ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/2071-8713-4832ometendo-4832Research ArticleСтатьиArticlesАнтидиабетический бигуанид метформинкак геропротектор и антиканцерогенAntidiabeticheskiy biguanid metforminkak geroprotektor i antikantserogenAnisimovV Naging@mail.ru20111509201183№3 (2011)1824Copyright © Anisimov V.N., 20112011Anisimov V.N.Anisimov V.N.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/4832

В cтатье представлены данные, свидетельствующие о ключевой роли системы гормон роста/инсулиноподобный фактор роста-1 (IGF-1)/инсулин в механизмах старения у животных разных видов и человека. Обсуждаются перспективы генетических модификаций и применения антидиабетических бигуанидов для профилактики преждевременного старения и развития новообразований, механизмы их геропротекторного и антиканцерогенного эффектов.

Growth hormone (GH)/insulin-like growth factor 1 (IGF-1)/insulin, DAF-2 and insulin-receptor control life span in various species including human. It is possible that the life-prolonging effect of calorie restriction is due to a decrease in IGF-1 levels. A search for pharmacological modulators of life-span-extending mutations in the GH/IGF-1/insulin signaling pathway and mimetics of caloric restriction is a priority direction in the regulation of longevity. Some literature and our own observations suggest that antidiabetic drugs could be promising candidates for both life span extension and prevention of cancer

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The authors declare that there are no conflicts of interest present.