ometendoОжирение и метаболизмObesity and metabolism2071-87132306-5524Endocrinology Research Centre10.14341/omet13257ometendo-13257Research ArticleОБЗОРЫREVIEWSРоль микробиоты кишечника и эндотоксемии в патогенезе артериальной гипертензии и метаболических нарушений (обзор)The role of intestinal microbiota and endotoxemia in the pathogenesis of arterial hypertension and metabolic disorders (REVIEW)https://orcid.org/0000-0001-6251-4179ПетелинаТ. И.PetelinaT. I.

Петелина Татьяна Ивановна, д.м.н. 

Researcher ID: I-8913-2017; Scopus Author ID: 6507194861

625026, ул. Мельникайте, д. 111,Томск

Tatiana I. Petelina, MD PhD 

Researcher ID: I-8913-2017; Scopus Author ID: 6507194861 

111 Melnikaite street, 625026 Tyumen 

petelina@infarkta.nethttps://orcid.org/0009-0001-4898-6089ГорбачевскийА. В.GorbachevskiiA. V.

Горбачевский Александр Владимирович , м.н.с.

Томск

Alexander V. Gorbachevskii 

Tomsk

GorbachevskijAV@infarkta.nethttps://orcid.org/0000-0002-2134-4107АвдееваК. С.AvdeevaK. S.

Авдеева Ксения Сергеевна , к.м.н. 

Researcher ID: J-1751-2017; Scopus Author ID: 57210713674

Томск

Ksenia S. Avdeeva 

Researcher ID: J-1751-2017; Scopus Author ID: 57210713674 

Tomsk

avdeeva_03@mail.ruhttps://orcid.org/0000-0002-0627-1907ВалееваЛ. Л.ValeevaL. L.

Валеева Лиана Леонидовна , м.н.с.

Researcher ID: NBX-2398-2025; ScopusAuthorID: 57304131200

Томск

Liana L. Valeeva 

Researcher ID: NBX-2398-2025; ScopusAuthorID: 57304131200 

Tomsk

valeeva@infarkta.nethttps://orcid.org/0000-0002-0587-0991КапустинаА. А.KapustinaA. A.

Капустина Анастасия Андреевна , м.н.с.

Томск

Anastasia A. Kapustina 

Tomsk

anastasiakap@yandex.ruТюменский кардиологический научный центр, Томский национальный исследовательский медицинский центр РАНРоссияTyumen Cardiology Research Center, Tomsk National Research Medical Center of the Russian Academy of SciencesRussian Federation2026180720262327784Copyright © Петелина Т.И., Горбачевский А.В., Авдеева К.С., Валеева Л.Л., Капустина А.А., 20262026Петелина Т.И., Горбачевский А.В., Авдеева К.С., Валеева Л.Л., Капустина А.А.Petelina T.I., Gorbachevskii A.V., Avdeeva K.S., Valeeva L.L., Kapustina A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://www.omet-endojournals.ru/jour/article/view/13257

Артериальная гипертензия является ведущим модифицируемым фактором риска сердечно-сосудистой заболеваемости. Образ жизни и характер питания играют важную роль как в патогенезе гипертензии, так и в развитии сопутствующих метаболических нарушений, включающих атеросклероз, ожирение и сахарный диабет 2 типа. Характер питания и развитие артериальной гипертензии с метаболическими нарушениями связаны с микробиотой кишечника, продуктами ее метаболизма и низкоинтенсивной несептической эндотоксемией, которая может развиваться как фоновое состояние. Осознанное управление составом микробиоты кишечника, ее метаболитами и проницаемостью стенки кишечника с помощью диетических стратегий может рассматриваться как один из подходов к профилактике и лечению артериальной гипертензии и метаболических нарушений.

Целью данного обзора является поиск, обобщение и обсуждение существующих литературных данных о роли метаболитов микробиоты кишечника в патогенезе развития артериальной гипертензии с метаболическими нарушениями, а также систематизация имеющихся данных о влиянии диеты на микробиоту кишечника у данной категории лиц. Материалы и методы: поиск и отбор литературных источников осуществлялся в системе опубликованных исследований в научных базах cyberleninka.ru, elibrary.ru, link.springer.com, frontiersin.org, pubmed.ncbi.nlm.nih.gov, Web of Science, Google Scholar и других.

Arterial hypertension is the leading modifiable risk factor for cardiovascular morbidity, and lifestyle and diet play an important role both in the pathogenesis of hypertension and in the development of concomitant metabolic disorders, including atherosclerosis, obesity, and type 2 diabetes mellitus. The nature of nutrition and the development of hypertension with metabolic disorders are largely related to the intestinal microbiota, the products of its metabolism and low-intensity non-septic endotoxemia, which can develop as a background condition. Conscious manipulation of the composition and metabolites of the intestinal microbiota and intestinal wall permeability through dietary strategies can be considered as one of the approaches in the prevention and treatment of hypertension and metabolic disorders. The aim of the review was to search, summarize and discuss real literature data on the role of intestinal microbiota and endotoxemia in the pathogenesis of the development of arterial hypertension and the atherosclerotic process, as well as to systematize data on the effect of diet on intestinal microbiota in individuals of this category. Materials and methods: the search and selection of literary sources was carried out in systemic studies in the scientific databases cyberleninka.ru, elibrary.ru, link.springer.com, frontiersin. org, pubmed.ncbi.nlm.nih.gov, Web of Science, Google Scholar and others.

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The authors declare that there are no conflicts of interest present.