ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/omet13304ometendo-13304Research ArticleОБЗОРЫREVIEWSВитамин D – недостающий элемент в терапии ожирения и сахарного диабета?Vitamin D the missing element in the treatment of obesity and diabetes?https://orcid.org/0000-0001-6539-466XПигароваЕ. А.PigarovaE. A.

Пигарова Екатерина Александровна, д.м.н. 

Scopus Author ID: 55655098500; Researcher ID: T-9424-2018

Москва

Ekaterina A. Pigarova, MD, PhD

Scopus Author ID: 55655098500; Researcher ID: T-9424-2018

Moscow

kpigarova@gmail.comhttps://orcid.org/0000-0002-4388-6097КацобашвилиИ. А.KatsobashviliI. A.

Кацобашвили Илана Александровна 

117292, Москва, ул. Дм. Ульянова, д. 11

Ilana A. Katsobashvili, MD

11 Dm. Ulyanova street, 117292 Moscow

kacobashvili.ilana@mail.ruhttps://orcid.org/0000-0002-0327-4619ДзерановаЛ. К.DzeranovaL. K.

Дзеранова Лариса Константиновна , д.м.н.

Москва

Larisa K. Dzeranova, MD, PhD

Moscow

dzeranovalk@yandex.ruГНЦ РФ ФГБУ «НМИЦ эндокринологии им. академика И.И. Дедова» Минздрава РоссииРоссияEndocrinology Research CentreRussian Federation2026180720262328595Copyright © Пигарова Е.А., Кацобашвили И.А., Дзеранова Л.К., 20262026Пигарова Е.А., Кацобашвили И.А., Дзеранова Л.К.Pigarova E.A., Katsobashvili I.A., Dzeranova L.K.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/13304

Восполнение дефицита витамина D оказывает убедительный положительный эффект на скелетную систему (профилактика рахита/остеомаляции; при выраженном дефиците — снижение риска некоторых переломов и падений). При этом для внекостных эффектов, к которым относят острые респираторные, сердечно-сосудистые и онкологические заболевания, сахарный диабет 2 типа (СД2) и ожирение, данные смешанные, поскольку крупные рандомизированные клинические исследования у неселективных популяций в целом не подтвердили значимого клинического преимущества назначения витамина D, тогда как метааналитические и подгрупповые данные указывают на значимую пользу у лиц с восполнением исходного дефицита. Режим дозирования и исходный статус 25(ОН)D являются ключевыми модификаторами эффекта. Поэтому в настоящее время эксперты рекомендуют целенаправленный подход — скрининг и коррекцию дефицита и недостаточности в группах риска с достижением и поддержанием целевого уровня витамина D. В данном обзоре литературы делается акцент на эффектах восполнения дефицита витамина D у пациентов с ожирением и нарушением углеводного обмена.

Vitamin D supplementation has a significant positive effect on the skeletal system (prevention of rickets/osteomalacia; in severe deficiency, reduction in the risk of certain fractures and falls). However, for extraskeletal effects, which include acute respiratory infections, cardiovascular diseases, cancer, type 2 diabetes, and obesity, the data are mixed. Large randomized clinical trials in non-selected populations have generally failed to confirm a significant clinical benefit from vitamin D supplementation, while meta-analytic and subgroup data indicate a significant benefit in individuals with corrected baseline deficiency. Dosage regimen and baseline 25(OH)D status are key effect modifiers. Therefore, experts currently recommend a targeted approach screening and correcting deficiency and insufficiency in at-risk groups, achieving and maintaining target vitamin D levels. This literature review focuses on the effects of vitamin D supplementation in patients with obesity and carbohydrate metabolism disorders.

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The authors declare that there are no conflicts of interest present.