ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/2071-8713-5049ometendo-5049Research ArticleСтатьиArticlesПерспективы применения селективного модулятора эстрогеновых рецепторов тамоксифена в нейроэндокринологииProspects for the use of selective estrogen receptor modulator tamoxifenBykanovaN Sbykanova@gmail.comPigarovaE Akpigarova@gmail.comDzeranovaL Kmetabol@endocrincentr.ru20121503201291№1 (2012)913Copyright © Bykanova N.S., Pigarova E.A., Dzeranova L.K., 20122012Bykanova N.S., Pigarova E.A., Dzeranova L.K.Bykanova N.S., Pigarova E.A., Dzeranova L.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/5049

В обзоре литературы представлены сведения о применении тамоксифена при различных патологиях головного мозга, механизмах нейропротективного действия селективных модуляторов эстрогеновых рецепторов. Рассмотрены вопросы применения тамоксифена при аденомах гипофиза, в частности, пролактиномах, его влияния на репродуктивную функцию женщин, риск развития осложнений беременности, пороков развития у плода, если у женщины наступила беременность во время приема препарата, а также основания для прекращения терапии тамоксифеном до беременности.

The review presents a contemporary data concerning the use of tamoxifen in wide range of pathological conditions: central nervous system diseases and mechanisms of neuroprotective action of estrogen receptors, pituitary tumors with the accent on the treatment of prolactinomas, infertility treatment. We also discuss the risks of tamoxifen treatment for pregnancy induction in women including complications of pregnancy, fetus malformations.

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The authors declare that there are no conflicts of interest present.