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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ometendo</journal-id><journal-title-group><journal-title xml:lang="ru">Ожирение и метаболизм</journal-title><trans-title-group xml:lang="en"><trans-title>Obesity and metabolism</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2071-8713</issn><issn pub-type="epub">2306-5524</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/2071-8713-4970</article-id><article-id custom-type="elpub" pub-id-type="custom">ometendo-4970</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Новые возможности в лечении и ведении акромегалии</article-title><trans-title-group xml:lang="en"><trans-title>New opportunities in the treatment and management of acromegaly</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Dalantaeva</surname><given-names>N S</given-names></name></name-alternatives><bio xml:lang="ru"><p>аспирант отделения нейроэндокринологии и остеопатий</p></bio><email xlink:type="simple">nsdalantaeva@gmail.com</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Pigarova</surname><given-names>E A</given-names></name></name-alternatives><bio xml:lang="ru"><p>к.м.н., ст.н.с. отделения нейроэндокринологии и остеопатий</p></bio><email xlink:type="simple">kpigarova@gmail.com</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Dzeranova</surname><given-names>L K</given-names></name></name-alternatives><bio xml:lang="ru"><p>д.м.н., гл.н.с. отделения нейроэндокринологии и остеопатий</p></bio><email xlink:type="simple">metabol@endocrincentr.ru</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Rozhinskaya</surname><given-names>L Ya</given-names></name></name-alternatives><bio xml:lang="ru"><p>проф., д.м.н., зав. отделением нейроэндокринологии и остеопатий</p></bio><email xlink:type="simple">-</email></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Dedov</surname><given-names>I I</given-names></name></name-alternatives><bio xml:lang="ru"><p>директор ФГБУ Эндокринологический научный центр Минздравсоцразвития</p></bio><email xlink:type="simple">dedov@endocrincentr.ru</email></contrib></contrib-group><pub-date pub-type="collection"><year>2012</year></pub-date><pub-date pub-type="epub"><day>15</day><month>09</month><year>2012</year></pub-date><volume>9</volume><issue>3</issue><issue-title>№3 (2012)</issue-title><fpage>29</fpage><lpage>32</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Dalantaeva N.S., Pigarova E.A., Dzeranova L.K., Rozhinskaya L.Y., Dedov I.I., 2012</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="ru">Dalantaeva N.S., Pigarova E.A., Dzeranova L.K., Rozhinskaya L.Y., Dedov I.I.</copyright-holder><copyright-holder xml:lang="en">Dalantaeva N.S., Pigarova E.A., Dzeranova L.K., Rozhinskaya L.Y., Dedov I.I.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.omet-endojournals.ru/jour/article/view/4970">https://www.omet-endojournals.ru/jour/article/view/4970</self-uri><abstract><p>Генетические аспекты семейных изолированных аденом гипофиза (FIPA) стремительно расширяются в течение последних нескольких лет. Обнаружено, что около 20% этих семей FIPA имеют мутации в гене AIP, кодирующем белок арилуглеводородного рецептора. Количество выявленных AIP-положительных FIPA семей растет во всем мире.</p></abstract><trans-abstract xml:lang="en"><p>Genetic aspects of familial isolated pituitary adenomas (FIPA) are expanding rapidly in the last few years. Around 20% of these FIPA families have been identified to have mutations within the aryl hydrocarbon receptor interacting protein (AIP) gene. The number of identified AIP-positive FIPA families is increasing all over the world.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>аденомы гипофиза</kwd></kwd-group><kwd-group xml:lang="en"><kwd>AIP</kwd><kwd>FIPA</kwd><kwd>pituitary adenomas</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Ayuk J, Clayton RN, Holder G, et al. 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