References

ometendo

Ожирение и метаболизм

Obesity and metabolism

2071-87132306-5524

Endocrinology Research Centre

10.14341/2071-8713-4977

ometendo-4977

Research Article

Статьи

Articles

Синдром хронической усталости: современные представления об этиологии

Sindrom khronicheskoy ustalosti: sovremennye predstavleniya ob etiologii

Pigarova

E A

kpigarova@gmail.com

Pleshcheva

A V

nastia040883@yandex.ru

Dzeranova

L K

metabol@endocrincentr.ru

Rozhinskaya

L Ya

rozh@endocrincentr.ru

2010

15092010

№3 (2010)

813

2010

Pigarova E.A., Pleshcheva A.V., Dzeranova L.K., Rozhinskaya L.Y.

Данная работа распространяется под лицензией Creative Commons Attribution 4.0.

This work is licensed under a Creative Commons Attribution 4.0 License.

https://www.omet-endojournals.ru/jour/article/view/4977

Синдром хронической усталости - заболевание, характеризующееся необъяснимым чувством выраженной слабости, длящейся более 6 месяцев. Слабость не проходит даже после длительного отдыха и усиливается после физических или умственных нагрузок. Более 3000 научных исследований доказали, что синдром хронической усталости - не форма депрессии или ипохондрии, а реальное соматическое заболевание, приводящее к профессиональной, социальной и индивидуальной дезадаптации пациентов. В данной статье представлены данные о современных представлениях об этиологии заболевания.

Chronic fatigue syndrome is a disease of unexplained feeling of profound fatigue lasting for more than 6 months. This fatigue is not relieved even after prolonged rest and is exacerbated after physical or mental work. More than 3000 scientific studies had proved that chronic fatigue syndrome is not a form of depression or hypochondria. It is a real somatic illness that results in professional, social and individual desadaptation. This article summarizes the contemporary etiological conceptions of this condition.

синдром хронической усталостислабостьэтиологияиммунитетвирусэндокринология

chronic fatigue syndromeweaknessetiologyimmunityvirusendocrinology

References1

Комаров С.Г. Синдром хронической усталости (распространенность и организация здравоохранения // Автореф. дисс. … к.м.н., Москва, 2008.

Мороз И.Н., Подколзин А.А. // Журнал «Профилактика и старение», Выпуск 1, 1998.

Barhwal K., Hota S.K., Jain V., Prasad D., Singh S.B., Ilavazhagan G. Acetyl-l-carnitine (ALCAR) prevents hypobaric hypoxia-induced spatial memory impairment through extracellular related kinase-mediated nuclear factor erythroid 2-related factor 2 phosphorylation // Neuroscience, 2009, 161 (2): Р. 501-514.

Bennett A.L., Chao C.C., Hu S., Buchwald D., Fagioli L.R., Schur P.H., Peterson P.K., Komaroff A.L. Elevation of bioactive transforming growth factor-beta in serum from patients with chronic fatigue syndrome // J. Clin. Immunol., 1997, Mar; 17(2): Р. 160-166.

Berkovitz S., Ambler G., Jenkins M., Thurgood S. Serum 25-hydroxy vitamin D levels in chronic fatigue syndrome: a retrospective survey // Int. J. Vitam. Nutr. Res., 2009 Jul; 79(4): Р. 250-254.

Bou-Holaigah I., Rowe P.C., Kan J., Calkins H. The relationship between neurally mediated hypotension and the chronic fatigue syndrome // JAMA, 1995, Sep., 27; 274(12): Р. 961-967.

Chiu K.M., Schmidt M.J., Shug A.L., Binkley N., Gravenstein S. Effect of dehydroepiandrosterone sulfate on carnitine acetyl transferase activity and L-carnitine levels in oophorectomized rats // Biochim. Biophys. Acta., 1997, Feb., 18; 1344(3): Р. 201-209.

Chronic Fatigue Syndrome. Centers for Disease Control and Prevention, Alanta, USA (доступно от 07.06.2010 по интернет-ссылке: http://www.cdc.gov/cfs/healthcareprofessionals.htm).

Cleare A.J., Heap E., Malhi G.S., Wessely S., O'Keane V., Miell J. Low-dose hydrocortisone in chronic fatigue syndrome: a randomised crossover trial // Lancet, 1999, Feb., 6; 353(9151): Р. 455-458.

Cleare A.J., O'Keane V., Miell J. Plasma leptin in chronic fatigue syndrome and a placebo-controlled study of the effects of low-dose hydrocortisone on leptin secretion // Clin. Endocrinol. (Oxf). 2001 Jul; 55(1): Р. 113-119.

Cleare A.J., Sookdeo S.S., Jones J., O'Keane V., Miell J.P. Integrity of the growth hormone/insulin-like growth factor system is maintained in patients with chronic fatigue syndrome // J. Clin. Endocrinol. Metab., 2000, Apr; 85(4): Р. 1433-1439.

Cook D.B., Lange G., DeLuca J., Natelson B.H. Relationship of brain MRI abnormalities and physical functional status in chronic fatigue syndrome // Int. J. Neurosci, 2001, Mar; 107(1-2): Р. 1-6.

Demettre E., Bastide L., D'Haese A., De Smet K., De Meirleir K., Tiev K.P., Englebienne P., Lebleu B. Ribonuclease L proteolysis in peripheral blood mononuclear cells of chronic fatigue syndrome patients // J. Biol. Chem., 2002, Sep., 20; 277(38): Р. 35746-51. Epub. 2002 Jul 12.

Demitrack M.A., Dale J.K., Straus S.E., Laue L., Listwak S.J., Kruesi M.J., Chrousos G.P., Gold P.W. Evidence for impaired activation of the hypothalamic-pituitary-adrenal axis in patients with chronic fatigue syndrome // J. Clin. Endocrinol. Metab., 1991, Dec.; 73(6): Р. 1224-1234.

Erlwein O., Kaye S., McClure M.O., Weber J., Willis G., Collier D. et al. Failure to detect the novel retrovirus XMRV in chronic fatigue syndrome // PLoS One 2010; 5: e8519.

Evengеrd B., Briese T., Lindh G., Lee S., Lipkin W.I. Absence of evidence of Borna disease virus infection in Swedish patients with Chronic Fatigue Syndrome // J. Neurovirol., 1999, Oct.; 5(5): P. 495-499.

Fischler B., D'Haenen H., Cluydts R., Michiels V., Demets K., Bossuyt A., Kaufman L., De Meirleir K. Comparison of 99m Tc HMPAO SPECT scan between chronic fatigue syndrome, major depression and healthy controls: an exploratory study of clinical correlates of regional cerebral blood flow // Neuropsychobiology, 1996; 34(4): Р. 175-183.

Fukuda K., Straus S.E., Hickie I., Sharpe M.C., Dobbins J.G., Komaroff A. The chronic fatigue syndrome: a comprehensive approach to its definition and study // Ann. Int. Med., 1994, 121: Р. 953-959.

Gaab J., Engert V., Heitz V., Schad T., Schьrmeyer T.H., Ehlert U. Associations between neuroendocrine responses to the Insulin Tolerance Test and patient characteristics in chronic fatigue syndrome // J. Psychosom. Res., 2004, Apr; 56(4): Р. 419-424.

Gaab J., Hьster D., Peisen R., Engert V., Schad T., Schьrmeyer T.H., Ehlert U. Low-dose dexamethasone suppression test in chronic fatigue syndrome and health // Psychosom. Med., 2002, Mar.-Apr.; 64(2): Р. 311-318.

Groom H.C., Boucherit V.C., Makinson K., Randal E., Baptista S., Hagan S., Gow J.W., Mattes F.M., Breuer J., Kerr J.R., Stoye J.P., Bishop K.N. Absence of xenotropic murine leukaemia virus-related virus in UK patients with chronic fatigue syndrome // Retrovirology, 2010, Feb., 15; 7: Р. 10.

Himmel P.B., Seligman T.M. A pilot study employing Dehydroepiandrosterone (DHEA) in the treatment of chronic fatigue syndrome // J. Clin. Rheumatol., 1999, Apr.; 5(2): Р. 56-59.

Ichise M., Salit I.E., Abbey S.E., Chung D.G., Gray B., Kirsh J.C., Freedman M. Assessment of regional cerebral perfusion by 99Tcm-HMPAO SPECT in chronic fatigue syndrome // Nucl. Med. Commun., 1992, Oct.; 13(10): Р. 767-772.

Ikuta K., Yamada T., Shimomura T., Kuratsune H., Kawahara R., Ikawa S., Ohnishi E., Sokawa Y., Fukushi H., Hirai K., Watanabe Y., Kurata T., Kitani T., Sairenji T. Diagnostic evaluation of 2',5'-oligoadenylate synthetase activities and antibodies against Epstein-Barr virus and Coxiella burnetii in patients with chronic fatigue syndrome in Japan // Microbes Infect. 2003, Oct.; 5(12): Р. 1096-1102.

Inoue K., Yamazaki H., Manabe Y., Fukuda C., Hanai K., Fushiki T. Transforming growth factor-beta activated during exercise in brain depresses spontaneous motor activity of animals. Relevance To central fatigue // Brain Res. 1999, Nov., 6; 846(2): Р. 145-153.

Jason L.A., Richman J.A., Rademaker A.W., Jordan K.M., Plioplys A.V., Taylor R.R., McCready W., Huan C.F., Plioplys S. A community-based study of chronic fatigue syndrome // Arch. Int. Med., 1999, 159: Р. 2129-2137.

Jason L.A., Taylor R.R., Kennedy C.L., Jordan K., Song S., Johnson D.E., Torres S.R. Chronic fatigue syndrome: sociodemographic subtypes in a community- based sample // Eval Health Profess., 2000, 23 (3): Р. 243-263.

Katafuchi T., Kondo T., Yasaka T., Kubo K., Take S., Yoshimura M. Prolonged effects of polyriboinosinic:polyribocytidylic acid on spontaneous running wheel activity and brain interferon-alpha mRNA in rats: a model for immunologically induced fatigue // Neuroscience. 2003; 120(3): Р. 837-845.

Klimas N.G., Salvato F.R., Morgan R., Fletcher M.A. Immunologic abnormalities in chronic fatigue syndrome // J. Clin. Microbiol., 1990, Jun; 28(6): Р. 1403-1410.

Knook L., Kavelaars A., Sinnema G., Kuis W., Heijnen C.J. High nocturnal melatonin in adolescents with chronic fatigue syndrome // J. Clin. Endocrinol. Metab., 2000, Oct.; 85(10): Р. 3690-3692.

Kuratsune H., Yamaguti K., Lindh G., Evengеrd B., Hagberg G., Matsumura K., Iwase M., Onoe H., Takahashi M., Machii T., Kanakura Y., Kitani T., Lеngstrцm B., Watanabe Y. Brain regions involved in fatigue sensation: reduced acetylcarnitine uptake into the brain // Neuroimage, 2002, Nov.; 17(3): Р. 1256-1265.

Kuratsune H., Yamaguti K., Sawada M., Kodate S., Machii T., Kanakura Y., Kitani T. Dehydroepiandrosterone sulfate deficiency in chronic fatigue syndrome // Int. J. Mol. Med., 1998, Jan.; 1(1): Р. 143-146.

Lerner A.M., Beqaj S.H., Deeter R.G., Fitzgerald J.T. IgM serum antibodies to Epstein-Barr virus are uniquely present in a subset of patients with the chronic fatigue syndrome // In Vivo. 2004, Mar.-Apr.; 18(2): Р. 101-106.

Li Y.J., Wang D.X., Bai X.L., Chen J., Liu Z.D., Feng Z.J., Zhao Y.M. Clinical characteristics of patients with chronic fatigue syndrome: analysis of 82 cases // Zhonghua Yi Xue Za Zhi. 2005 Mar., 16; 85(10): Р. 701-704.

Li Y.J., Wang D.X., Zhang F.M., Liu Z.D., Yang A.Y., Ykuta K. Detection of antibody against Borna disease virus-p24 in the plasma of Chinese patients with chronic fatigue syndrome by Western-blot analysis // Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 2003, Dec.; 17(4): Р. 330-333.

Lombardi V.C., Ruscetti F.W., Das Gupta J., Pfost M.A., Hagen K.S., Peterson D.L., Ruscetti S.K., Bagni R.K., Petrow-Sadowski C., Gold B., Dean M., Silverman R.H., Mikovits J.A. Detection of an infectious retrovirus, XMRV, in blood cells of patients with chronic fatigue syndrome // Science. 2009, Oct., 23; 326(5952): Р. 585-589.

McKenzie R., O'Fallon A., Dale J., Demitrack M., Sharma G., Deloria M., Garcia-Borreguero D., Blackwelder W., Straus S.E. Low-dose hydrocortisone for treatment of chronic fatigue syndrome: a randomized controlled trial // JAMA. 1998, Sep., 23-30; 280(12): Р. 1061-1066.

Moorkens G., Berwaerts J., Wynants H., Abs R. Characterization of pituitary function with emphasis on GH secretion in the chronic fatigue syndrome // Clin. Endocrinol. (Oxf). 2000, Jul; 53(1): Р. 99-106.

Moorkens G., Wynants H., Abs R. Effect of growth hormone treatment in patients with chronic fatigue syndrome: a preliminary study // Growth. Horm. IGF Res. 1998, Apr; 8 Suppl B: Р. 131-133.

Moss R.B., Mercandetti A., Vojdani A. TNF-alpha and chronic fatigue syndrome // J. Clin. Immunol. 1999, Sep; 19(5): Р. 314-316.

Natelson B.H., Cohen J.M., Brassloff I., Lee H.J. A controlled study of brain magnetic resonance imaging in patients with the chronic fatigue syndrome // J. Neurol. Sci. 1993, Dec., 15; 120(2): Р. 213-217.

Parker A.J., Wessely S., Cleare A.J. The neuroendocrinology of chronic fatigue syndrome and fibromyalgia // Psychol. Med., 2001, Nov.; 31(8): Р. 1331-1345.

Peterson P.K., Pheley A., Schroeppel J., Schenck C., Marshall P., Kind A., Haugland J.M., Lambrecht L.J., Swan S., Goldsmith S. A preliminary placebo-controlled crossover trial of fludrocortisone for chronic fatigue syndrome // Arch. Intern. Med. 1998, Apr., 27; 158(8): Р. 908-914.

Rebouche C.J., Paulson D.J. Carnitine metabolism and function in humans // Annu. Rev. Nutr. 1986; 6: Р. 41-66.

Reeves W.C., Jones J.F., Maloney E., Heim C., Hoaglin D.C., Boneva R., Morrissey M., Devlin R. Prevalence of chronic fatigue syndrome in metropolitan, urban, and rural Georgia // Population Health Metrics 2007, 8 (5): Р. 5.

Reeves W.C., Lloyd A., Vernon S.D., Klimas N., Jason L.A., Bleijenberg G., Evengard B., White P.D., Nisenbaum R., Unger E.R. Identification of ambiguities n the 1994 chronic fatigue syndrome research case definition and recommendations for resolution // BMC Health Services Research 2003, 3: Р. 25.

Reyes M., Nisenbaum R., Hoaglin D.C., Emmons C., Stewart G., Randall B., Stewart J.A., Abbey S., Jones J.F., Gantz N., Minden S., Reeves W.C. Prevalence and incidence of chronic fatigue syndrome in Wichita, Kansas // Arch. Intern. Med. 2003, 163: Р. 1530-1536.

Roberts A.D., Wessely S., Chalder T., Papadopoulos A., Cleare A.J. Salivary cortisol response to awakening in chronic fatigue syndrome // Br. J. Psychiatry. 2004, Feb.; 184: Р. 136-141.

Rowe P.C., Calkins H., DeBusk K., McKenzie R., Anand R., Sharma G., Cuccherini B.A., Soto N., Hohman P., Snader S., Lucas K.E., Wolff M., Straus S.E. Fludrocortisone acetate to treat neurally mediated hypotension in chronic fatigue syndrome: a randomized controlled trial // JAMA. 2001, Jan., 3; 285(1): Р. 52-59.

Stankovic A.K., Dion L.D., Parker C.R. Jr. Effects of transforming growth factorbeta on human fetal adrenal steroid production // Mol. Cell. Endocrinol., 1994, Mar.; 99(2): Р. 145-151.

Suhadolnik R.J., Reichenbach N.L., Hitzges P., Sobol R.W., Peterson D.L., Henry B., Ablashi D.V., Mьller W.E., Schrцder H.C., Carter W.A. et al. Upregulation of the 2-5A synthetase/RNase L antiviral pathway associated with chronic fatigue syndrome // Clin. Infect. Dis. 1994, Jan.; 18 Suppl 1:S96-104.

Tanaka S., Kuratsune H., Hidaka Y., Hakariya Y., Tatsumi K.I., Takano T., Kanakura Y., Amino N. Autoantibodies against muscarinic cholinergic receptor in chronic fatigue syndrome // Int. J. Mol. Med. 2003, Aug.; 12(2): Р. 225-230.

Tirelli U., Chierichetti F., Tavio M., Simonelli C., Bianchin G., Zanco P., Ferlin G. Brain positron emission tomography (PET) in chronic fatigue syndrome: preliminary data // Am. J. Med. 1998 Sep., 28; 105(3A): Р. 54S-58S.

Van Kuppeveld F.J.M., de Jong A.S., Lanke K.H., Verhaegh G.W., Melchers W.J.G., Swanink C.M.A. et al. Prevalence of xenotropic murine leukaemia virus-related virus in patients with chronic fatigue syndrome in the Netherlands: retrospective analysis of samples from an established cohort // BMJ, 2010; 340: c1018.

Vermeulen R.C., Scholte H.R. Azithromycin in chronic fatigue syndrome (CFS), an analysis of clinical data // J. Transl. Med. 2006 Aug., 15; 4: 34.

Vermeulen R.C., Scholte H.R. Exploratory open label, randomized study of acetyl- and propionylcarnitine in chronic fatigue syndrome // Psychosom. Med. 2004, Mar.-Apr.; 66(2): Р. 276-282.

Yamamoto S., Ouchi Y., Onoe H., Yoshikawa E., Tsukada H., Takahashi H., Iwase M., Yamaguti K., Kuratsune H., Watanabe Y. Reduction of serotonin transporters of patients with chronic fatigue syndrome // Neuroreport. 2004. Dec., 3; 15(17): Р. 2571-2574.

The authors declare that there are no conflicts of interest present.