<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">ometendo</journal-id><journal-title-group><journal-title xml:lang="ru">Ожирение и метаболизм</journal-title><trans-title-group xml:lang="en"><trans-title>Obesity and metabolism</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">2071-8713</issn><issn pub-type="epub">2306-5524</issn><publisher><publisher-name>Endocrinology Research Centre</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.14341/2071-8713-4941</article-id><article-id custom-type="elpub" pub-id-type="custom">ometendo-4941</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>Articles</subject></subj-group></article-categories><title-group><article-title>Ожирение и онкологические заболевания: старая проблема в новом свете</article-title><trans-title-group xml:lang="en"><trans-title>Ozhirenie i onkologicheskie zabolevaniya: staraya problema v novom svete</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Берштейн</surname><given-names>Леонид Михайлович</given-names></name><name name-style="western" xml:lang="en"><surname>Bershteyn</surname><given-names>L M</given-names></name></name-alternatives><email xlink:type="simple">omet@endojournals.ru</email></contrib></contrib-group><pub-date pub-type="collection"><year>2006</year></pub-date><pub-date pub-type="epub"><day>15</day><month>03</month><year>2006</year></pub-date><volume>3</volume><issue>1</issue><issue-title>№1 (2006)</issue-title><fpage>42</fpage><lpage>47</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Берштейн Л.М., 2006</copyright-statement><copyright-year>2006</copyright-year><copyright-holder xml:lang="ru">Берштейн Л.М.</copyright-holder><copyright-holder xml:lang="en">Bershteyn L.M.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://www.omet-endojournals.ru/jour/article/view/4941">https://www.omet-endojournals.ru/jour/article/view/4941</self-uri><abstract><p>.</p></abstract><trans-abstract xml:lang="en"><p>.</p></trans-abstract></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Berstein L.M. Macrosomy, obesity and cancer. New York: Nova Sci. Publ., 1997. 195 p.</mixed-citation><mixed-citation xml:lang="en">Berstein L.M. Macrosomy, obesity and cancer. New York: Nova Sci. Publ., 1997. 195 p.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Берштейн Л.М. Внегонадная продукция эстрогенов (роль в физиологии и патологии). СПб.: Наука, 1998. 172 с.</mixed-citation><mixed-citation xml:lang="en">Берштейн Л.М. Внегонадная продукция эстрогенов (роль в физиологии и патологии). СПб.: Наука, 1998. 172 с.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Берштейн Л.М. Онкоэндокринология:традиции, современность и перспективы. СПб.: Наука, 2004. 343 с.</mixed-citation><mixed-citation xml:lang="en">Берштейн Л.М. Онкоэндокринология:традиции, современность и перспективы. СПб.: Наука, 2004. 343 с.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Berstein L.M. Clinical usage of hypolipidemic and antidiabetic drugs in the prevention and treatment of cancer. Cancer Lett. 2005;224:203-212.</mixed-citation><mixed-citation xml:lang="en">Berstein L.M. Clinical usage of hypolipidemic and antidiabetic drugs in the prevention and treatment of cancer. Cancer Lett. 2005;224:203-212.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Берштейн Л.М. Гормоны жировой ткани (адипоцитокины): онтогенетический и онкологический аспект проблемы. // Усп. геронтол. 2005. Вып. 16. С. 51-64.</mixed-citation><mixed-citation xml:lang="en">Берштейн Л.М. Гормоны жировой ткани (адипоцитокины): онтогенетический и онкологический аспект проблемы. // Усп. геронтол. 2005. Вып. 16. С. 51-64.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Дедов И.И., Мельниченко Г.А. (ред.). Ожирение. М.: МИА, 2004.</mixed-citation><mixed-citation xml:lang="en">Дедов И.И., Мельниченко Г.А. (ред.). Ожирение. М.: МИА, 2004.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Дедов И.И., Мельниченко Г.А., Фадеев В.В. Эндокринология. М.: Медицина, 2000. 631 с.</mixed-citation><mixed-citation xml:lang="en">Дедов И.И., Мельниченко Г.А., Фадеев В.В. Эндокринология. М.: Медицина, 2000. 631 с.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Дильман В.М. Четыре модели медицины. Л.: Медицина, 1987. 287 с.</mixed-citation><mixed-citation xml:lang="en">Дильман В.М. Четыре модели медицины. Л.: Медицина, 1987. 287 с.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Семиглазов В.Ф., Нургазиев К.Ш., Арзуманов А.С. Опухоли молочной железы (лечение и профилактика). Алмааты, 2001. 344 с.</mixed-citation><mixed-citation xml:lang="en">Семиглазов В.Ф., Нургазиев К.Ш., Арзуманов А.С. Опухоли молочной железы (лечение и профилактика). Алмааты, 2001. 344 с.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Adami H.-O., Signorello L.B., Trichopoulos D. Towards an understanding of breast cancer etiology.Semin. Cancer Biol. 1998;8:255-262.</mixed-citation><mixed-citation xml:lang="en">Adami H.-O., Signorello L.B., Trichopoulos D. Towards an understanding of breast cancer etiology.Semin. Cancer Biol. 1998;8:255-262.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Ballard-Barbash R., Swanson C.A. Body weight: estimation of risk for breast and endometrial cancers. Am. J. Clin. Nutr.1996;63 (Suppl. 3):437-441.</mixed-citation><mixed-citation xml:lang="en">Ballard-Barbash R., Swanson C.A. Body weight: estimation of risk for breast and endometrial cancers. Am. J. Clin. Nutr.1996;63 (Suppl. 3):437-441.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">Boyd N.F., Cousins M., Lockwood C, Trichler D. Dietary fat and breast cancer risk. The feasibility of a clinical trial of breast cancer prevention. Lipids. 1992;27:821-827.</mixed-citation><mixed-citation xml:lang="en">Boyd N.F., Cousins M., Lockwood C, Trichler D. Dietary fat and breast cancer risk. The feasibility of a clinical trial of breast cancer prevention. Lipids. 1992;27:821-827.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">Brakenhielm E., Veitonmaki N., Cao R. et al. Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis. Proc. Natl. Acad. Sci. (USA). 2004;101:2476-2481.</mixed-citation><mixed-citation xml:lang="en">Brakenhielm E., Veitonmaki N., Cao R. et al. Adiponectin-induced antiangiogenesis and antitumor activity involve caspase-mediated endothelial cell apoptosis. Proc. Natl. Acad. Sci. (USA). 2004;101:2476-2481.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Calle E.E., Rodriguez C, Walker-Thurmond K., Thun M.J. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. New Engl. J. Med. 2003;348:1625-1638.</mixed-citation><mixed-citation xml:lang="en">Calle E.E., Rodriguez C, Walker-Thurmond K., Thun M.J. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. New Engl. J. Med. 2003;348:1625-1638.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Catalano S., Mauro L, Marsico S. et al. Leptin induces, via ERK1/ERK2 signal, functional activation of estrogen receptor alpha in MCF-7 cells. J. Biol. Chem. 2004;279:19908-19915.</mixed-citation><mixed-citation xml:lang="en">Catalano S., Mauro L, Marsico S. et al. Leptin induces, via ERK1/ERK2 signal, functional activation of estrogen receptor alpha in MCF-7 cells. J. Biol. Chem. 2004;279:19908-19915.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Chlebowski R.T., Stefanick M.l., McTiernan A. et al. Dietary Fat Reduction in Postmenopausal Women with Primary Breast Cancer: Phase III Women's Intervention Nutrition Study (WINS). ASCO Proceed. 2005.</mixed-citation><mixed-citation xml:lang="en">Chlebowski R.T., Stefanick M.l., McTiernan A. et al. Dietary Fat Reduction in Postmenopausal Women with Primary Breast Cancer: Phase III Women's Intervention Nutrition Study (WINS). ASCO Proceed. 2005.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Facchini F.S., Hua N., Abbasi F., Reaven G.M. Insulin resistance as a predictor of age-related diseases. J. Clin. Endocrinol. Metab. 2001;86:3574-3578.</mixed-citation><mixed-citation xml:lang="en">Facchini F.S., Hua N., Abbasi F., Reaven G.M. Insulin resistance as a predictor of age-related diseases. J. Clin. Endocrinol. Metab. 2001;86:3574-3578.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Fain J.N., Madan A.K., Hiler M.l. et al. Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans. Endocrinology. 2004;145:2273-2282.</mixed-citation><mixed-citation xml:lang="en">Fain J.N., Madan A.K., Hiler M.l. et al. Comparison of the release of adipokines by adipose tissue, adipose tissue matrix, and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans. Endocrinology. 2004;145:2273-2282.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Fernandez-Real J.M., Ricart W. Insulin resistance and chronic cardiovascular inflammatory syndrome. Endocrine Rev. 2003;24:278-301.</mixed-citation><mixed-citation xml:lang="en">Fernandez-Real J.M., Ricart W. Insulin resistance and chronic cardiovascular inflammatory syndrome. Endocrine Rev. 2003;24:278-301.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Forbes G.B. Human body composition. Growth, aging, nutrition and activity. NY-Berlin-Heidelberg: Springer-Verlag, 1987. 350 p.</mixed-citation><mixed-citation xml:lang="en">Forbes G.B. Human body composition. Growth, aging, nutrition and activity. NY-Berlin-Heidelberg: Springer-Verlag, 1987. 350 p.</mixed-citation></citation-alternatives></ref><ref id="cit21"><label>21</label><citation-alternatives><mixed-citation xml:lang="ru">Fruehwald-Schultes В., Oltmanns K.M., Toschek B. et al. Short-term treatment with metformin decreases serum leptin concentration without affecting body weight and body fat content in normal-weight healthy men. Metabolism. 2002;51:531-536.</mixed-citation><mixed-citation xml:lang="en">Fruehwald-Schultes В., Oltmanns K.M., Toschek B. et al. Short-term treatment with metformin decreases serum leptin concentration without affecting body weight and body fat content in normal-weight healthy men. Metabolism. 2002;51:531-536.</mixed-citation></citation-alternatives></ref><ref id="cit22"><label>22</label><citation-alternatives><mixed-citation xml:lang="ru">Fukuhara A., Matsuda M., Nishizawa M. et al. Visfatin:a protein secreted by visceral fat that mimics the effects of insulin. Science. 2005;307:426-430.</mixed-citation><mixed-citation xml:lang="en">Fukuhara A., Matsuda M., Nishizawa M. et al. Visfatin:a protein secreted by visceral fat that mimics the effects of insulin. Science. 2005;307:426-430.</mixed-citation></citation-alternatives></ref><ref id="cit23"><label>23</label><citation-alternatives><mixed-citation xml:lang="ru">Furukawa S., Fujita Т., Shimabukuro M. et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J. Clin. Invest. 2004;114:1752-1761.</mixed-citation><mixed-citation xml:lang="en">Furukawa S., Fujita Т., Shimabukuro M. et al. Increased oxidative stress in obesity and its impact on metabolic syndrome. J. Clin. Invest. 2004;114:1752-1761.</mixed-citation></citation-alternatives></ref><ref id="cit24"><label>24</label><citation-alternatives><mixed-citation xml:lang="ru">Henderson B.E., Feigelson H.S. Hormonal carcinogenesis. Carcinogenesis. 2000;21:427-433.</mixed-citation><mixed-citation xml:lang="en">Henderson B.E., Feigelson H.S. Hormonal carcinogenesis. Carcinogenesis. 2000;21:427-433.</mixed-citation></citation-alternatives></ref><ref id="cit25"><label>25</label><citation-alternatives><mixed-citation xml:lang="ru">Hovey R.C., McFadden T.B., Akers R.M. Regulation of mammary gland growth and morphogenesis by the mammary fat pad: a species comparison. J. Mammary Gland Biol. Neoplasia. 1999;4:53-68.</mixed-citation><mixed-citation xml:lang="en">Hovey R.C., McFadden T.B., Akers R.M. Regulation of mammary gland growth and morphogenesis by the mammary fat pad: a species comparison. J. Mammary Gland Biol. Neoplasia. 1999;4:53-68.</mixed-citation></citation-alternatives></ref><ref id="cit26"><label>26</label><citation-alternatives><mixed-citation xml:lang="ru">Iyengar P., Combs T:, Shah S.J. et al. Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization. Oncogene. 2003;22:6408-6423.</mixed-citation><mixed-citation xml:lang="en">Iyengar P., Combs T:, Shah S.J. et al. Adipocyte-secreted factors synergistically promote mammary tumorigenesis through induction of anti-apoptotic transcriptional programs and proto-oncogene stabilization. Oncogene. 2003;22:6408-6423.</mixed-citation></citation-alternatives></ref><ref id="cit27"><label>27</label><citation-alternatives><mixed-citation xml:lang="ru">Kaaks R, Berrino F, Key T. et al. Serum sex steroids in premenopausal women and breast cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC). J. Natl. Cancer Inst. 2005;97:755-765.</mixed-citation><mixed-citation xml:lang="en">Kaaks R, Berrino F, Key T. et al. Serum sex steroids in premenopausal women and breast cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC). J. Natl. Cancer Inst. 2005;97:755-765.</mixed-citation></citation-alternatives></ref><ref id="cit28"><label>28</label><citation-alternatives><mixed-citation xml:lang="ru">Kershaw E.E., Flier J.S. Adipose tissue as an endocrine organ. J. Clin. Endocrinol. Metabol. 2004;89:2548-2556.</mixed-citation><mixed-citation xml:lang="en">Kershaw E.E., Flier J.S. Adipose tissue as an endocrine organ. J. Clin. Endocrinol. Metabol. 2004;89:2548-2556.</mixed-citation></citation-alternatives></ref><ref id="cit29"><label>29</label><citation-alternatives><mixed-citation xml:lang="ru">Kroenke C.H., Chen W.Y., Rosner В., Holmes M.D. Weight, weight gain, and survival after breast cancer diagnosis. J. Clin. Oncol. 2005;23:1370-1378.</mixed-citation><mixed-citation xml:lang="en">Kroenke C.H., Chen W.Y., Rosner В., Holmes M.D. Weight, weight gain, and survival after breast cancer diagnosis. J. Clin. Oncol. 2005;23:1370-1378.</mixed-citation></citation-alternatives></ref><ref id="cit30"><label>30</label><citation-alternatives><mixed-citation xml:lang="ru">Lawlor DA, Smith GD, Ebrahim S. Hyperinsulinaemia and increased risk of breast cancer:findings from the British Women's Heart and Health Study. Cancer Causes Control. 2004;15:267-275.</mixed-citation><mixed-citation xml:lang="en">Lawlor DA, Smith GD, Ebrahim S. Hyperinsulinaemia and increased risk of breast cancer:findings from the British Women's Heart and Health Study. Cancer Causes Control. 2004;15:267-275.</mixed-citation></citation-alternatives></ref><ref id="cit31"><label>31</label><citation-alternatives><mixed-citation xml:lang="ru">Levine J.A., Lanningham-Foster L.M., McCrady S.K. et al. Interindividual variation in human posture allocation: possible role in human obesity. Science. 2005;307:584-586.</mixed-citation><mixed-citation xml:lang="en">Levine J.A., Lanningham-Foster L.M., McCrady S.K. et al. Interindividual variation in human posture allocation: possible role in human obesity. Science. 2005;307:584-586.</mixed-citation></citation-alternatives></ref><ref id="cit32"><label>32</label><citation-alternatives><mixed-citation xml:lang="ru">Lew E.A., Garfinkel L. Variations in mortality by weight among 750 000 men and women. J. Chron. Dis.1979;32:563-576.</mixed-citation><mixed-citation xml:lang="en">Lew E.A., Garfinkel L. Variations in mortality by weight among 750 000 men and women. J. Chron. Dis.1979;32:563-576.</mixed-citation></citation-alternatives></ref><ref id="cit33"><label>33</label><citation-alternatives><mixed-citation xml:lang="ru">Mantzoros C, Petridou E., Dessypris N. et al. Adiponectin and breast cancer risk. J. Clin. Endocrinol. Metabol. 2004;89:1102-1107.</mixed-citation><mixed-citation xml:lang="en">Mantzoros C, Petridou E., Dessypris N. et al. Adiponectin and breast cancer risk. J. Clin. Endocrinol. Metabol. 2004;89:1102-1107.</mixed-citation></citation-alternatives></ref><ref id="cit34"><label>34</label><citation-alternatives><mixed-citation xml:lang="ru">Matsuzawa Y., Shimomura I., Kihara S., Funahashi T. Importance of adipocytokines in insulin resistance and obesity-related diseases. Horm. Res. 2003;60(Suppl. 3):56-59.</mixed-citation><mixed-citation xml:lang="en">Matsuzawa Y., Shimomura I., Kihara S., Funahashi T. Importance of adipocytokines in insulin resistance and obesity-related diseases. Horm. Res. 2003;60(Suppl. 3):56-59.</mixed-citation></citation-alternatives></ref><ref id="cit35"><label>35</label><citation-alternatives><mixed-citation xml:lang="ru">Matsuzawa Y., Funahashi Т., Kihara S., Shimomura I. Adiponectin and metabolic syndrome. Arterioscler. Thromb. Vase. Biol. Med. 2004;24:29-34.</mixed-citation><mixed-citation xml:lang="en">Matsuzawa Y., Funahashi Т., Kihara S., Shimomura I. Adiponectin and metabolic syndrome. Arterioscler. Thromb. Vase. Biol. Med. 2004;24:29-34.</mixed-citation></citation-alternatives></ref><ref id="cit36"><label>36</label><citation-alternatives><mixed-citation xml:lang="ru">Miyoshi Y., Funahashi Т., Kihara S. et al. Association of serum adiponectin levels with breast cancer risk. Clin. Cancer Res. 2003;9:5699-5704.</mixed-citation><mixed-citation xml:lang="en">Miyoshi Y., Funahashi Т., Kihara S. et al. Association of serum adiponectin levels with breast cancer risk. Clin. Cancer Res. 2003;9:5699-5704.</mixed-citation></citation-alternatives></ref><ref id="cit37"><label>37</label><citation-alternatives><mixed-citation xml:lang="ru">Moreland L.W. Drugs that block tumour necrosis factor: experience in patients with rheumatoid arthritis. Pharmacoeconomics. 2004;22(Suppl. 2):39-53.</mixed-citation><mixed-citation xml:lang="en">Moreland L.W. Drugs that block tumour necrosis factor: experience in patients with rheumatoid arthritis. Pharmacoeconomics. 2004;22(Suppl. 2):39-53.</mixed-citation></citation-alternatives></ref><ref id="cit38"><label>38</label><citation-alternatives><mixed-citation xml:lang="ru">Nilsson M., Johnsen R., Ye W. Obesity and estrogen as risk factors for gastroesophageal reflux symptoms: risk of esophageal adenocarcinoma. JAMA. 2003;290:66-72.</mixed-citation><mixed-citation xml:lang="en">Nilsson M., Johnsen R., Ye W. Obesity and estrogen as risk factors for gastroesophageal reflux symptoms: risk of esophageal adenocarcinoma. JAMA. 2003;290:66-72.</mixed-citation></citation-alternatives></ref><ref id="cit39"><label>39</label><citation-alternatives><mixed-citation xml:lang="ru">Paltoo D., Woodson K., Taylor P. et al. Pro 12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) gene and risk of prostate cancer in a large cancer prevention study. Cancer Lett. 2003;191:67-74.</mixed-citation><mixed-citation xml:lang="en">Paltoo D., Woodson K., Taylor P. et al. Pro 12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma (PPAR-gamma) gene and risk of prostate cancer in a large cancer prevention study. Cancer Lett. 2003;191:67-74.</mixed-citation></citation-alternatives></ref><ref id="cit40"><label>40</label><citation-alternatives><mixed-citation xml:lang="ru">Petridou E., Belechri M., Dessypris N. et al. Leptin and body mass index in relation to endometrial cancer risk. Ann. Nutr. Metab.2002;46:147-151.</mixed-citation><mixed-citation xml:lang="en">Petridou E., Belechri M., Dessypris N. et al. Leptin and body mass index in relation to endometrial cancer risk. Ann. Nutr. Metab.2002;46:147-151.</mixed-citation></citation-alternatives></ref><ref id="cit41"><label>41</label><citation-alternatives><mixed-citation xml:lang="ru">Phillips S.A., Ciaraldi T., Kong A. et al. Modulation of circulating and adipose tissue adiponectin levels by antidiabetic therapy. Diabetes. 2003;52:667-674.</mixed-citation><mixed-citation xml:lang="en">Phillips S.A., Ciaraldi T., Kong A. et al. Modulation of circulating and adipose tissue adiponectin levels by antidiabetic therapy. Diabetes. 2003;52:667-674.</mixed-citation></citation-alternatives></ref><ref id="cit42"><label>42</label><citation-alternatives><mixed-citation xml:lang="ru">Reaven G. Pathophysiology of insulin resistance in human disease. Physiol. Rev. 1995;75:473-486.</mixed-citation><mixed-citation xml:lang="en">Reaven G. Pathophysiology of insulin resistance in human disease. Physiol. Rev. 1995;75:473-486.</mixed-citation></citation-alternatives></ref><ref id="cit43"><label>43</label><citation-alternatives><mixed-citation xml:lang="ru">Rose D., Komninou D., Stephenson G.D. Obesity, adipocytokines, and insulin resistance in breast cancer. Obes. Rev. 2004;5:153-165.</mixed-citation><mixed-citation xml:lang="en">Rose D., Komninou D., Stephenson G.D. Obesity, adipocytokines, and insulin resistance in breast cancer. Obes. Rev. 2004;5:153-165.</mixed-citation></citation-alternatives></ref><ref id="cit44"><label>44</label><citation-alternatives><mixed-citation xml:lang="ru">Seckl J.R., Morton N.M., Chapman K.E., Walker B.R. Glucocorticoids and 11 beta-hydroxysteroid dehydrogenase in adipose tissue. Recent Progr. Horm. Res. 2004;59:359-393.</mixed-citation><mixed-citation xml:lang="en">Seckl J.R., Morton N.M., Chapman K.E., Walker B.R. Glucocorticoids and 11 beta-hydroxysteroid dehydrogenase in adipose tissue. Recent Progr. Horm. Res. 2004;59:359-393.</mixed-citation></citation-alternatives></ref><ref id="cit45"><label>45</label><citation-alternatives><mixed-citation xml:lang="ru">Sesti G., Perego L., Cardellini M. et al. Impact of Common Polymorphisms in Candidate Genes for Insulin Resistance and Obesity. J. Clin. Endocrinol. Metabol. 2005;90:5064-5069.</mixed-citation><mixed-citation xml:lang="en">Sesti G., Perego L., Cardellini M. et al. Impact of Common Polymorphisms in Candidate Genes for Insulin Resistance and Obesity. J. Clin. Endocrinol. Metabol. 2005;90:5064-5069.</mixed-citation></citation-alternatives></ref><ref id="cit46"><label>46</label><citation-alternatives><mixed-citation xml:lang="ru">Severson R.K., Grove J.S., Nomura A.M.Y., Stemmermann G.N. Body mass and prostatic cancer: a prospective study. Brit. Med. J. 1988;297:713-715.</mixed-citation><mixed-citation xml:lang="en">Severson R.K., Grove J.S., Nomura A.M.Y., Stemmermann G.N. Body mass and prostatic cancer: a prospective study. Brit. Med. J. 1988;297:713-715.</mixed-citation></citation-alternatives></ref><ref id="cit47"><label>47</label><citation-alternatives><mixed-citation xml:lang="ru">Tannenbaum A., Silverstone H. Nutrition in relation to cancer. Adv. Cancer Res. 1953;1:451-501.</mixed-citation><mixed-citation xml:lang="en">Tannenbaum A., Silverstone H. Nutrition in relation to cancer. Adv. Cancer Res. 1953;1:451-501.</mixed-citation></citation-alternatives></ref><ref id="cit48"><label>48</label><citation-alternatives><mixed-citation xml:lang="ru">Tessitore L., Vizio В., Pesola D. et al. Adipocyte expression and circulating levels of leptin increase in both gynaecological and breast cancer patients. Int. J. Oncol. 2004;24:1529-1535.</mixed-citation><mixed-citation xml:lang="en">Tessitore L., Vizio В., Pesola D. et al. Adipocyte expression and circulating levels of leptin increase in both gynaecological and breast cancer patients. Int. J. Oncol. 2004;24:1529-1535.</mixed-citation></citation-alternatives></ref><ref id="cit49"><label>49</label><citation-alternatives><mixed-citation xml:lang="ru">Tomlinson J.W., Stewart P.M. The functional consequences of 11 beta-hydroxysteroid dehydrogenase expression in adipose tissue. Horm. Metab. Res. 2002;34:746-751.</mixed-citation><mixed-citation xml:lang="en">Tomlinson J.W., Stewart P.M. The functional consequences of 11 beta-hydroxysteroid dehydrogenase expression in adipose tissue. Horm. Metab. Res. 2002;34:746-751.</mixed-citation></citation-alternatives></ref><ref id="cit50"><label>50</label><citation-alternatives><mixed-citation xml:lang="ru">Ursin G., Longnecker M:, Haile R.W., Greenland S. A meta-analysis of body mass index and risk of premenopausal breast cancer. Epidemiology. 1995;6:137-141.</mixed-citation><mixed-citation xml:lang="en">Ursin G., Longnecker M:, Haile R.W., Greenland S. A meta-analysis of body mass index and risk of premenopausal breast cancer. Epidemiology. 1995;6:137-141.</mixed-citation></citation-alternatives></ref><ref id="cit51"><label>51</label><citation-alternatives><mixed-citation xml:lang="ru">Weinberg R.A. How cancer arises. Sci. Amer. 1996;275:32-41.</mixed-citation><mixed-citation xml:lang="en">Weinberg R.A. How cancer arises. Sci. Amer. 1996;275:32-41.</mixed-citation></citation-alternatives></ref><ref id="cit52"><label>52</label><citation-alternatives><mixed-citation xml:lang="ru">Yazdani-Biuki В., Stelzl H., Brezinschek H. et al. Improvement of insulin sensitivity in insulin resistant subjects during prolonged treatment with the anti-TNF-alpha antibody infliximab. Eur. J. Clin. Invest. 2004;34:641-642.</mixed-citation><mixed-citation xml:lang="en">Yazdani-Biuki В., Stelzl H., Brezinschek H. et al. Improvement of insulin sensitivity in insulin resistant subjects during prolonged treatment with the anti-TNF-alpha antibody infliximab. Eur. J. Clin. Invest. 2004;34:641-642.</mixed-citation></citation-alternatives></ref><ref id="cit53"><label>53</label><citation-alternatives><mixed-citation xml:lang="ru">Zhu Z., Jiang W., McGinley J.N..Thompson H.J. 2-deoxyglucose as an energy restriction mimetic agent: effects on mammary carcinogenesis and on mammary tumor cell growth in vitro. Cancer Res. 2005;65:7023-7030.</mixed-citation><mixed-citation xml:lang="en">Zhu Z., Jiang W., McGinley J.N..Thompson H.J. 2-deoxyglucose as an energy restriction mimetic agent: effects on mammary carcinogenesis and on mammary tumor cell growth in vitro. Cancer Res. 2005;65:7023-7030.</mixed-citation></citation-alternatives></ref><ref id="cit54"><label>54</label><citation-alternatives><mixed-citation xml:lang="ru">Zimmet P. Globalization, coca-colonization and the chronic disease epidemic: can the Doomsday scenario be averted? J. Intern. Med. 2000;247:301-310.</mixed-citation><mixed-citation xml:lang="en">Zimmet P. Globalization, coca-colonization and the chronic disease epidemic: can the Doomsday scenario be averted? J. Intern. Med. 2000;247:301-310.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
