ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/2071-8713-4838ometendo-4838Research ArticleСтатьиArticlesУровни резистина, адипонектинаи инсулинорезистентности у пациентов с разнойстепенью нарушений углеводного обменаUrovni rezistina, adiponektinai insulinorezistentnosti u patsientov s raznoystepen'yu narusheniy uglevodnogo obmenaSkudaevaE Ssolomonova.el@yandex.ruPashentsevaA Va-pashentseva@yandex.ruVerbovoyA F-20111509201183№3 (2011)5760Copyright © Skudaeva E.S., Pashentseva A.V., Verbovoy A.F., 20112011Skudaeva E.S., Pashentseva A.V., Verbovoy A.F.Skudaeva E.S., Pashentseva A.V., Verbovoy A.F.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/4838

В основе патогенеза этого сахарного диабета 2 типа (СД2) лежат ожирение и инсулинорезистентность. Жировая ткань является гормонально активной системой, которая вырабатывает адипонектин, резистин и другие адипокины. В статье представлены результаты исследования, проведенного с целью изучения роли адипонектина, резистина в развитии инсулинорезистентности у лиц с нарушенной толерантностью к глюкозе (НТГ) и СД2. Выявлено снижение уровня адипонек- тина на фоне инсулинорезистентности у женщин и с НТГ, и с СД2, у мужчин только при СД2. Уровень резистина повышен у пациентов и с НТГ, и с СД2.

The basis of type 2 diabetes is obesity and insulin resistance. Fat tissue is hormonaly active system which produces adiponectin, resistin and other adipokines. These substances participate in development of insulin resistance. The article presents the results of a study conducted to examine the role of adiponectin, resistin in development of insulin resistance in patients with IGT and type 2 diabetes. The reduction of adiponectin level and insulin resistance was found in women suffering from IGF or type 2 diabetes and in men with only type 2 diabetes. Resistin levels were increased in the examined patients with IGT and with type 2 diabetes.

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The authors declare that there are no conflicts of interest present.