ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/2071-8713-4826ometendo-4826Research ArticleСтатьиArticlesОжирение и гипотиреозObesity and hypothyroidismZakharovaS M

к.м.н., с.н.с. отделения терапии эндокринопатий лечебно-диагностического отдела

smzakharova@mail.ruSavelievaL V

к.м.н., зав. отделением терапии эндокринопатий лечебно-диагностического отдела

larisa.savelieva@inbox.ruFadeevaM I

н.с. отделения терапии эндокринопатий лечебно-диагностического отдела

fm2004@bk.ru201315062013102№2 (2013)5458Copyright © Zakharova S.M., Savelieva L.V., Fadeeva M.I., 20132013Zakharova S.M., Savelieva L.V., Fadeeva M.I.Zakharova S.M., Savelieva L.V., Fadeeva M.I.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/4826

Связи с широким распространением как ожирения, так и гипотиреоза, врачам необходимо быть особенно внимательным к возможной дисфункции щитовидной железы у пациентов с ожирением. Существует двусторонняя связь между гормонами щитовидной железы и ожирением: как гипотиреоз может влиять на массу тела, так и жировая ткань может изменять уровень гормонов щитовидной железы. Уровень ТТГ и св.Т3 при ожирении часто оказывается повышенным, что опосредовано действием лептина. При лечении гипотиреоза препаратами Л-тироксина небольшое снижение массы тела обусловлено потерей воды, а не жира. Селективные аналоги тиреоидных гормонов, возможно, смогут стать средством для снижения массы тела путем увеличения расхода энергии у пациентов с ожирением при соблюдении гипокалорийной диеты.

Obesity and hypothyroidism are common diseases, and consequently clinicians should be particularly alert to the possibility of thyroid dysfunction in obese patients. The relationship between thyroid function and obesity is likely to be bidirectional, with hypothyroidism affecting weight, but obesity also influencing thyroid function. Both serum thyroid-stimulating hormone and fT3 are typically increased in obese individuals, an effect likely mediated by leptin. Following L-T4 treatment for overt hypothyroidism, weight loss appears to be modest and mediated primarily by loss of water weight rather than fat. Selected thyroid analogs might be a means by which to improve weight loss by increasing energy expenditure in obese patients during continued caloric deprivation

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The authors declare that there are no conflicts of interest present.