ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/2071-8713-3860ometendo-3860Research ArticleСтатьиArticlesОжирение и сонObesity and sleepStruevaN V

аспирант отделения терапии эндокринопатий ФГБУ Эндокринологический научный центр Минздрава РФ, Москва

nstr84@mail.ruPoluektovM G

к.м.н, доцент кафедры нервных болезней ФГБУ ВПО Первый московский государственный медицинский университет им. И.М. Сеченова, Москва

polouekt@mail.ruSavelevaL V

к.м.н., зав. отделением терапии эндокринопатий ФГБУ Эндокринологический научный центр Минздрава РФ, Москва

slv63@mail.ruMelnichenkoG A

акад., проф., д.м.н., директор Института клинической эндокринологии

melnich@endocrincentr.ru201330102013103№3 (2013)1118Copyright © Strueva N.V., Poluektov M.G., Saveleva L.V., Melnichenko G.A., 20132013Strueva N.V., Poluektov M.G., Saveleva L.V., Melnichenko G.A.Strueva N.V., Poluektov M.G., Saveleva L.V., Melnichenko G.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/3860

За последние десятилетия во многих странах мира все более острой становится проблема нарушений сна, причем это совпадает с ростом заболеваемости ожирением. Сложность изучения патогенетических связей между данными патологиями заключается в наличии множества факторов, влияющих как на развитие и прогрессирование ожирения, так и непосредственно на сон. Наиболее часто встречающиеся нарушения сна у пациентов с ожирением – синдром обструктивного апноэ сна и синдром инсомнии. В обзоре литературы представлены сведения о взаимосвязи нарушений сна с ожирением, где ключевая роль отводится изменению секреции гормонов, регулирующих аппетит и энергетический баланс.

Over the past decade in many countries of the world are an increasingly serious problem of sleep disorders and it coincides with the growing incidence of obesity. Complexity of pathogenesis links between the abnormalities consists of factors that influence the development and progression of obesity and directly to sleep. The most common sleep disorders in obese patients – obstructive sleep apnea and insomnia syndrome. This review provides information of correlation between obesity and sleep disorders, in which a key role is a hormones secretion changing which regulate appetite and energy balance

weightsleepobesitymetabolic syndromeobstructive sleep apnea syndromeinsomniaReferencesБузунов Р. В. Синдром обструктивного апноэ сна в сочетании с ожирением: особенности патогенеза, диагностики и лечения. Автореферат диссертации док. мед. наук, 2003.Бузунов Р. В. Синдром обструктивного апноэ сна в сочетании с ожирением: особенности патогенеза, диагностики и лечения. Автореферат диссертации док. мед. наук, 2003.Вейн А.М., Елигулашвили Т.С., Полуэктов М.Г. Синдром апноэ во сне. М.: Эйдос-Медиа, 2002.Вейн А.М., Елигулашвили Т.С., Полуэктов М.Г. Синдром апноэ во сне. М.: Эйдос-Медиа, 2002.Вознесенская Т.Г. Расстройства пищевого поведения при ожирении и их коррекция. Фарматека. 2009; 12: 91–94.Вознесенская Т.Г. Расстройства пищевого поведения при ожирении и их коррекция. Фарматека. 2009; 12: 91–94.Полуэктов М.Г., Левин Я.И. Инсомния и ее лечение снотворными препаратами. Лечащий врач. 2009; 5: 14–16.Полуэктов М.Г., Левин Я.И. Инсомния и ее лечение снотворными препаратами. Лечащий врач. 2009; 5: 14–16.Фадеева М.И., Савельева Л.В., Фадеев В.В. Синдром обструктивного апноэ сна в практике врача-эндокринолога. Метаболизм и ожирение. 2010; 1: 3–10.Фадеева М.И., Савельева Л.В., Фадеев В.В. Синдром обструктивного апноэ сна в практике врача-эндокринолога. Метаболизм и ожирение. 2010; 1: 3–10.Adam JA, Menheere PP, van Dielen FM, Soeters PB, Buurman WA, Greve JW. Decreased plasma orexin-A levels in obese individuals. Int J Obes Relat Metab Disord. 2002; 26(2): 274–6.Adam JA, Menheere PP, van Dielen FM, Soeters PB, Buurman WA, Greve JW. Decreased plasma orexin-A levels in obese individuals. Int J Obes Relat Metab Disord. 2002; 26(2): 274–6.American Academy of Sleep Medicine. International classification of sleep disorders, 2nd ed. Diagnostic and coding manual. Westchester, Ill: American Academy of Sleep Medicine, 2005.American Academy of Sleep Medicine. International classification of sleep disorders, 2nd ed. Diagnostic and coding manual. Westchester, Ill: American Academy of Sleep Medicine, 2005.Bass J, Takahashi JS. Circadian integration of metabolism and energetics. Science. 2010; 330 (6009): 1349–1354.Bass J, Takahashi JS. Circadian integration of metabolism and energetics. Science. 2010; 330 (6009): 1349–1354.Bass J, Turek FW. Sleepless in America: a pathway to obesity and the metabolic syndrome? Archives of Internal Medicine. 2005; 165: 15–16.Bass J, Turek FW. Sleepless in America: a pathway to obesity and the metabolic syndrome? Archives of Internal Medicine. 2005; 165: 15–16.Bratel T, Wennlund A, Carlstrom K. Pituitary reactivity, androgens and catecholamines in obstructive sleep apnoea. Effects of continuous positive airway pressure (CPAP). Respir Med. 1999; 93: 1–7.Bratel T, Wennlund A, Carlstrom K. Pituitary reactivity, androgens and catecholamines in obstructive sleep apnoea. Effects of continuous positive airway pressure (CPAP). Respir Med. 1999; 93: 1–7.Busquetsa X, Barbeb F, Barcelob A, de la Penab M, Sigritzb N et el. Decreased Plasma Levels of Orexin-A in Sleep Apnea. Respiration. 2004; 71: 575–579.Busquetsa X, Barbeb F, Barcelob A, de la Penab M, Sigritzb N et el. Decreased Plasma Levels of Orexin-A in Sleep Apnea. Respiration. 2004; 71: 575–579.Cappuccio FP, Taggart FM, Kandala NB et el. Meta-Analysis of Short Sleep Duration and Obesity in Children and Adults. Sleep. 2008; 31(5): 619–626.Cappuccio FP, Taggart FM, Kandala NB et el. Meta-Analysis of Short Sleep Duration and Obesity in Children and Adults. Sleep. 2008; 31(5): 619–626.Centers for Disease Control and Prevention (CDC). Effect of short sleep duration on daily activities United States, 2005–2008. 2011; 60: 2239–2422.Centers for Disease Control and Prevention (CDC). Effect of short sleep duration on daily activities United States, 2005–2008. 2011; 60: 2239–2422.Chin K, Shimizu K, Nakamura T, Narai N, Masuzaki H, Ogawa Y et al. Changes in intra-abdominal visceral fat and serum leptin levels in patients with obstructive sleep apnea syndrome following nasal continuous positive airway pressure therapy. Circulation. 1999; 100: 706–712.Chin K, Shimizu K, Nakamura T, Narai N, Masuzaki H, Ogawa Y et al. Changes in intra-abdominal visceral fat and serum leptin levels in patients with obstructive sleep apnea syndrome following nasal continuous positive airway pressure therapy. Circulation. 1999; 100: 706–712.Jonge L, Zhao X, Mattingly MS, Zuber SM, Piaggi P et el. Poor Sleep Quality and Sleep Apnea Are Associated with Higher Resting Energy Expenditure in Obese Individuals with Short Sleep Duration. J Clin Endocrinol Metab. 2012; 97(8): 2881–2889.Jonge L, Zhao X, Mattingly MS, Zuber SM, Piaggi P et el. Poor Sleep Quality and Sleep Apnea Are Associated with Higher Resting Energy Expenditure in Obese Individuals with Short Sleep Duration. J Clin Endocrinol Metab. 2012; 97(8): 2881–2889.Elias CF, Aschkenasi C, Lee C, Kelly J, Ahima RS, Bjorbaek C, Flier JS, Saper CB, Elmquist JK. Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron 1999; 23: 775–786.Elias CF, Aschkenasi C, Lee C, Kelly J, Ahima RS, Bjorbaek C, Flier JS, Saper CB, Elmquist JK. Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area. Neuron 1999; 23: 775–786.Gary KA, Winokur A, Douglas SD, Kapoor S, Zaugg L, Dinges DF. Total sleep deprivation and the thyroid axis: effects of sleep and waking activity. Aviat Space Environ Med. 1996; 67(6): 513–9.Gary KA, Winokur A, Douglas SD, Kapoor S, Zaugg L, Dinges DF. Total sleep deprivation and the thyroid axis: effects of sleep and waking activity. Aviat Space Environ Med. 1996; 67(6): 513–9.Grandner MA, Hale L, Moore M, Patel NP. Mortality associated with short sleep duration: the evidence, the possible mechanisms, and the future. Sleep Med Rev. 2010; 14: 191–203.Grandner MA, Hale L, Moore M, Patel NP. Mortality associated with short sleep duration: the evidence, the possible mechanisms, and the future. Sleep Med Rev. 2010; 14: 191–203.Gunderson EP, Rifas-Shiman SL, Oken E, et al. Association of fewer hours of sleep at 6 months postpartum with substantial weight retention at 1 year postpartum. Am. J. Epidemiol. 2008; 167: 178–187.Gunderson EP, Rifas-Shiman SL, Oken E, et al. Association of fewer hours of sleep at 6 months postpartum with substantial weight retention at 1 year postpartum. Am. J. Epidemiol. 2008; 167: 178–187.Hall MH, Muldoon MF, Jennings JR et al. Self-Reported Sleep Duration is Associated with the Metabolic Syndrome in Midlife Adults. Sleep 2008; 31(5): 635–643.Hall MH, Muldoon MF, Jennings JR et al. Self-Reported Sleep Duration is Associated with the Metabolic Syndrome in Midlife Adults. Sleep 2008; 31(5): 635–643.Hasler G, Buysse DJ, Klaghofer R, et al. The association between short sleep duration and obesity in young adults: a 13-Year prospective study. Sleep. 2004; 27: 661–666.Hasler G, Buysse DJ, Klaghofer R, et al. The association between short sleep duration and obesity in young adults: a 13-Year prospective study. Sleep. 2004; 27: 661–666.Hastings M, O’Neill JS, Maywood ES. Circadian clocks: regulators of endocrine and metabolic rhythms. J Endocrinol. 2007; 195: 187–198.Hastings M, O’Neill JS, Maywood ES. Circadian clocks: regulators of endocrine and metabolic rhythms. J Endocrinol. 2007; 195: 187–198.Haynes AC, Chapman H, Taylor C, Moore GB et el. Anorectic, thermogenic and anti-obesity activity of a selective orexin-1 receptor antagonist in ob/ob mice. Regul. Pept. 2002; 104: 153–159.Haynes AC, Chapman H, Taylor C, Moore GB et el. Anorectic, thermogenic and anti-obesity activity of a selective orexin-1 receptor antagonist in ob/ob mice. Regul. Pept. 2002; 104: 153–159.Henley DE, Russell GM, Douthwaite JA et al. Hypothalamic-pituitary-adrenal axis activation in obstructive sleep apnea: the effect of continuous positive airway pressure therapy. J Clin Endocrinol Metab. 2009; 94: 4234–4242.Henley DE, Russell GM, Douthwaite JA et al. Hypothalamic-pituitary-adrenal axis activation in obstructive sleep apnea: the effect of continuous positive airway pressure therapy. J Clin Endocrinol Metab. 2009; 94: 4234–4242.Hins J, Sériès F, Alméras N, Tremblay A Relationship between severity of nocturnal desaturation and adaptive thermogenesis: preliminary data of apneic patients tested in a whole-body indirect calorimetry chamber. Int J Obes (Lond). 2006; 30: 574–577.Hins J, Sériès F, Alméras N, Tremblay A Relationship between severity of nocturnal desaturation and adaptive thermogenesis: preliminary data of apneic patients tested in a whole-body indirect calorimetry chamber. Int J Obes (Lond). 2006; 30: 574–577.Wenyu H, Ramsey KM, Marcheva B, Bass J. Circadian rhythms, sleep, and metabolism. Clin Invest. 2011; 121(6): 2133–2141.Wenyu H, Ramsey KM, Marcheva B, Bass J. Circadian rhythms, sleep, and metabolism. Clin Invest. 2011; 121(6): 2133–2141.Ibrahim HS, Ghotny SS El, Morsy EY.et.el Role of orexine-A in obesity and type 2 diabetes in male patients and its correlation with leptin hormone. Alexandria Bulletin. 2006; 42(3): 825–826.Ibrahim HS, Ghotny SS El, Morsy EY.et.el Role of orexine-A in obesity and type 2 diabetes in male patients and its correlation with leptin hormone. Alexandria Bulletin. 2006; 42(3): 825–826.Ip MS, Lam B, Ng MM, Lam WK, Tsang KW, Lam KS. Obstructive sleep apnea is independently associated with insulin resistance. American Journal of Respiratory and Critical Care Medicine. 2002; 165 (5): 670–676.Ip MS, Lam B, Ng MM, Lam WK, Tsang KW, Lam KS. Obstructive sleep apnea is independently associated with insulin resistance. American Journal of Respiratory and Critical Care Medicine. 2002; 165 (5): 670–676.Iyer SR, Iyer RR. Sleep and obesity in the causation of metabolic syndrome. Int J Diab Dev Ctries. 2006; 26(2): 63–69.Iyer SR, Iyer RR. Sleep and obesity in the causation of metabolic syndrome. Int J Diab Dev Ctries. 2006; 26(2): 63–69.Jung CM, Melanson EL, Frydendall EJ, Perreault L, Eckel RH, Wright KP Energy expenditure during sleep, sleep deprivation and sleep following sleep deprivation in adult humans. J Physiol. 2011; 589: 235–244.Jung CM, Melanson EL, Frydendall EJ, Perreault L, Eckel RH, Wright KP Energy expenditure during sleep, sleep deprivation and sleep following sleep deprivation in adult humans. J Physiol. 2011; 589: 235–244.Kajaste S, Brander PE, Telakivi T, Partinen M, Mustajoki P. A cognitive-behavioral weight reduction program in the treatment of obstructive sleep apnea syndrome with or without initial nasal CPAP: a randomized study. Sleep Med. 2004; 5(2): 125–31.Kajaste S, Brander PE, Telakivi T, Partinen M, Mustajoki P. A cognitive-behavioral weight reduction program in the treatment of obstructive sleep apnea syndrome with or without initial nasal CPAP: a randomized study. Sleep Med. 2004; 5(2): 125–31.Kessler L, Nedeltcheva A, Imperial J, Penev PD. Changes in Serum TSH and Free T4 during Human Sleep Restriction. Sleep. 2010; 33(8): 1115–1118.Kessler L, Nedeltcheva A, Imperial J, Penev PD. Changes in Serum TSH and Free T4 during Human Sleep Restriction. Sleep. 2010; 33(8): 1115–1118.Killick R, Banks S, Liu PY. Implications of sleep restriction and recovery on metabolic outcomes. J Clin Endocrinol Metab. 2012; 97(11): 3876–90.Killick R, Banks S, Liu PY. Implications of sleep restriction and recovery on metabolic outcomes. J Clin Endocrinol Metab. 2012; 97(11): 3876–90.Kim NH. Obstructive sleep apnea and abnormal glucose metabolism. Diabetes Metab J. 2012; 36(4): 268–72.Kim NH. Obstructive sleep apnea and abnormal glucose metabolism. Diabetes Metab J. 2012; 36(4): 268–72.Kohler M, Stoewhas AC, Ayers L, Senn O, Bloch KE, Russi EW, Stradling JR. Effects of continuous positive airway pressure therapy withdrawal in patients with obstructive sleep apnea: a randomized controlled trial. Am J Respir Crit Care Med. 2011; 184: 1192–1129.Kohler M, Stoewhas AC, Ayers L, Senn O, Bloch KE, Russi EW, Stradling JR. Effects of continuous positive airway pressure therapy withdrawal in patients with obstructive sleep apnea: a randomized controlled trial. Am J Respir Crit Care Med. 2011; 184: 1192–1129.Kuru M, Ueta Y, Serino R, Nakazato M, Yamamoto Y, Shibuya I, Yamashita H.: Centrally administered orexin/hypocretin activates HPA axis in rats. Neuroreport. 2000; 11: 1977–1980.Kuru M, Ueta Y, Serino R, Nakazato M, Yamamoto Y, Shibuya I, Yamashita H.: Centrally administered orexin/hypocretin activates HPA axis in rats. Neuroreport. 2000; 11: 1977–1980.Myhill PC, Davis WA, Peters KE, Chubb SA, Hillman D, Davis TM Effect of continuous positive airway pressure therapy on cardiovascular risk factors in patients with type 2 diabetes and obstructive sleep apnea. J Clin Endocrinol Metab. 2012; 97(11): 4212–8.Myhill PC, Davis WA, Peters KE, Chubb SA, Hillman D, Davis TM Effect of continuous positive airway pressure therapy on cardiovascular risk factors in patients with type 2 diabetes and obstructive sleep apnea. J Clin Endocrinol Metab. 2012; 97(11): 4212–8.Lallukka T, Haario P, Lahelma E, Rahkonen O. Associations of relative weight with subsequent changes over time in insomnia symptoms: a follow-up study among middle-aged women and men. Sleep Med. 2012; 13(10): 1271–9.Lallukka T, Haario P, Lahelma E, Rahkonen O. Associations of relative weight with subsequent changes over time in insomnia symptoms: a follow-up study among middle-aged women and men. Sleep Med. 2012; 13(10): 1271–9.Lanfranco F, Motta G, Minetto MA, Baldi M, Balbo M, Ghigo E, Arvat E, Maccario M. Neuroendocrine Alterations in Obese Patients with Sleep Apnea Syndrome. Int J Endocrinol. 2010; 2010: 474–518.Lanfranco F, Motta G, Minetto MA, Baldi M, Balbo M, Ghigo E, Arvat E, Maccario M. Neuroendocrine Alterations in Obese Patients with Sleep Apnea Syndrome. Int J Endocrinol. 2010; 2010: 474–518.Luboshitzky R, Lavie L, Shen-Orr Z, Herer P. Luteinizing Altered Hormone and Testosterone Secretion in Middle-Aged Obese Men with Obstructive Sleep Apnea. Obesity Research. 2005; 13 (4): 780–786.Luboshitzky R, Lavie L, Shen-Orr Z, Herer P. Luteinizing Altered Hormone and Testosterone Secretion in Middle-Aged Obese Men with Obstructive Sleep Apnea. Obesity Research. 2005; 13 (4): 780–786.Luboshitzky R, Aviv A, Hefetz A, Herer P, Shen-Orr Z, Lavie L, Lavie P. Decreased Pituitary-Gonadal Secretion in Men with Obstructive Sleep Apnea The Journal of Clinical Endocrinology & Metabolis. 2002; 87 (7): 3394–3398.Luboshitzky R, Aviv A, Hefetz A, Herer P, Shen-Orr Z, Lavie L, Lavie P. Decreased Pituitary-Gonadal Secretion in Men with Obstructive Sleep Apnea The Journal of Clinical Endocrinology & Metabolis. 2002; 87 (7): 3394–3398.Lucassen EA, Rother KI, Cizza G: Interacting epidemics? Sleep curtailment, insulin resistance and obesity. Ann N Y Acad Sci. 2012; 1264: 110–34.Lucassen EA, Rother KI, Cizza G: Interacting epidemics? Sleep curtailment, insulin resistance and obesity. Ann N Y Acad Sci. 2012; 1264: 110–34.Nakamura M, Kanbayashi T, Sugiura T, Inoue Y. Relationship between clinical characteristics of narcolepsy and CSF orexin-A levels. J. Sleep Res. 2011; 20: 45–49.Nakamura M, Kanbayashi T, Sugiura T, Inoue Y. Relationship between clinical characteristics of narcolepsy and CSF orexin-A levels. J. Sleep Res. 2011; 20: 45–49.National Sleep Foundation. Sleep in America Poll. Washington DC; 2005.National Sleep Foundation. Sleep in America Poll. Washington DC; 2005.Nedeltcheva AV, Kilkus JM, Imperial J, Kasza K, Schoeller DA, Penev PD. Sleep curtailment is accompanied by increased intake of calories from snacks. Am J Clin Nutr. 2009; 89: 126–133.Nedeltcheva AV, Kilkus JM, Imperial J, Kasza K, Schoeller DA, Penev PD. Sleep curtailment is accompanied by increased intake of calories from snacks. Am J Clin Nutr. 2009; 89: 126–133.Penev PD. Sleep deprivation and energy metabolism: to sleep, perchance to eat? Curr Opin Endocrinol Diabetes Obes. 2007; 14: 374–381.Penev PD. Sleep deprivation and energy metabolism: to sleep, perchance to eat? Curr Opin Endocrinol Diabetes Obes. 2007; 14: 374–381.Peppard PE, Young T, Palta M et al. Longitudinal study of moderate weight change and sleep-disordered breathing. JAMA. 2000; 284: 3015–3021.Peppard PE, Young T, Palta M et al. Longitudinal study of moderate weight change and sleep-disordered breathing. JAMA. 2000; 284: 3015–3021.Rodenbeck A, Huether G, Ruther E, Hajak G. Interactions between evening and nocturnal cortisol secretion and sleep parameters in patients with severe chronic primary insomnia. Neurosci Lett. 2002; 324: 159–163.Rodenbeck A, Huether G, Ruther E, Hajak G. Interactions between evening and nocturnal cortisol secretion and sleep parameters in patients with severe chronic primary insomnia. Neurosci Lett. 2002; 324: 159–163.Sakurai T, Amemiya A, Ishil M, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998; 92: 573–585.Sakurai T, Amemiya A, Ishil M, et al. Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell. 1998; 92: 573–585.Salvador J, Iriarte J, Silva C, Gomez AJ, Diez CA, Fruhbeck G. The obstructive sleep apnea syndrome in obesity: A conspirator in the shadow. Rev Med Univ Navarra. 2004; 48: 55–62.Salvador J, Iriarte J, Silva C, Gomez AJ, Diez CA, Fruhbeck G. The obstructive sleep apnea syndrome in obesity: A conspirator in the shadow. Rev Med Univ Navarra. 2004; 48: 55–62.Sassin JF, Parker DC, Mace JW, Gotlin RW, Johnson LC, Rossman LG. Human growth hormone release: relation to slow-wave sleep and sleep-waking cycles. Science. 1969; 165: 513–515.Sassin JF, Parker DC, Mace JW, Gotlin RW, Johnson LC, Rossman LG. Human growth hormone release: relation to slow-wave sleep and sleep-waking cycles. Science. 1969; 165: 513–515.Scheer FA, Hilton MF, Mantzoros CS, Shea SA. Adverse metabolic and cardiovascular consequences of circadian misalignment. Proc Natl Acad Sci U S A. 2009; 106(11): 4453–4458.Scheer FA, Hilton MF, Mantzoros CS, Shea SA. Adverse metabolic and cardiovascular consequences of circadian misalignment. Proc Natl Acad Sci U S A. 2009; 106(11): 4453–4458.Schmoller A, Eberhardt F, Jauch-Chara K, Schweiger U, Zabel P, Peters A et al. Continuous positive airway pressure therapy decreases evening cortisol concentrations in patients with severe obstructive sleep apnea. Metab. 2009; 58: 848–853.Schmoller A, Eberhardt F, Jauch-Chara K, Schweiger U, Zabel P, Peters A et al. Continuous positive airway pressure therapy decreases evening cortisol concentrations in patients with severe obstructive sleep apnea. Metab. 2009; 58: 848–853.Scott EM, Carter AM, Grant PJ. Association between polymorphisms in the Clock gene, obesity and the metabolic syndrome in man. Int J Obes (Lond). 2008; 32(4): 658–662.Scott EM, Carter AM, Grant PJ. Association between polymorphisms in the Clock gene, obesity and the metabolic syndrome in man. Int J Obes (Lond). 2008; 32(4): 658–662.Shamsuzzaman AS, Gersh BJ, Somers VK. Obstructive sleep apnea: implications for cardiac and vascular disease. JAMA. 2003; 290: 1906–1914.Shamsuzzaman AS, Gersh BJ, Somers VK. Obstructive sleep apnea: implications for cardiac and vascular disease. JAMA. 2003; 290: 1906–1914.Sharma SK, Agrawal S, Damodaran D, Sreenivas V, Kadhiravan T, Lakshmy R, Jagia P, Kumar A. CPAP for the metabolic syndrome in patients with obstructive sleep apnea. N Engl J Med. 2011; 365(24): 2277–86.Sharma SK, Agrawal S, Damodaran D, Sreenivas V, Kadhiravan T, Lakshmy R, Jagia P, Kumar A. CPAP for the metabolic syndrome in patients with obstructive sleep apnea. N Engl J Med. 2011; 365(24): 2277–86.Spiegel K, Tasali E, Leproult R, Scherberg N, Van Cauter E. Twenty-four-hour profiles of acylated and total ghrelin: relationship with glucose levels and impact of time of day and sleep. J. Clin. Endocrinol. Metab. 2011; 96: 486–493.Spiegel K, Tasali E, Leproult R, Scherberg N, Van Cauter E. Twenty-four-hour profiles of acylated and total ghrelin: relationship with glucose levels and impact of time of day and sleep. J. Clin. Endocrinol. Metab. 2011; 96: 486–493.Spiegel K, Tasali E, Penev P, Van Cauter E. Brief communication: sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite. Ann Intern Med. 2004; 141: 846–850.Spiegel K, Tasali E, Penev P, Van Cauter E. Brief communication: sleep curtailment in healthy young men is associated with decreased leptin levels, elevated ghrelin levels, and increased hunger and appetite. Ann Intern Med. 2004; 141: 846–850.St-Onge MP, Roberts AL, Chen J, Kelleman M, O'Keeffe M, RoyChoudhury A, Jones PJ. Short sleep duration increases energy intakes but does not change energy expenditure in normal-weight individuals. Am J Clin Nutr. 2011 Aug; 94(2): 410–6.St-Onge MP, Roberts AL, Chen J, Kelleman M, O'Keeffe M, RoyChoudhury A, Jones PJ. Short sleep duration increases energy intakes but does not change energy expenditure in normal-weight individuals. Am J Clin Nutr. 2011 Aug; 94(2): 410–6.Stranges S, Cappucchio FP, Kandala NB, et al. Cross-sectional versus prospective associations of sleep duration with changes in relative weight and body fat distribution: the Whitehall II Study. Am. J. Epidemiol. 2008; 167: 321–329.Stranges S, Cappucchio FP, Kandala NB, et al. Cross-sectional versus prospective associations of sleep duration with changes in relative weight and body fat distribution: the Whitehall II Study. Am. J. Epidemiol. 2008; 167: 321–329.Taheri S, Lin L, Austin D, Young T, Mignot E. Short Sleep Duration Is Associated with Reduced Leptin, Elevated Ghrelin, and Increased Body Mass Index. PLoS Med. 2004; 1(3): 62.Taheri S, Lin L, Austin D, Young T, Mignot E. Short Sleep Duration Is Associated with Reduced Leptin, Elevated Ghrelin, and Increased Body Mass Index. PLoS Med. 2004; 1(3): 62.Tasali, Leproult R, Ehrmann DA, Van Cauter E. Slow-wave sleep and the risk of type 2 diabetes in humans. Proceedings of the National Academy of Sciences of the United States of America. 2008; 105 (3): 1044–1049.Tasali, Leproult R, Ehrmann DA, Van Cauter E. Slow-wave sleep and the risk of type 2 diabetes in humans. Proceedings of the National Academy of Sciences of the United States of America. 2008; 105 (3): 1044–1049.Teske JA, Billington CJ, Kotz CM. Hypocretin/orexin and energy expenditure. Acta Physiol (Oxf). 2010; 198(3): 303–12.Teske JA, Billington CJ, Kotz CM. Hypocretin/orexin and energy expenditure. Acta Physiol (Oxf). 2010; 198(3): 303–12.Thomasouli MA, Brady EM, Davies MJ, Hall AP, Khunti K, Morris DH, Gray LJ. The impact of diet and lifestyle management strategies for obstructive sleep apnoea in adults: a systematic review and meta-analysis of randomised controlled trials. Sleep Breath. 2013 Jan 30.Thomasouli MA, Brady EM, Davies MJ, Hall AP, Khunti K, Morris DH, Gray LJ. The impact of diet and lifestyle management strategies for obstructive sleep apnoea in adults: a systematic review and meta-analysis of randomised controlled trials. Sleep Breath. 2013 Jan 30.Tomfohr LM, Edwards KM, Dimsdale JE. Is obstructive sleep apnea associated with cortisol levels? A systematic review of the research evidence. Sleep Med Rev. 2012; 16: 243–249.Tomfohr LM, Edwards KM, Dimsdale JE. Is obstructive sleep apnea associated with cortisol levels? A systematic review of the research evidence. Sleep Med Rev. 2012; 16: 243–249.Ursavas A, Karadag M, Ilcol YO, Ercan I, Burgazlioglu B, Coskun F, Gozu RO. Low level of IGF-1 in obesity may be related to obstructive sleep apnea syndrome. Lung. 2007 Sep-Oct; 185(5): 309–14.Ursavas A, Karadag M, Ilcol YO, Ercan I, Burgazlioglu B, Coskun F, Gozu RO. Low level of IGF-1 in obesity may be related to obstructive sleep apnea syndrome. Lung. 2007 Sep-Oct; 185(5): 309–14.Ursavas A, Ozarda Y, Nalci N, Karadag M, Ercument E. Ghrelin, leptin, adiponectin, and resistin levels in sleep apnea syndrome: Role of obesity. Thorax. 2010; 5(3): 161–165.Ursavas A, Ozarda Y, Nalci N, Karadag M, Ercument E. Ghrelin, leptin, adiponectin, and resistin levels in sleep apnea syndrome: Role of obesity. Thorax. 2010; 5(3): 161–165.Vgontzas AN, Bixler EO, Lin HM, Prolo P, Mastorakos G, Vela-Bueno A, Kales A, Chrousos GP. Chronic insomnia is associated with nyctohemeral activation of the hypothalamic-pituitary-adrenal axis: clinical implications. J Clin Endocrinol Metab. 2001; 86: 3787–3794.Vgontzas AN, Bixler EO, Lin HM, Prolo P, Mastorakos G, Vela-Bueno A, Kales A, Chrousos GP. Chronic insomnia is associated with nyctohemeral activation of the hypothalamic-pituitary-adrenal axis: clinical implications. J Clin Endocrinol Metab. 2001; 86: 3787–3794.Vgontzas AN, Tsigos C, Bixler EO et al. Chronic insomnia and activity of the stress system: a preliminary study. J Psychosom Res. 1998; 45: 21–31.Vgontzas AN, Tsigos C, Bixler EO et al. Chronic insomnia and activity of the stress system: a preliminary study. J Psychosom Res. 1998; 45: 21–31.Watanabe M, Kikuchi H, Tanaka K, Takahashi M. Association of short sleep duration with weight gain and obesity at 1-year follow-up: a large-scale prospective study. Sleep. 2010; 33: 161–167.Watanabe M, Kikuchi H, Tanaka K, Takahashi M. Association of short sleep duration with weight gain and obesity at 1-year follow-up: a large-scale prospective study. Sleep. 2010; 33: 161–167.Weibel L, Follenius M, Spiegel K, Gronfier C, Brandenberger G. Growth hormone secretion in night workers. Chronobiol Int. 1997; 14: 49–60.Weibel L, Follenius M, Spiegel K, Gronfier C, Brandenberger G. Growth hormone secretion in night workers. Chronobiol Int. 1997; 14: 49–60.Woon PY et al. Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetes. Proc Natl Acad Sci U S A. 2007; 104(36): 14412–14417.Woon PY et al. Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetes. Proc Natl Acad Sci U S A. 2007; 104(36): 14412–14417.Yamanaka A. Hypothalamic Orexin Neurons Regulate Arousal According to Energy Balance in Mice. Neuron. 2003; 38 (5): 701–713.Yamanaka A. Hypothalamic Orexin Neurons Regulate Arousal According to Energy Balance in Mice. Neuron. 2003; 38 (5): 701–713.Zeitzer JM, Buckmaster CL et al. Increasing length of wakefulness and modulation of hypocretin-1 in the wake-consolidated squirrel monkey. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2007; 293: 1736–1742.Zeitzer JM, Buckmaster CL et al. Increasing length of wakefulness and modulation of hypocretin-1 in the wake-consolidated squirrel monkey. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2007; 293: 1736–1742.

The authors declare that there are no conflicts of interest present.